Applied Organometallic Chemistry,
Год журнала:
2024,
Номер
38(11)
Опубликована: Авг. 5, 2024
Treatment
of
two
classes
oxazolinyl‐indolate
ligand
precursors
with
an
equivalent
trimethylaluminum
reagent
afforded
four
corresponding
aluminum
dimethyl
complexes.
Intramolecular
functional
groups
were
employed
to
switch
coordination
behaviors,
resulting
in
the
formation
five‐
or
six‐membered
metallocyclic
The
screening
prepared
complexes,
mediated
by
9‐anthracenemethanol
as
initiating
ring‐opening
polymerization
ε‐caprolactone,
showed
significant
activities
at
room
temperature.
compound
ligated
2‐(1
H
‐indol‐2‐yl)‐4,4‐dimethyl‐4,5‐dihydrooxazole
possessed
a
suitable
chelated
ring
size,
and
its
intrinsic
electronic
properties
maintained
higher
activity.
Applied Organometallic Chemistry,
Год журнала:
2025,
Номер
39(3)
Опубликована: Фев. 18, 2025
ABSTRACT
A
new
complex
of
type
[Nd
(HL)
(NO
3
)
2
]
has
been
synthesized
with
a
Schiff
base
ligand
H
L
derived
from
2‐hydroxy‐3‐methoxybenzaldehyde
and
L‐histidine.
The
structure
the
was
established
using
elemental
analysis,
molar
conductivities,
FT‐IR,
1
HNMR,
SEM,
x‐ray
diffraction
(XRD)
spectroscopy.
FT‐IR
data
revealed
that
acts
as
tetradentate
through
carboxylic
acid,
azomethine
nitrogen,
methoxy
oxygen,
hydroxyl
groups.
Based
on
electronic
spectra,
an
octahedral
configuration
hypothesized
for
complex.
TGA
method
employed
to
study
thermal
behavior
its
complex,
thermodynamic
parameters
were
determined
Coats–Redfern
equations.
XRD
analysis
compounds
possess
nanoscale
dimensions,
their
crystallinity
significantly
enhanced
by
coordination
Nd(III)
ion
L.
DFT
calculations
performed
optimize
geometry
proposed
structures,
indicating
improved
stabilities.
reduced
HOMO–LUMO
gap
in
further
highlights
remarkable
conductive
properties.
surface
morphology
analyzed
SEM
investigate
structural
characteristics.
images
reveal
variety
particle
shapes,
including
elongated,
prismatic,
irregular
blocky
particles
sharp
edges,
suggesting
crystalline
nature.
evaluated
anticancer
activity
against
prostate
carcinoma,
breast
lung
carcinoma
cell
lines.
inhibition
rate
92.81%,
93.25%,
94.58%,
respectively.
results
demonstrated
exhibited
compared
alone,
likely
due
These
findings
suggest
holds
promise
potent
agent.
RSC Advances,
Год журнала:
2024,
Номер
14(2), С. 995 - 1008
Опубликована: Янв. 1, 2024
In
the
present
study,
spiro
compounds
are
shown
to
have
distinctive
characteristics
because
of
their
interesting
conformations
and
structural
impacts
on
biological
systems.
Applied Organometallic Chemistry,
Год журнала:
2024,
Номер
38(11)
Опубликована: Июль 29, 2024
Five
novel
complexes
of
nickel
(II)(
1
),
zinc
2
zirconium
(IV)(
3
lanthanum
(III)(
4
thorium
5
with
the
dithranol
(
Dithr
)
ligand
and
glycine
Gly
were
synthesized
characterized.
Their
structures
investigated
using
elemental
analysis,
molar
conductance
(Λ),
magnetic
studies
μ
eff
spectroscopic
methods
(FT‐IR,
UV–Vis.,
H
NMR,
XRD),
mass
spectrometry,
TG/DTG
DTA.
Findings
revealed
that
was
chelated
via
two
hydroxyl
oxygen
atoms
carbonyl
group
while,
through
carboxylic
nitrogen
atom.
All
appeared
ratio
1:1:1
M
:
electrolytes
1:1
for
complexes,
1:2
complex,
1:3
complex
according
to
analysis
conductivity
data.
metal‐chelates,
except
Th
(IV)‐complex,
confirmed
have
lattice
water
molecules
based
on
their
thermal
behavior.
Average
crystalline
size
all
compounds
calculated
XRD
found
in
range
35.50–55.57
nm,
indicating
existed
as
nanocrystalline
structure,
(IV)
complex.
Then,
we
studied
cytotoxic
effects
our
synthetic
drugs
survival
an
aggressive‐breast‐cancer‐histotype“66cl‐4.”
Given
its
involvement
cancer‐metastasis,
matrix‐metalloproteinase‐(MMP)‐9
protein
expression
evaluated
western‐blotting‐assays.
Th(IV)‐complex
emerged
most
effective
option
inhibiting
cancer‐cells‐proliferation
(IC
50
9.39
μM),
suppressed
MMP‐9
levels
by
86%,
at
25
μM
dose,
drug‐binding‐affinity
interpreted
molecular
modeling.
Applied Organometallic Chemistry,
Год журнала:
2024,
Номер
38(6)
Опубликована: Апрель 18, 2024
In
this
paper,
we
have
examined
eight
new
first‐row
transition
metal
complexes
(
1
–
8
).
Mutli‐donor
ligands
based
on
barbituric
and
thiobarbituric
acids
were
used
in
complexation
reactions.
The
synthesized
analyzed
using
FT‐IR
UV–vis
spectroscopy,
elemental
(CHN)
analysis,
single‐crystal
X‐ray
diffraction
analysis.
These
exhibited
significant
urease
enzyme
inhibition
with
IC
50
values
the
range
of
13.73
±
1.08–43.21
1.50
μM.
We
observed
excellent
binding
orientation
these
active
site
Urease.
molecular
docking
results
correlate
well
vitro
observations.
Applied Organometallic Chemistry,
Год журнала:
2025,
Номер
39(4)
Опубликована: Март 4, 2025
ABSTRACT
The
condensation
of
3‐amino‐1H‐1,2,4‐triazole
with
2‐benzoyl
benzoic
acid
produced
a
novel
Schiff
base
ligand
(H
2
L).
structure
synthesized
H
L
and
its
metal
complexes
[Co(II),
Ni(II),
Cu(II),
Zr(IV)]
were
characterized
by
mass
spectrometry,
FT‐IR,
1
NMR,
XRD,
UV‐vis,
ESR,
TG‐DTG
analyses
also,
supported
computational
approaches.
FT‐IR
spectral
data
showed
that
acts
in
tridentate
mode
through
azomethine
nitrogen,
the
nitrogen
triazole,
carboxylate
group
oxygen.
XRD
results
indicated
compounds
polycrystalline
monoclinic
systems
for
L,
Co(II),
Cu(II)
but
orthorhombic
Zr(IV)
Ni(II)
complexes.
Coats–Redfern
Horowitz–Metzger
equations
utilized.
optical
characteristics
evaluated.
From
DFT,
Δ
E
values
our
varied
from
0.033
eV
more
reactive
Co(II)
complex
to
0.109
less
Zr(IV)complex
compared
(0.113
eV).
Also,
σ
values,
considered
soft
L.
band
gap
(
g
)
those
DFT
found
be
equivalent.
metallic
assessed
their
antibacterial
activity
as
well
antifungal
activity.
exhibited
significant
antimicrobial
efficacy.
evaluated
cytotoxic
against
ATB‐37
colon
cancer
cell
line.
Notably,
effects
than
other
compounds.
subjected
molecular
docking
into
TRK
(PDB:
1t46),
DHFR
2W9H),
PaaABC
4IIT),
NatB
5K04)
predict
or
help
interpretation
cytotoxicity
potential.
electrochemical
behavior
complex–modified
electrodes
was
cyclic
voltammetry
(CV),
galvanostatic
charge–discharge
(GCD),
impedance
spectroscopy
(EIS)
measurements,
all
performed
6‐M
KOH
electrolyte.
have
much
higher
capacitance
modified
electrodes.
