Chemico-Biological Interactions,
Journal Year:
2024,
Volume and Issue:
394, P. 110988 - 110988
Published: April 3, 2024
Epilepsy
is
a
neurological
disorder
characterized
by
overstimulation
of
neurotransmitters
and
uncontrolled
seizures.
Current
medications
for
epilepsy
result
in
adverse
effects
or
insufficient
seizure
control,
highlighting
the
necessity
to
develop
alternative
therapies.
Cannabidiol
(CBD),
derived
from
cannabis
plants,
has
been
popularly
explored
as
an
alternative.
CBD
shown
have
anti-convulsivatng
muscle-relaxing
properties,
which
used
patients
with
promising
results.
research
explores
varying
dosages
either
adult
paediatric
patients,
little
no
comparison
between
two
populations.
In
this
review,
we
aim
at
consolidating
data
comparing
effect
pharmacokinetic
properties
across
these
patient
When
absorption,
there
was
show
differences
patients.
Similarly,
limited
information
available
distribution
CBD,
but
higher
volume
found
population.
From
metabolism
perspective,
population
had
greater
success
rate
when
treated
drug
compared
elimination,
were
clear
distinctions
clearance
The
drug's
half-life
highly
variable
both
populations,
paediatrics
having
lower
range
than
adults.
summary,
more
significant
reduction
severity
seizures
upon
treatment.
complexity
operates
highlights
need
further
studies
compound
understand
why
occur
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(4), P. 703 - 703
Published: March 25, 2022
Current
cannabidiol
(CBD)
formulations
are
challenged
with
unpredictable
release
and
absorption.
Rational
design
of
a
rectal
colloid
delivery
system
can
provide
practical
alternative.
In
this
study
the
inherent
physiochemical
properties
transferosomes
were
harnessed
for
development
nano-sized
transfersomes
to
yield
more
stable
release,
absorption,
bioavailability
CBD
as
colloid.
Transfersomes
composed
soya
lecithin,
cholesterol,
polysorbate
80
synthesized
via
thin
film
evaporation
characterized
size,
entrapment
efficiency
(%),
morphology,
ex
vivo
permeation,
physicochemical
stability.
The
optimized
formulation
entrapped
up
80.0
±
0.077%
hydrodynamic
particle
size
130
nm,
PDI
value
0.285,
zeta
potential
-15.97
mV.
morphological
investigation
SEM
TEM
revealed
that
spherical
unilamellar
vesicles
coinciding
enhanced
permeation
across
excised
rat
colorectal
membrane.
Furthermore,
improved
stability
encapsulated
6
months
at
room
temperature
showed
significant
promise
promoted
tissue
superior
afforded
tunable
kinetics
botanical
therapeutic
poor
bioavailability.
Foods,
Journal Year:
2022,
Volume and Issue:
11(3), P. 376 - 376
Published: Jan. 27, 2022
Wide
applications
of
cannabidiol
(CBD)
in
the
food
and
pharmaceutical
industries
are
limited
due
to
its
low
bioavailability,
sensitivity
environmental
pressures
water
solubility.
Zein
nanoparticles
were
stabilized
by
whey
protein
(WP)
for
delivery
using
a
modified
anti-solvent
approach.
Particle
size,
surface
charge,
encapsulation
efficiency,
re-dispersibility
influenced
zein
WP
ratio.
Under
optimized
conditions
at
1:4,
zein-WP
fabricated
with
CBD
(200
μg/mL)
further
characterized.
absorbed
on
via
hydrogen
bond,
hydrophobic
forces,
electrostatic
attraction.
The
showed
excellent
storage
stability
(4
°C,
dark)
effectively
protected
degradation
against
heat
UV
light.
In
vivo
pharmacokinetic
study
demonstrated
that
displayed
2-times
1.75-fold
enhancement
maximum
concentration
(C
max)
area
under
curve
(AUC)
as
compared
free-form
CBD.
data
indicated
feasibility
developing
based
encapsulation,
protection,
Pharmaceutical Research,
Journal Year:
2023,
Volume and Issue:
40(5), P. 1087 - 1114
Published: Jan. 12, 2023
Abstract
The
use
of
cannabidiol
(CBD)
for
treating
brain
disorders
has
gained
increasing
interest.
While
the
mechanism
action
CBD
in
these
conditions
is
still
under
investigation,
been
shown
to
affect
numerous
different
drug
targets
that
are
involved
disorders.
Here
we
review
preclinical
and
clinical
evidence
on
potential
therapeutic
various
Moreover,
also
examine
delivery
approaches
have
applied
CBD.
Due
slow
absorption
low
bioavailability
with
current
oral
therapy,
more
efficient
routes
administration
bypass
hepatic
metabolism,
particularly
pulmonary
delivery,
should
be
considered.
Comparison
pharmacokinetic
studies
highlight
advantages
intranasal
inhalation
over
other
(oral,
injection,
sublingual,
buccal,
transdermal)
These
two
being
non-invasive
able
achieve
fast
increase
bioavailability,
attracting
interest
applications,
research
development
expected
near
future.
International Journal of Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
659, P. 124267 - 124267
Published: May 24, 2024
In
this
study,
Cannabidiol
crystals
(CBD)
were
used
as
a
BCS
class
II
model
drug
to
generate
novel
therapeutic
deep
eutectic
solvent
(THEDES)
with
easy
preparation
using
caprylic
acid
(CA).
The
hydrogen
bonding
interaction
was
confirmed
by
different
techniques
such
FT-IR
and
NMR,
resulting
in
hydrophobic
system
suitable
for
liquid
formulations.
CBD-based
THEDES,
combined
specific
mixture
of
surfactants
co-surfactants,
successfully
formed
self-emulsifying
delivery
(SEDDS)
that
generated
uniform
nano-sized
droplets
once
dispersed
water.
Hence,
the
THEDES
showed
compatibility
approach,
offering
an
alternative
method
load
drugs
at
their
dosage.
Physical
stability
concerns
regarding
unconventional
oily
phase
addressed
through
stress
tests
multiple
dynamic
light
scattering,
demonstrating
robustness
system.
addition,
formulated
SEDDS
proved
effective
protecting
CBD
from
harsh
acidic
gastric
environment
up
2
h
pH
1.2.
Furthermore,
vitro
studies
have
safety
formulation
ability
permeate
Caco-2
cells
when
formulated.
This
investigation
highlights
potential
incorporation
lipid-based
formulations
like
SEDDS,
expanding
avenues
innovative
oral
approaches.
