Pogo transposons provide tools to restrict cancer growth

Molecular Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Transposable elements provide material for novel gene formation. In particular, DNA transposons have contributed several essential genes involved in various physiological or pathological conditions. Here, we discuss recent findings by Tu et al. Molecular Cell that identify Pogo transposon‐derived POGK as tumor suppressor triple‐negative breast cancer (TNBC) regulating ribosome biogenesis and restricting cell growth. An isoform‐switch TNBC results the loss of capacity to recruit epigenetic corepressor TRIM28 exert its repressive functions. These shed light on potential TE‐derived providing new therapeutic opportunities highly malignant TNBC.

Language: Английский

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Ribosome-directed cancer therapies: the tip of the iceberg?

Trends in Pharmacological Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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POGK is a domesticated KRAB domain-containing transposable element with tumor suppressive functions in breast cancer

Trends in Cell Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

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