Pogo transposons provide tools to restrict cancer growth

Molecular Oncology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Transposable elements provide material for novel gene formation. In particular, DNA transposons have contributed several essential genes involved in various physiological or pathological conditions. Here, we discuss recent findings by Tu et al. Molecular Cell that identify Pogo transposon‐derived POGK as tumor suppressor triple‐negative breast cancer (TNBC) regulating ribosome biogenesis and restricting cell growth. An isoform‐switch TNBC results the loss of capacity to recruit epigenetic corepressor TRIM28 exert its repressive functions. These shed light on potential TE‐derived providing new therapeutic opportunities highly malignant TNBC.

Язык: Английский

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Ribosome-directed cancer therapies: the tip of the iceberg?

Trends in Pharmacological Sciences, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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POGK is a domesticated KRAB domain-containing transposable element with tumor suppressive functions in breast cancer

Trends in Cell Biology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский

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