Baicalin and baicalein in modulating tumor microenvironment for cancer treatment: A comprehensive review with future perspectives

Pharmacological Research, Год журнала: 2023, Номер 199, С. 107032 - 107032

Опубликована: Дек. 5, 2023

Cancer is a leading cause of death worldwide. The burden cancer incidence and mortality increasing rapidly. New approaches to prevention treatment are urgently needed. Natural products reliable powerful sources for anticancer drug discovery. Baicalin baicalein, two major flavones isolated from Scutellaria baicalensis Georgi, multi-purpose traditional medicinal plant in China, exhibit activities against multiple cancers. Of note, these phytochemicals extremely low toxicity normal cells. Besides their cytotoxic cytostatic toward diverse tumor cells, recent studies demonstrated that baicalin baicalein modulate variety stromal cells extracellular matrix (ECM) the microenvironment (TME), which essential tumorigenesis, progression metastasis. In this review, we summarize therapeutic potential mechanism action regulation microenvironmental immune endothelial fibroblasts, ECM reshape TME signaling, inhibition angiogenesis, progression, addition, discuss biotransformation pathways related challenges future research directions improve bioavailability clinical applications. Recent advances warrant continued study as important natural ways interception therapy.

Язык: Английский

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The Role of Diet and Nutrition in Allergic Diseases

Nutrients, Год журнала: 2023, Номер 15(17), С. 3683 - 3683

Опубликована: Авг. 22, 2023

Allergic diseases are a set of chronic inflammatory disorders lung, skin, and nose epithelium characterized by aberrant IgE Th2 cytokine-mediated immune responses to exposed allergens. The prevalence allergic diseases, including asthma, rhinitis, atopic dermatitis, has increased dramatically worldwide in the past several decades. Evidence suggests that diet nutrition play key role development severity diseases. Dietary components can differentially regulate inflammation pathways through host gut microbiota-derived metabolites, therefore influencing allergy outcomes positive or negative ways. A broad range nutrients dietary (vitamins A, D, E, minerals Zn, Iron, Se, fiber, fatty acids, phytochemicals) found be effective prevention treatment suppression type 2 inflammation. This paper aims review recent advances etiology allergies, nutritional regulation inflammation, clinical findings about nutrient supplementation treating current literature potential efficacy plant-based diets reducing symptoms. Further trials warranted examine beneficial effects anti-allergic management

Язык: Английский

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Dietary Polyphenols, Plant Metabolites, and Allergic Disorders: A Comprehensive Review

Pharmaceuticals, Год журнала: 2024, Номер 17(6), С. 670 - 670

Опубликована: Май 22, 2024

Given the ongoing rise in occurrence of allergic disorders, alterations dietary patterns have been proposed as a possible factor contributing to emergence and progression these conditions. Currently, there is significant focus on development therapies that utilize natural compounds possessing anti-allergy properties. Dietary polyphenols plant metabolites intensively researched due their well-documented anti-inflammatory, antioxidant, immunomodulatory characteristics, making them one most prominent bioactive chemicals. This study seeks discuss in-depth mechanisms by which molecules may exert anti-allergic effects, namely through capacity diminish allergenicity proteins, modulate immune responses, modify composition gut microbiota. However, further investigation required fully understand effects. paper examines existing evidence from experimental clinical studies supports idea different polyphenols, such catechins, resveratrol, curcumin, quercetin, others, can reduce inflammation, relieve symptoms food allergy, asthma, atopic dermatitis, rhinitis, prevent response. In summary, possess properties be utilized for developing both preventative therapeutic strategies targeting The also discusses constraints investigating broad usage well potential avenues future research.

Язык: Английский

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Dietary Polyphenols—Natural Bioactive Compounds with Potential for Preventing and Treating Some Allergic Conditions

Nutrients, Год журнала: 2023, Номер 15(22), С. 4823 - 4823

Опубликована: Ноя. 17, 2023

In light of the constantly increasing prevalence allergic diseases, changes in dietary patterns have been suggested as a plausible environmental explanation for development and progression these diseases. Nowadays, much attention has paid to interventions using natural substances with anti-allergy activities. this respect, polyphenols studied extensively one most prominent bioactive compounds well-documented anti-inflammatory, antioxidant, immunomodulatory properties. This review aims discuss mechanisms underlying potential anti-allergic actions related their ability reduce protein allergenicity, regulate immune response, gut microbiome modification; however, issues need be elucidated detail. paper reviews current evidence from experimental clinical studies confirming that various such quercetin, curcumin, resveratrol, catechins, many others could attenuate inflammation, alleviate symptoms food allergy, asthma, rhinitis, prevent response. Conclusively, are endowed great therefore used either preventive approaches or therapeutic relation Limitations studying widespread use well future research directions also discussed.

Язык: Английский

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Exploring plant polyphenols as anti-allergic functional products to manage the growing incidence of food allergy

Frontiers in Nutrition, Год журнала: 2023, Номер 10

Опубликована: Июнь 9, 2023

The active substances derived from plants have received increasing attention owing to their wide range of pharmacological applications, including anti-tumor, anti-allergic, anti-viral, and anti-oxidative activities. allergy epidemic is a growing global public health problem that threatens human safety. Polyphenols significant anti-allergic effects are an important source drug research development. Here, we describe recent advances in the efficacy plant polyphenols, comprehensive on cellular or animal models. current issues directions for future development this field discussed provide theoretical basis utilization these as products.

Язык: Английский

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Phytochemicals targeting lncRNAs: A novel direction for neuroprotection in neurological disorders

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 162, С. 114692 - 114692

Опубликована: Апрель 12, 2023

Язык: Английский

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Exploring Advances in Natural Plant Molecules for Allergic Rhinitis Immunomodulation in Vivo and in Vitro

International Journal of General Medicine, Год журнала: 2025, Номер Volume 18, С. 529 - 565

Опубликована: Фев. 1, 2025

Abstract: Allergic rhinitis (AR) is a prevalent allergic disease that imposes significant economic burdens and life pressures on individuals, families, society, particularly in the context of accelerating globalization increasing pathogenic factors. Current clinical therapies for AR include antihistamines, glucocorticoids administered via various routes, leukotriene receptor antagonists, immunotherapy, several decongestants. These treatments have demonstrated efficacy alleviating symptoms pathological states. However, with growing awareness rising expectations improvements quality life, these become associated higher incidence side effects an elevated risk drug resistance. Furthermore, development intricately dysregulation immune system, yet underlying pathogenetic mechanisms remain incompletely understood. In contrast, widely available natural plant molecules offer multiple targeting pathways uniquely modify typical pathophysiology through immunomodulatory processes. This review presents comprehensive analysis both vivo vitro studies modulate immunity treating AR. Additionally, we examine their specific action animal models to provide new insights developing safe effective targeted while guiding experimental applications against Keywords: molecules, rhinitis, immunomodulation, therapeutic mechanism, research progress

Язык: Английский

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Interaction between nasal epithelial cells and Tregs in allergic rhinitis responses to allergen via CCL1/CCR8

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 20, 2025

The airway epithelial barrier is the first defence against aeroallergens. Nasal cells (NECs) are vital in regulating innate and adaptive mucosal immunity allergic rhinitis (AR). Tregs produce cytokines essential for immunomodulatory activities allergen immunotherapy. Understanding relationship between NECs hyperresponsiveness network developing novel treatments. Using an vitro human Treg-NEC co-culture system of AR health control group, chemokine expression profiles were examined using immunohistochemistry, RT-PCR, ELISA, functional surface markers detected flow cytometric analysis. Correlation analysis was performed derived from CD4+CD8+Foxp3+ group after co-culture, including TSLP/CTLA4, CCL1/CTLA4, TSLP/CCR8, CCL1/CCR8. CCR8 CTLA-4 expressions co-culturing higher than single culture. Following Derp1 stimulation, TSLP, IL-25 TGF-β + increased. CCL1 mRNA lower group. In TSLP higher, protein levels decreased. There no significant differences IL-25, IL-10. When Treg added, changes similar to that observed pNECs. After CCL1/CCR8 positively correlated AR. Human pNECs can communicate with directly, may be pathway play a key role immune

Язык: Английский

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Exploring the anti-anaphylaxis potential of natural products: A Review

Inflammopharmacology, Год журнала: 2025, Номер unknown

Опубликована: Март 19, 2025

Abstract Allergies are a common health issue affecting many people around the world, especially in developed countries. They occur when immune system overreacts to substances that usually harmless. Some allergic conditions include asthma, sinus infections, skin rashes, food allergies, hay fever, severe reactions, eczema, swelling, and reactions medications or insect stings. The causes of these allergies complex often linked genetics, which can lead heightened responses known as atopy. Throughout history, plant extracts have been used for various purposes, including medicine food. In addition, their bioactive compounds show wide range beneficial effects, such reducing fighting oxidative stress, mast cell stabilizers, lowering inflammation, highlighting potential treating conditions. Flavonoids phenolic commonly anaphylaxis potent anti-inflammatory action. This review aims promote use natural products treatments anaphylaxis. discovery new drugs derived from sources holds significant promise management

Язык: Английский

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Baicalin: an active natural product with potential medicinal values

Journal of Asian Natural Products Research, Год журнала: 2025, Номер unknown, С. 1 - 25

Опубликована: Апрель 3, 2025

Baicalin, a flavonoid derived from the dicotyledonous plant Scutellaria baicalensis Georgi (SBG), is applied to treat various -disorders due its pharmacological effects such as anti-inflammatory, antiviral, antibacterial, liver-protecting, lipid-lowering, and neuroprotection. However, baicalin's limited solubility hampers absorption. This article reviews properties, including pharmacokinetics, cytotoxicity, drug interactions, therapeutic potential, especially for cardiovascular diseases, obesity, liver-lipid disorders, aiming promote development in medicine, dairy livestock feed, nutritional health products cosmetics humans other fields.

Язык: Английский

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