International Journal of Drug Delivery Technology,
Год журнала:
2024,
Номер
14(02), С. 925 - 931
Опубликована: Июнь 24, 2024
This
study
aimed
to
examine
the
influence
of
β
cyclodextrin
(βCD)
and
γ
(γCD)
alone
in
combination
with
L-lysine
on
ellagic
acid
(EA)
solubility.
Indeed,
complexation
cyclodextrins
can
be
used
improving
solubility
drugs
poorly
soluble
water
such
as
EA.
EA
is
a
Biopharamceutical
Classification
System
(BCS)
IV
bioactive
polyphenol
numerous
therapeutic
activities,
including
antimalarial
activities.
However,
its
unfavorable
physicochemical
properties
limit
use.
Therefore,
after
phase
study,
we
successfully
prepared
EA-βCD
CD
binary
solid
complexes
using
freeze-drying
technique.
Methods
proton
nuclear
magnetic
resonance
(1H-NMR)
analysis
fourier-transform
infrared
(FTIR)
spectroscopy
were
characterize
inclusion
behaviors
both
solution
forms.
The
results
indicated
Ap-type
diagrams
two
(CDs).
was
multiplied
by
9.92
2.98
presence
γCD
βCD
respectively.
Moreover,
characterization
FTIR
revealed
involvement
C=O
OH
groups
interaction
CDs.
NMR
spectroscopic
that
formation
partial.
these
did
not
indicate
appearance
γCD.
These
relatively
modest
terms
increased
solubility,
obtained
cyclodextrins,
prompted
us
use
third
compound,
l-lysine,
enhance
CDs
complexation.
Thus,
ternary
led
very
significant
increase
incorporation
into
EA-L-lysine-βCD
at
pH
7.4
factor
555
663,
Pharmaceutics,
Год журнала:
2022,
Номер
14(4), С. 703 - 703
Опубликована: Март 25, 2022
Current
cannabidiol
(CBD)
formulations
are
challenged
with
unpredictable
release
and
absorption.
Rational
design
of
a
rectal
colloid
delivery
system
can
provide
practical
alternative.
In
this
study
the
inherent
physiochemical
properties
transferosomes
were
harnessed
for
development
nano-sized
transfersomes
to
yield
more
stable
release,
absorption,
bioavailability
CBD
as
colloid.
Transfersomes
composed
soya
lecithin,
cholesterol,
polysorbate
80
synthesized
via
thin
film
evaporation
characterized
size,
entrapment
efficiency
(%),
morphology,
ex
vivo
permeation,
physicochemical
stability.
The
optimized
formulation
entrapped
up
80.0
±
0.077%
hydrodynamic
particle
size
130
nm,
PDI
value
0.285,
zeta
potential
-15.97
mV.
morphological
investigation
SEM
TEM
revealed
that
spherical
unilamellar
vesicles
coinciding
enhanced
permeation
across
excised
rat
colorectal
membrane.
Furthermore,
improved
stability
encapsulated
6
months
at
room
temperature
showed
significant
promise
promoted
tissue
superior
afforded
tunable
kinetics
botanical
therapeutic
poor
bioavailability.
Pharmaceutical Research,
Год журнала:
2023,
Номер
40(5), С. 1087 - 1114
Опубликована: Янв. 12, 2023
Abstract
The
use
of
cannabidiol
(CBD)
for
treating
brain
disorders
has
gained
increasing
interest.
While
the
mechanism
action
CBD
in
these
conditions
is
still
under
investigation,
been
shown
to
affect
numerous
different
drug
targets
that
are
involved
disorders.
Here
we
review
preclinical
and
clinical
evidence
on
potential
therapeutic
various
Moreover,
also
examine
delivery
approaches
have
applied
CBD.
Due
slow
absorption
low
bioavailability
with
current
oral
therapy,
more
efficient
routes
administration
bypass
hepatic
metabolism,
particularly
pulmonary
delivery,
should
be
considered.
Comparison
pharmacokinetic
studies
highlight
advantages
intranasal
inhalation
over
other
(oral,
injection,
sublingual,
buccal,
transdermal)
These
two
being
non-invasive
able
achieve
fast
increase
bioavailability,
attracting
interest
applications,
research
development
expected
near
future.
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 355 - 355
Опубликована: Март 10, 2025
Cyclodextrin
(CD)-based
drug
delivery
systems
have
emerged
as
a
promising
strategy
to
overcome
limitations
commonly
encountered
in
antidepressant
therapy,
including
low
bioavailability,
poor
solubility,
and
suboptimal
penetration
of
the
blood–brain
barrier.
This
review
synthesizes
current
evidence
demonstrating
that
complexing
various
classes
antidepressants—such
tricyclic
antidepressants
(TCAs),
selective
serotonin
reuptake
inhibitors
(SSRIs),
atypical
antidepressants—with
β-CD
or
its
derivatives
significantly
enhances
solubility
stability.
In
addition,
encapsulation
with
CDs
can
diminish
systemic
toxicity
improve
pharmacokinetics,
thereby
helping
optimize
dosage
regimens
reduce
adverse
effects.
Analysis
published
vitro
vivo
studies
indicates
CD
formulations
not
only
boost
therapeutic
efficacy
but
also
enable
sustained
targeted
release,
which
is
critical
for
drugs
requiring
precise
plasma
tissue
concentrations.
When
compared
other
carriers
(e.g.,
liposomes,
polymeric
nanoparticles,
dendrimers),
CD-based
often
stand
out
their
ease
formulation,
biocompatibility,
cost-effectiveness,
although
limited
drug-loading
capacity
be
drawback.
We
recommend
expanding
trials
substantiate
clinical
benefits
CD–antidepressant
complexes,
particularly
treatment-resistant
cases
specific
subpopulations
elderly
pediatric
patients).
Additional
investigations
should
explore
hybrid
systems—combining
advanced
nano-
macroparticles—to
amplify
advantages
address
any
limitations.
Ultimately,
integrating
into
holds
substantial
potential
refine
therapy
outcomes,
events,
pave
way
more
personalized,
effective
interventions
depression.
Foods,
Год журнала:
2022,
Номер
11(3), С. 376 - 376
Опубликована: Янв. 27, 2022
Wide
applications
of
cannabidiol
(CBD)
in
the
food
and
pharmaceutical
industries
are
limited
due
to
its
low
bioavailability,
sensitivity
environmental
pressures
water
solubility.
Zein
nanoparticles
were
stabilized
by
whey
protein
(WP)
for
delivery
using
a
modified
anti-solvent
approach.
Particle
size,
surface
charge,
encapsulation
efficiency,
re-dispersibility
influenced
zein
WP
ratio.
Under
optimized
conditions
at
1:4,
zein-WP
fabricated
with
CBD
(200
μg/mL)
further
characterized.
absorbed
on
via
hydrogen
bond,
hydrophobic
forces,
electrostatic
attraction.
The
showed
excellent
storage
stability
(4
°C,
dark)
effectively
protected
degradation
against
heat
UV
light.
In
vivo
pharmacokinetic
study
demonstrated
that
displayed
2-times
1.75-fold
enhancement
maximum
concentration
(C
max)
area
under
curve
(AUC)
as
compared
free-form
CBD.
data
indicated
feasibility
developing
based
encapsulation,
protection,
International Journal of Pharmaceutics,
Год журнала:
2024,
Номер
659, С. 124267 - 124267
Опубликована: Май 24, 2024
In
this
study,
Cannabidiol
crystals
(CBD)
were
used
as
a
BCS
class
II
model
drug
to
generate
novel
therapeutic
deep
eutectic
solvent
(THEDES)
with
easy
preparation
using
caprylic
acid
(CA).
The
hydrogen
bonding
interaction
was
confirmed
by
different
techniques
such
FT-IR
and
NMR,
resulting
in
hydrophobic
system
suitable
for
liquid
formulations.
CBD-based
THEDES,
combined
specific
mixture
of
surfactants
co-surfactants,
successfully
formed
self-emulsifying
delivery
(SEDDS)
that
generated
uniform
nano-sized
droplets
once
dispersed
water.
Hence,
the
THEDES
showed
compatibility
approach,
offering
an
alternative
method
load
drugs
at
their
dosage.
Physical
stability
concerns
regarding
unconventional
oily
phase
addressed
through
stress
tests
multiple
dynamic
light
scattering,
demonstrating
robustness
system.
addition,
formulated
SEDDS
proved
effective
protecting
CBD
from
harsh
acidic
gastric
environment
up
2
h
pH
1.2.
Furthermore,
vitro
studies
have
safety
formulation
ability
permeate
Caco-2
cells
when
formulated.
This
investigation
highlights
potential
incorporation
lipid-based
formulations
like
SEDDS,
expanding
avenues
innovative
oral
approaches.
