Microorganisms,
Год журнала:
2023,
Номер
11(2), С. 416 - 416
Опубликована: Фев. 7, 2023
The
constant
increase
in
temperatures
under
global
warming
has
led
to
a
prolonged
aestivation
period
for
Apostichopus
japonicus,
resulting
considerable
losses
production
and
economic
benefits.
However,
the
specific
mechanism
of
not
been
fully
elucidated.
In
this
study,
we
first
tried
illustrate
biological
mechanisms
from
perspective
gut
microbiota
metabolites.
Significant
differences
were
found
aestivating
adult
A.
japonicus
(AAJSD
group)
compared
with
nonaestivating
(AAJRT
young
(YAJRT
YAJSD
groups)
based
on
16S
rRNA
gene
high-throughput
sequencing
analysis.
abundances
Desulfobacterota,
Myxococcota,
Bdellovibrionota,
Firmicutes
(4
phyla)
AAJSD
group
significantly
increased.
Moreover,
levels
Pseudoalteromonas,
Fusibacter,
Labilibacter,
Litorilituus,
Flammeovirga,
Polaribacter,
Ferrimonas,
PB19,
Blfdi19
genera
higher
than
other
three
groups.
Further
analysis
LDA
effect
size
showed
that
species
significant
variation
abundance
group,
including
phylum
Abilibacter,
might
be
important
biomarkers
japonicus.
addition,
results
metabolomics
there
distinct
metabolic
pathways,
namely
biosynthesis
secondary
metabolites,
tryptophan
metabolism,
sesquiterpenoid
triterpenoid
Notably,
5-hydroxytryptophan
was
upregulated
metabolism
pathway.
Blfdi19,
PB19
high
positively
correlated
metabolite
5-HTP.
These
findings
suggest
may
potential
associations
among
microbiota,
This
work
provide
new
further
understanding
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(10), С. 5561 - 5561
Опубликована: Май 20, 2024
This
review
scrutinizes
the
intricate
interplay
between
microbiome
and
human
body,
exploring
its
multifaceted
dimensions
far-reaching
implications.
The
microbiome,
comprising
diverse
microbial
communities
inhabiting
various
anatomical
niches,
is
increasingly
recognized
as
a
critical
determinant
of
health
disease.
Through
an
extensive
examination
current
research,
this
elucidates
dynamic
interactions
host
physiology
across
multiple
organ
systems.
Key
topics
include
establishment
maintenance
microbiota
diversity,
influence
factors
on
composition,
bidirectional
communication
pathways
cells.
Furthermore,
we
delve
into
functional
implications
dysbiosis
in
disease
states,
emphasizing
role
shaping
immune
responses,
metabolic
processes,
neurological
functions.
Additionally,
discusses
emerging
therapeutic
strategies
aimed
at
modulating
to
restore
host–microbe
homeostasis
promote
health.
Microbiota
fecal
transplantation
represents
groundbreaking
approach
management
dysbiosis-related
diseases,
offering
promising
avenue
for
restoring
balance
within
gut
ecosystem.
innovative
therapy
involves
transfer
from
healthy
donor
individual
suffering
dysbiosis,
aiming
replenish
beneficial
populations
mitigate
pathological
imbalances.
By
synthesizing
findings
fields,
offers
valuable
insights
complex
relationship
highlighting
avenues
future
research
clinical
interventions.
Nutrients,
Год журнала:
2024,
Номер
16(14), С. 2259 - 2259
Опубликована: Июль 13, 2024
Dietary
components,
including
dietary
fiber,
unsaturated
fatty
acids,
and
polyphenols,
along
with
meal
timing
spacing,
significantly
affect
the
microbiota’s
capacity
to
produce
various
metabolites
essential
for
quality
sleep
overall
health.
This
review
explores
role
of
gut
microbiota
in
regulating
through
such
as
short-chain
tryptophan,
serotonin,
melatonin,
gamma-aminobutyric
acid.
A
balanced
diet
rich
plant-based
foods
enhances
production
these
sleep-regulating
metabolites,
potentially
benefiting
aims
investigate
how
habits
composition,
it
produces,
subsequent
impact
on
related
health
conditions.
Modern
habits
are
becoming
more
and
disruptive
to
health.
As
our
days
often
filled
with
circadian
disruption
stress
exposures,
we
need
understand
how
responses
these
external
stimuli
shaped
their
mediators
can
be
targeted
promote
A
growing
body
of
research
demonstrates
the
role
gut
microbiota
in
influencing
brain
function
behavior.
The
response
rhythms,
which
essential
maintaining
appropriate
environment,
known
impacted
by
microbiota.
Gut
microbes
have
been
shown
alter
host's
modulate
rhythmicity.
Although
studies
demonstrated
strong
links
between
microbiota,
rhythms
response,
such
were
conducted
an
independent
manner
not
conducive
understanding
interface
factors.
Due
interconnected
nature
this
review
explore
may
play
a
regulating
integration
signals
mammals
consequences
for
health
disease.
Psychological Medicine,
Год журнала:
2022,
Номер
53(8), С. 3437 - 3447
Опубликована: Фев. 7, 2022
Abstract
Background
The
potential
antidepressant
properties
of
probiotics
have
been
suggested,
but
their
influence
on
the
emotional
processes
that
may
underlie
this
effect
is
unclear.
Methods
Depressed
volunteers
(
n
=
71)
were
recruited
into
a
randomised
double-blind,
placebo-controlled
study
to
explore
effects
daily,
4-week
intake
multispecies
probiotic
or
placebo
processing
and
cognition.
Mood,
anxiety,
positive
negative
affect,
sleep,
salivary
cortisol
serum
C-reactive
peptide
(CRP)
assessed
before
after
supplementation.
Results
Compared
with
placebo,
increased
accuracy
at
identifying
faces
expressing
all
emotions
(+12%,
p
<
0.05,
total
51)
vigilance
neutral
(mean
difference
between
groups
12.28
ms
±
6.1,
51).
Probiotic
supplementation
also
reduced
reward
learning
(−9%,
51),
interference
word
recall
auditory
verbal
task
(−18%,
50),
did
not
affect
other
aspects
cognitive
performance.
Although
actigraphy
revealed
significant
group
×
night-time
activity
interaction,
follow
up
analysis
was
0.094).
Supplementation
alter
circulating
CRP
concentrations.
significantly
(−50%
from
baseline,
35)
depression
scores
Patient
Health
Questionnaire-9,
these
correlate
changes
in
processing.
Conclusions
impartiality
stimuli
observed
conventional
therapies.
Further
studies
are
required
elucidate
significance
regard
mood-improving
action
current
probiotic.
Frontiers in Microbiology,
Год журнала:
2023,
Номер
14
Опубликована: Авг. 14, 2023
Previous
research
has
reported
that
the
gut
microbiota
performs
an
essential
role
in
sleep
through
microbiome-gut-brain
axis.
However,
causal
association
between
and
remains
undetermined.We
performed
a
two-sample,
bidirectional
Mendelian
randomization
(MR)
analysis
using
genome-wide
study
summary
data
of
self-reported
traits
from
MiBioGen
consortium
UK
Biobank
to
investigate
relationships
119
bacterial
genera
seven
sleep-associated
traits.
We
calculated
effect
estimates
by
inverse-variance
weighted
(as
main
method),
maximum
likelihood,
simple
model,
median,
MR-Egger
methods,
whereas
heterogeneity
pleiotropy
were
detected
measured
MR
residual
sum
outlier
method,
Cochran's
Q
statistics,
regression.In
forward
analysis,
concluded
genetic
forecasts
relative
abundance
42
had
effects
on
In
reverse
39
genera,
13
which
overlapped
with
analysis.In
conclusion,
our
indicates
may
be
involved
regulation
sleep,
conversely,
changes
also
alter
microbiota.
These
findings
suggest
underlying
reciprocal
sleep.
Journal of Food Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 3, 2025
Abstract
Sleep
disturbances
are
increasingly
prevalent,
significantly
impacting
physical
and
mental
health.
Recent
research
reveals
a
bidirectional
relationship
between
gut
microbiota
sleep,
mediated
through
the
microbiota–gut–brain
axis.
This
review
examines
role
of
in
sleep
physiology
explores
how
biotics,
including
probiotics,
prebiotics,
synbiotics,
postbiotics,
fermented
foods,
can
enhance
quality.
Drawing
from
animal
human
studies,
we
discuss
neurobiological
mechanisms
by
which
biotics
may
influence
modulation
neurotransmitters,
immune
responses,
hormonal
regulation.
Key
microbial
metabolites,
such
as
short‐chain
fatty
acids,
highlighted
for
their
supporting
sleep‐related
neurochemical
processes.
Additionally,
this
presents
dietary
strategies
food
processing
technologies,
like
fermentation,
innovative
approaches
enhancement.
Although
promising,
available
has
limitations,
small
sample
sizes,
variability
biotic
strains
dosages,
reliance
on
subjective
assessments.
underscores
need
standardized
protocols,
objective
assessments
polysomnography,
personalized
interventions.
Emerging
findings
highlight
therapeutic
potential
improvement,
though
further
large‐scale
trials
essential
to
refine
strain
selection,
dosage,
formulation.
interdisciplinary
exploration
seeks
advance
food‐based
interventions
holistic
managing
disorders
improving
quality
life.
Metabolites,
Год журнала:
2025,
Номер
15(2), С. 70 - 70
Опубликована: Янв. 23, 2025
Background
and
objective:
Obesity
is
a
growing
global
epidemic.
The
composition
of
the
intestinal
microbiota
can
be
influenced
by
several
factors.
Studies
highlight
role
bacteria
in
pathophysiology
obesity.
So,
objective
this
study
was
to
investigate
whether
use
probiotics,
together
with
healthy
lifestyle
habits,
contributes
weight
reduction
obese
individuals
analyzing
profile.
Methods:
A
prospective
carried
out
45
adults
Participants
underwent
guidance
on
received
probiotic
component
containing
different
microbiological
strains
were
followed
for
60
days.
Clinical
parameters,
body
composition,
biochemical
analysis,
assessment
performed
before
after
treatment.
After
days,
it
observed
that
bacterial
present
patients’
microbiota.
also
showed
improvements
physical
activity,
sleep
quality,
anxiety
management,
as
well
changes
some
eating
such
consumption
processed
foods
significant
increase
water
intake.
Results:
BMI,
fasting
glucose,
insulin,
HOMA-IR,
LDL
cholesterol,
triglycerides
observed,
addition
an
HDL
improvement
bowel
movement
frequency,
stool
consistency.
Analysis
revealed
microbial
diversity
better
balance
between
phyla
Firmicutes
Bacteroidetes.
Conclusions:
related
improving
microbiota,
dietary
increased
reduced
anxiety,
quality
have
significantly
contributed
loss
physiological
parameters
individuals.
Progress in Neurobiology,
Год журнала:
2021,
Номер
209, С. 102208 - 102208
Опубликована: Дек. 16, 2021
Sleep
disorders
have
been
linked
to
alterations
of
gut
microbiota
composition
in
adult
humans
and
animal
models,
but
it
is
unclear
how
this
link
develops.
With
longitudinal
assessments
162
healthy
infants,
we
present
a
so
far
unrecognized
sleep-brain-gut
interrelationship.
First,
report
between
sleep
habits
microbiota:
daytime
associated
with
bacterial
diversity,
nighttime
fragmentation
variability
are
maturity
enterotype.
Second,
demonstrate
link:
diversity
enterotype
neurophysiology.
Third,
show
that
the
relevant
development:
markers
predict
behavioral-developmental
outcomes.
Our
results
dynamic
interplay
sleep,
microbiota,
maturation
brain
behavior
during
infancy,
which
aligns
newly
emerging
concept
axis.
Importantly,
represent
promising
health
targets
since
both
can
be
modified
non-invasively.
As
many
diseases
root
early
childhood,
leveraging
protective
factors
adequate
age-appropriate
infancy
could
constitute
promoting
factor
across
entire
human
lifespan.
Diabetes Obesity and Metabolism,
Год журнала:
2023,
Номер
25(5), С. 1203 - 1212
Опубликована: Янв. 3, 2023
To
investigate
a
prebiotic
fibre-enriched
nutritional
formula
on
health-related
quality
of
life
and
metabolic
control
in
type
2
diabetes.This
was
12-week,
double-blind,
placebo-controlled
study
with
an
unblinded
dietary
advice
only
comparator
arm.
Participants
were
randomized
2:1:1
to
(Active),
placebo
fibre-absent
(Placebo),
or
non-blinded
alone
(Diet).
Primary
endpoint
change
core
Type
Diabetes
Distress
Assessment
System
(cT2-DDAS)
at
week
12.
Glycated
haemoglobin
(HbA1c)
key
secondary
endpoint.In
total,
192
participants
randomized.
Mean
age
54.3
years,
HbA1c
7.8%,
body
mass
index
35.9
kg/m2
.
At
12,
cT2-DDAS
reduced
significantly
Active
versus
Placebo
(-0.4,
p
=
.03),
vs
(-0.64%,
.01).
Gut
microbiome
sequencing
revealed
that
the
relative
abundance
two
species
butyrate-producing
bacteria
(Roseburia
faecis
Anaerostipes
hadrus)
increased
vs.
Placebo.A
microbiome-targeting
improved
HbA1c,
suggesting
potential
for
fibre
as
complement
lifestyle
and/or
pharmaceutical
interventions
managing
diabetes.