Mitochondrion, Год журнала: 2024, Номер 76, С. 101873 - 101873
Опубликована: Март 17, 2024
Язык: Английский
Materials Today Chemistry, Год журнала: 2024, Номер 35, С. 101894 - 101894
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
34
European Polymer Journal, Год журнала: 2024, Номер 206, С. 112800 - 112800
Опубликована: Янв. 26, 2024
Язык: Английский
Процитировано
24
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Июль 19, 2024
Abstract Colorectal cancer, the third most prevalent cancer globally, contributes significantly to mortality rates, with over 1.9 million reported cases and nearly 935,000 fatalities annually. Surgical resection is a primary approach for localized colorectal tumors, adjunct therapies like chemotherapy, radiotherapy, targeted/immunotherapy considered depending on tumor stage. However, despite preferences targeted immunotherapy post-surgery, chemotherapy remains commonly chosen due its lower cost high cancer-killing efficiency. Yet, faces issues such as resistance severe side effects. Nanotechnology has emerged in therapy by alleviating drawbacks of current treatment approaches. In past few decades, inorganic nanoparticles have shown promise combating offering advantages conventional chemotherapy. Compared organic nanoparticles, exhibit properties photosensitivity, conductivity, magnetic allure, thermal proficiency, allowing them function both drug carriers therapeutic agents. Derived primarily from carbon, silica, metals, metal oxides, they offer superior drug-loading capacity, heightened quantum yield, participation advanced photothermal photodynamic therapies. This review provides brief overview pathophysiology pivotal role therapy, delivery. Additionally, it discusses numerous based recent literature. Graphical abstract
Язык: Английский
Процитировано
24
Biologics, Год журнала: 2024, Номер Volume 18, С. 229 - 255
Опубликована: Сен. 1, 2024
Natural products have proven to be promising anti-cancer agents due their diverse chemical structures and bioactivity.This review examines central role in cancer treatment, focusing on mechanisms of action therapeutic benefits.Medicinal plants contain bioactive compounds, such as flavonoids, alkaloids, terpenoids polyphenols, which exhibit various anticancer properties.These compounds induce apoptosis, inhibit cell proliferation cycle progression, interfere with microtubule formation, act topoisomerase targets, angiogenesis, modulate key signaling pathways, improve the tumor microenvironment, reverse drug resistance activate immune cells.Herbal drugs offer advantages, particularly selective toxicity against cells, reducing adverse side effects associated conventional chemotherapy.Recent studies clinical trials highlight benefits herbal medicines alleviating effects, improving tolerance chemotherapy occurrence synergistic treatments.For example, medicine SH003 was found safe potentially effective treatment solid cancers, while Fucoidan showed anti-inflammatory properties that are beneficial for patients advanced cancer.The current research landscape is extensive.Numerous investigating efficacy, safety cancers lung, prostate, breast hepatocellular carcinoma.Promising developments include polypharmacological approach, combination therapies, immunomodulation improvement quality life.However, there still challenges development use natural drugs, need further into action, possible interactions optimal dosage.Standardizing extracts, bioavailability delivery, overcoming regulatory acceptance hurdles critical issues addressed.Nonetheless, warrant investigation development.Multidisciplinary collaboration essential advance therapy integrate these mainstream treatment.
Язык: Английский
Процитировано
15
Advances in medical diagnosis, treatment, and care (AMDTC) book series, Год журнала: 2024, Номер unknown, С. 122 - 164
Опубликована: Март 11, 2024
Cancer, a critical health concern, necessitates safer, more effective treatments. This chapter explores the anticancer potential of traditional Thai plants, which, despite being underresearched, show significant promise. It focuses on bioactive compounds and their efficacy against various cancer types. The categorizes these plants based active components reviews both laboratory animal studies to understand underlying mechanisms involved in inhibiting cell growth, inducing death, preventing tumor blood vessel formation. Clinical trials supporting findings are also highlighted. Given improve or innovate treatments, present encouraging prospects. However, further research is essential confirm safety approaches. These suggest that could lead development innovative drugs, signaling advancements therapy.
Язык: Английский
Процитировано
13
Process Biochemistry, Год журнала: 2024, Номер 137, С. 217 - 228
Опубликована: Янв. 13, 2024
Язык: Английский
Процитировано
12
Molecules, Год журнала: 2024, Номер 29(10), С. 2393 - 2393
Опубликована: Май 19, 2024
The rapid advancements in nanotechnology the field of nanomedicine have potential to significantly enhance therapeutic strategies for cancer treatment. There is considerable promise enhancing efficacy therapy through manufacture innovative nanocomposite materials. Metallic nanoparticles been found release anticancer medications that are loaded onto them, resulting a sustained release, hence reducing dosage required drug administration and preventing their buildup healthy cells. combination with biocompatible materials offers new prospects development advanced therapies exhibit enhanced selectivity, reduced adverse effects, improved patient outcomes. Chitosan (CS), polysaccharide possessing distinct physicochemical properties, exhibits favorable attributes controlled delivery due its biocompatibility biodegradability. nanocomposites heightened stability, biocompatibility, prolonged characteristics medicines. incorporation gold (Au) into chitosan results manifestation photothermal characteristics, whereas inclusion silver (Ag) boosts antibacterial capabilities synthesized nanocomposite. objective this review investigate recent progress utilization Ag Au nanoparticles, or thereof, within matrix modified derivatives purpose delivery. research findings deliver various drugs, such as doxorubicin, 5-Fluroacil, curcumin, paclitaxel, 6-mercaptopurine, were investigated. Moreover, modifications carried out on phase surfaces targeting loading efficiency, pH sensitivity highlighted. In addition, challenges perspectives could motivate further related applications summarized.
Язык: Английский
Процитировано
8
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 95, С. 105562 - 105562
Опубликована: Март 11, 2024
Язык: Английский
Процитировано
7
Current Pharmaceutical Design, Год журнала: 2024, Номер 30(31), С. 2445 - 2467
Опубликована: Май 10, 2024
In recent years, the field of nanotechnology has brought about significant advancements that have transformed landscape disease diagnosis, prevention, and treatment, particularly in realm medical science. Among various approaches to nanoparticle synthesis, green synthesis method garnered increasing attention. Silver nanoparticles (AgNPs) emerged as noteworthy nanomaterials within spectrum metallic employed for biomedical applications. AgNPs possess several key attributes make them highly valuable field. They are biocompatible, cost-effective, environmentally friendly, rendering suitable bioengineering Notably, found a prominent role domain cancer diagnosis. Research investigations provided evidence AgNPs' anticancer activity, which involves mechanisms such DNA damage, cell cycle arrest, induction apoptosis, regulation specific cytokine genes. The primarily reduction silver ions by reducing agents. Interestingly, natural products living organisms proven be effective sources generation precursor materials used AgNP synthesis. This comprehensive review aims summarize aspects AgNPs, including their characterization, properties, biogenic Furthermore, highlights potential applications these combating cancer.
Язык: Английский
Процитировано
7
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 97, С. 105755 - 105755
Опубликована: Май 30, 2024
Язык: Английский
Процитировано
7