Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance

Nature Reviews Molecular Cell Biology, Год журнала: 2022, Номер 23(9), С. 623 - 640

Опубликована: Май 13, 2022

Язык: Английский

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Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

ACS Applied Bio Materials, Год журнала: 2022, Номер 5(3), С. 971 - 1012

Опубликована: Фев. 28, 2022

Traditional treatment approaches for cancer involve intravenous chemotherapy or other forms of drug delivery. These therapeutic measures suffer from several limitations such as nonspecific targeting, poor biodistribution, and buildup resistances. However, significant technological advancements have been made in terms superior modes delivery over the last few decades. Technical capability analyzing molecular mechanisms tumor biology, nanotechnology─particularly development biocompatible nanoparticles, surface modification techniques, microelectronics, material sciences─has increased. As a result, number nanostructured carriers that can deliver drugs to specific cancerous sites with high efficiency developed. This particular maneuver enables introduction substance body by controlling rate, time, place is defined system (NDDS). Because their versatility ability incorporate features water solubility, stability, biocompatibility, degradability, reverse resistance, they attracted interest scientific community, general, nanotechnologists well biomedical scientists. To keep pace rapid advancement nanotechnology, technical aspects recent NDDSs prospects need be reported coherently. address these ongoing issues, this review article provides an overview different lipids, polymers, inorganic nanoparticles. In addition, also reports challenges current points out prospective research directions nanocarriers. From our focused review, we conclude still now most advanced potent field application lipid-based, while significantly potential fields include polymer-based NDDSs. despite promises, remain practical implementations dosage caution should exercised regarding biocompatibility materials. Considering objectively, on will particularly small-to-large scale industrial researchers academicians expertise delivery, research, nanotechnology.

Язык: Английский

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Nanoparticles‐induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models

MedComm, Год журнала: 2023, Номер 4(4)

Опубликована: Июль 14, 2023

Nanoparticles (NPs) have become one of the most popular objects scientific study during past decades. However, despite wealth reports, still there is a gap, particularly in health toxicology studies, underlying mechanisms, and related evaluation models to deeply understanding NPs risk effects. In this review, we first present comprehensive landscape applications on health, especially addressing role medical diagnosis, therapy. Then, toxicity systems introduced. We describe detail effects various systems, including respiratory, nervous, endocrine, immune, reproductive carcinogenicity NPs. Furthermore, unravels mechanisms ROS accumulation, mitochondrial damage, inflammatory reaction, apoptosis, DNA cell cycle, epigenetic regulation. addition, classical such as lines mice emerging 3D organoids used for evaluating or are both Overall, review presents critical summary state NPs, giving readers more better remedy key gaps knowledge techniques.

Язык: Английский

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Green synthesis of nanoparticles from biodegradable waste extracts and their applications: a critical review

Nanotechnology for Environmental Engineering, Год журнала: 2022, Номер 8(2), С. 377 - 397

Опубликована: Авг. 24, 2022

Язык: Английский

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Cyclin E/CDK2: DNA Replication, Replication Stress and Genomic Instability

Frontiers in Cell and Developmental Biology, Год журнала: 2021, Номер 9

Опубликована: Ноя. 24, 2021

DNA replication must be precisely controlled in order to maintain genome stability. Transition through cell cycle phases is regulated by a family of Cyclin-Dependent Kinases (CDKs) association with respective cyclin regulatory subunits. In normal cycles, E-type cyclins (Cyclin E1 and Cyclin E2, CCNE1 CCNE2 genes) associate CDK2 promote G1/S transition. E/CDK2 complex mostly controls progression phosphorylation specific substrates. Oncogenic activation impairs replication, causing stress damage. As consequence, E/CDK2-induced leads genomic instability contributes human carcinogenesis. this review, we focus on the main functions molecular mechanisms which oncogenic causes cancer.

Язык: Английский

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Deubiquitinases in cancer

Nature reviews. Cancer, Год журнала: 2023, Номер 23(12), С. 842 - 862

Опубликована: Ноя. 7, 2023

Язык: Английский

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Targeting oncogene and non-oncogene addiction to inflame the tumour microenvironment

Nature Reviews Drug Discovery, Год журнала: 2022, Номер 21(6), С. 440 - 462

Опубликована: Март 15, 2022

Язык: Английский

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Targeting cyclin-dependent kinase 1 (CDK1) in cancer: molecular docking and dynamic simulations of potential CDK1 inhibitors

Medical Oncology, Год журнала: 2022, Номер 39(9)

Опубликована: Июнь 20, 2022

Язык: Английский

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The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future?

Life, Год журнала: 2023, Номер 13(2), С. 466 - 466

Опубликована: Фев. 7, 2023

Cancer is a fatal disease with complex pathophysiology. Lack of specificity and cytotoxicity, as well the multidrug resistance traditional cancer chemotherapy, are most common limitations that often cause treatment failure. Thus, in recent years, significant efforts have concentrated on development modernistic field called nano-oncology, which provides possibility using nanoparticles (NPs) aim to detect, target, treat diseases. In comparison conventional anticancer strategies, NPs provide targeted approach, preventing undesirable side effects. What more, nanoparticle-based drug delivery systems shown good pharmacokinetics precise targeting, reduced resistance. It has been documented that, cells, promote reactive oxygen species (ROS) production, induce cell cycle arrest apoptosis, activate ER (endoplasmic reticulum) stress, modulate various signaling pathways, etc. Furthermore, their ability inhibit tumor growth vivo also documented. this paper, we reviewed role silver (AgNPs) nanomedicine, discussing numerous mechanisms by they render properties under both vitro conditions, potential diagnosis cancer.

Язык: Английский

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DNA Damage Response in Cancer Therapy and Resistance: Challenges and Opportunities

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(23), С. 14672 - 14672

Опубликована: Ноя. 24, 2022

Resistance to chemo- and radiotherapy is a common event among cancer patients reason why new therapies therapeutic strategies need be in continuous investigation development. DNA damage response (DDR) comprises several pathways that eliminate maintain genomic stability integrity, but different types of cancers are associated with DDR machinery defects. Many improvements have been made recent years, providing drugs for patients, including those targeting the pathways. Currently, poly (ADP-ribose) polymerase inhibitors (PARP inhibitors) (DDRi) approved cancers, breast, ovarian, pancreatic, prostate cancer. However, PARPi resistance growing issue clinical settings increases disease relapse aggravate patients’ prognosis. Additionally, other DDRi also being found investigated. The mechanisms include reversion mutations, epigenetic modification, stabilization replication fork, increased drug efflux. This review highlights therapy, its role conventional treatments, exploitation anticancer treatment. Biomarkers treatment response, combination agents, mechanisms, liabilities discussed.

Язык: Английский

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