Nanomaterials,
Год журнала:
2022,
Номер
12(7), С. 1151 - 1151
Опубликована: Март 30, 2022
Aspartic
acid
stabilized
iron
oxide
nanoparticles
(A-IONPs)
with
globular
shape
and
narrow
size
distribution
were
prepared
by
the
co-precipitation
method
in
aqueous
medium.
A
quantum-mechanical
approach
to
aspartic
optimized
structure
displayed
negative
charged
sites,
relatively
high
dipole
moment,
hydrophilicity,
which
recommended
it
for
interaction
cations
surrounding
water
electrical
dipoles.
A-IONPs
characterized
TEM,
XRD,
ATR-FTIR,
EDS,
DSC,
TG,
DLS,
NTA,
VSM
techniques.
Theoretical
study
carried
out
applying
Hartree-Fock
density
functional
algorithms
suggested
that
some
properties
related
can
develop
molecules.
The
results
of
experimental
investigation
showed
mean
value
particle
physical
diameters
was
9.17
±
2.2
nm
according
TEM
image
analysis,
crystallite
about
8.9
XRD
data,
while
magnetic
diameter
8.8
nm,
as
determined
from
data
interpretation
Langevin's
theory.
A-IONP
suspension
zeta-potential
-11.7
mV,
NTA
revealed
a
hydrodynamic
153.9
nm.
These
recommend
biomedical
applications.
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Июль 20, 2023
Abstract
Extracellular
vesicles
(EVs)
are
nano-sized,
natural,
cell-derived
that
contain
the
same
nucleic
acids,
proteins,
and
lipids
as
their
source
cells.
Thus,
they
can
serve
natural
carriers
for
therapeutic
agents
drugs,
have
many
advantages
over
conventional
nanocarriers,
including
low
immunogenicity,
good
biocompatibility,
blood
–
brain
barrier
penetration,
capacity
gene
delivery.
This
review
first
introduces
classification
of
EVs
then
discusses
several
currently
popular
methods
isolating
purifying
EVs,
EVs-mediated
drug
delivery,
functionalization
carriers.
Thereby,
it
provides
new
avenues
development
EVs-based
strategies
in
different
fields
medicine.
Finally,
highlights
some
challenges
future
perspectives
with
regard
to
clinical
application
EVs.
Graphical
Bioactive Materials,
Год журнала:
2024,
Номер
36, С. 126 - 156
Опубликована: Март 2, 2024
Small
extracellular
vesicles
(sEVs)
are
known
to
be
secreted
by
a
vast
majority
of
cells.
These
sEVs,
specifically
exosomes,
induce
specific
cell-to-cell
interactions
and
can
activate
signaling
pathways
in
recipient
cells
through
fusion
or
interaction.
nanovesicles
possess
several
desirable
properties,
making
them
ideal
for
regenerative
medicine
nanomedicine
applications.
properties
include
exceptional
stability,
biocompatibility,
wide
biodistribution,
minimal
immunogenicity.
However,
the
practical
utilization
particularly
clinical
settings
at
large
scale,
is
hindered
expensive
procedures
required
their
isolation,
limited
circulation
lifetime,
suboptimal
targeting
capacity.
Despite
these
challenges,
sEVs
have
demonstrated
remarkable
ability
accommodate
various
cargoes
found
extensive
applications
biomedical
sciences.
To
overcome
limitations
broaden
potential
applications,
researchers
should
strive
deepen
understanding
current
loading,
characterization
techniques.
Additionally,
acquiring
fundamental
knowledge
about
origins
employing
state-of-the-art
methodologies
expand
research
scope.
This
review
provides
comprehensive
overview
exosome-based
strategies
diverse
domains,
encompassing
cancer
therapy,
immunotherapy,
biomarker
Furthermore,
we
emphasize
immense
exosomes
medicine.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(14), С. 7794 - 7794
Опубликована: Июль 16, 2024
Exosomes,
small
membrane-bound
vesicles
secreted
by
cells,
have
gained
significant
attention
for
their
therapeutic
potential.
Measuring
30–100
nm
in
diameter
and
derived
from
various
cell
types,
exosomes
play
a
crucial
role
intercellular
communication
transferring
proteins,
lipids,
RNA
between
cells.
This
review
analyzes
existing
literature
on
the
clinical
applications
of
exosomes.
We
conducted
comprehensive
search
peer-reviewed
articles
trial
data
to
evaluate
benefits,
limitations,
challenges
exosome-based
therapies.
Key
areas
focus
included
regenerative
medicine,
cancer
therapy,
gene
diagnostic
biomarkers.
highlights
vast
In
facilitate
tissue
repair
regeneration.
can
deliver
agents
directly
tumor
serve
as
vectors
delivery.
As
biomarkers,
they
are
useful
diagnosing
diseases.
Challenges
such
isolation,
purification,
characterization
were
identified.
Current
trials
demonstrate
potential
therapies,
though
also
reveal
hurdles.
Regulatory
issues,
including
need
standardization
validation
exosome
products,
critical
advancing
these
While
progress
has
been
made
understanding
biology,
further
research
is
essential
fully
unlock
Addressing
regulatory
successful
application
practice.
provides
concise
overview
exosomes,
emphasizing
both
promise
obstacles
that
be
overcome.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Авг. 2, 2024
Abstract
Neurodegenerative
disorders
are
complex,
progressive,
and
life-threatening.
They
cause
mortality
disability
for
millions
of
people
worldwide.
Appropriate
treatment
neurodegenerative
diseases
(NDs)
is
still
clinically
lacking
due
to
the
presence
blood-brain
barrier
(BBB).
Developing
an
effective
transport
system
that
can
cross
BBB
enhance
therapeutic
effect
neuroprotective
agents
has
been
a
major
challenge
NDs.
Exosomes
endogenous
nano-sized
vesicles
naturally
carry
biomolecular
cargoes.
Many
studies
have
indicated
exosome
content,
particularly
microRNAs
(miRNAs),
possess
biological
activities
by
targeting
several
signaling
pathways
involved
in
apoptosis,
inflammation,
autophagy,
oxidative
stress.
Exosome
content
influence
cellular
function
healthy
or
pathological
ways.
Furthermore,
since
exosomes
reflect
features
parental
cells,
their
cargoes
offer
opportunities
early
diagnosis
intervention
diseases.
unique
characteristics
make
them
ideal
delivering
drugs
directly
brain.
These
include
ability
pass
through
BBB,
biocompatibility,
stability,
innate
properties.
This
review
emphasizes
role
alleviating
NDs
discusses
associated
molecular
mechanisms.
exosomes,
making
promising
natural
transporter
various
medications
brain
combat
NDs,
also
discussed.
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
148, С. 112752 - 112752
Опубликована: Фев. 24, 2022
Exosomes
are
nano-sized
structures
that
found
in
semen,
epididymal
–fluid,
endometrium,
as
well
follicular
fluid.
They
responsible
for
transporting
bioactive
cargo-
proteins,
lipids,
and
nucleic
acids.
have
been
proven
to
influence
processes
both
female
male
reproductive
systems,
including
gametogenesis,
acrosomal
reaction,
sperm
capacitation,
embryo
implantation
the
endometrium.
made
of
same
particles
cells
they
come
from
secreted
by
normal
pathological
cells.
Therefore,
exosomes
can
reflect
physiological
state
Moreover,
due
transportation
biomolecules,
participate
intercellular
communication
be
used
biomarkers
many
diseases,
ovarian,
endometrial
prostate
cancer.
Identification
could
contribute
a
better
understanding
genital
dysfunction
fertility
disorders.
Pharmaceutical Development and Technology,
Год журнала:
2023,
Номер
28(5), С. 383 - 402
Опубликована: Апрель 22, 2023
AbstractExosomes
are
one
type
of
extracellular
vesicles
with
size
ranging
from
30
to
150
nm,
which
involved
in
intercellular
communication
by
transporting
specific
proteins,
nucleic
acids,
and
low
molecular
weight
metabolites.
The
competence
exosomes
transfer
biological
materials
recipient
cells
have
made
them
suitable
for
biomedical
use.
Therefore,
been
studied
as
drug
delivery
systems
various
diseases
due
immunogenicity,
preferred
tumor
homing,
innate
acquired
targetability,
stability.
They
secreted
almost
all
multivesicular
endosomes
retrieved
body
fluids
including
bile,
saliva,
blood,
lymph,
urine,
cerebrospinal
fluid,
milk,
etc.
Plants’
organs
also
secrete
(Plant-derived
exosome-like
nanoparticles
(PELNs))
considered
an
economical
affordable
source
production.
PELNs
pharmacologically
rich
active
molecules
because
owning
unique
compositional
morphological
features
they
can
be
used
natural
nano-carrier
exogenous
molecules.
In
this
review,
the
bio-component
applications
neural
disorders,
tumor-targeted
delivery,
gene
reviewed
different
plants
such
aloe,
turmeric,
ginger,
lemon,
grapefruit,
grape,
strawberry.Keywords:
Biomedical
applicationexosomesplant-derived
nanoparticlesdrug
AcknowledgmentsThis
article
is
result
a
research
project
approved
Student
Research
Committee
Kerman
University
Medical
Sciences
No.
402000042,
was
carried
out
financial
support
Vice
Chancellor
Technology
UniversityDisclosure
statementNo
potential
conflict
interest
reported
author(s).Additional
informationFundingThe
author(s)
there
no
funding
associated
work
featured
article.
