Gut Microbiota and Metabolites may Play a Crucial Role in Sea Cucumber Apostichopus Japonicus Aestivation DOI Creative Commons
Yuan‐Huan Kang, Bintong Yang,

Ren-Ge Hu

и другие.

Microorganisms, Год журнала: 2023, Номер 11(2), С. 416 - 416

Опубликована: Фев. 7, 2023

The constant increase in temperatures under global warming has led to a prolonged aestivation period for Apostichopus japonicus, resulting considerable losses production and economic benefits. However, the specific mechanism of not been fully elucidated. In this study, we first tried illustrate biological mechanisms from perspective gut microbiota metabolites. Significant differences were found aestivating adult A. japonicus (AAJSD group) compared with nonaestivating (AAJRT young (YAJRT YAJSD groups) based on 16S rRNA gene high-throughput sequencing analysis. abundances Desulfobacterota, Myxococcota, Bdellovibrionota, Firmicutes (4 phyla) AAJSD group significantly increased. Moreover, levels Pseudoalteromonas, Fusibacter, Labilibacter, Litorilituus, Flammeovirga, Polaribacter, Ferrimonas, PB19, Blfdi19 genera higher than other three groups. Further analysis LDA effect size showed that species significant variation abundance group, including phylum Abilibacter, might be important biomarkers japonicus. addition, results metabolomics there distinct metabolic pathways, namely biosynthesis secondary metabolites, tryptophan metabolism, sesquiterpenoid triterpenoid Notably, 5-hydroxytryptophan was upregulated metabolism pathway. Blfdi19, PB19 high positively correlated metabolite 5-HTP. These findings suggest may potential associations among microbiota, This work provide new further understanding

Язык: Английский

Unraveling the Microbiome–Human Body Axis: A Comprehensive Examination of Therapeutic Strategies, Interactions and Implications DOI Open Access
Gabriel Olteanu, Maria-Alexandra Pană, Ștefan Busnatu

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(10), С. 5561 - 5561

Опубликована: Май 20, 2024

This review scrutinizes the intricate interplay between microbiome and human body, exploring its multifaceted dimensions far-reaching implications. The microbiome, comprising diverse microbial communities inhabiting various anatomical niches, is increasingly recognized as a critical determinant of health disease. Through an extensive examination current research, this elucidates dynamic interactions host physiology across multiple organ systems. Key topics include establishment maintenance microbiota diversity, influence factors on composition, bidirectional communication pathways cells. Furthermore, we delve into functional implications dysbiosis in disease states, emphasizing role shaping immune responses, metabolic processes, neurological functions. Additionally, discusses emerging therapeutic strategies aimed at modulating to restore host–microbe homeostasis promote health. Microbiota fecal transplantation represents groundbreaking approach management dysbiosis-related diseases, offering promising avenue for restoring balance within gut ecosystem. innovative therapy involves transfer from healthy donor individual suffering dysbiosis, aiming replenish beneficial populations mitigate pathological imbalances. By synthesizing findings fields, offers valuable insights complex relationship highlighting avenues future research clinical interventions.

Язык: Английский

Процитировано

13

The Role of Gut Microbiome in Sleep Quality and Health: Dietary Strategies for Microbiota Support DOI Open Access

Monika Sejbuk,

Adam Siebieszuk,

Anna Maria Witkowska

и другие.

Nutrients, Год журнала: 2024, Номер 16(14), С. 2259 - 2259

Опубликована: Июль 13, 2024

Dietary components, including dietary fiber, unsaturated fatty acids, and polyphenols, along with meal timing spacing, significantly affect the microbiota’s capacity to produce various metabolites essential for quality sleep overall health. This review explores role of gut microbiota in regulating through such as short-chain tryptophan, serotonin, melatonin, gamma-aminobutyric acid. A balanced diet rich plant-based foods enhances production these sleep-regulating metabolites, potentially benefiting aims investigate how habits composition, it produces, subsequent impact on related health conditions.

Язык: Английский

Процитировано

10

I "Gut" Rhythm: the microbiota as a modulator of the stress response and circadian rhythms DOI Creative Commons
Gabriel S. S. Tofani, Gerard Clarke, John F. Cryan

и другие.

FEBS Journal, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Modern habits are becoming more and disruptive to health. As our days often filled with circadian disruption stress exposures, we need understand how responses these external stimuli shaped their mediators can be targeted promote A growing body of research demonstrates the role gut microbiota in influencing brain function behavior. The response rhythms, which essential maintaining appropriate environment, known impacted by microbiota. Gut microbes have been shown alter host's modulate rhythmicity. Although studies demonstrated strong links between microbiota, rhythms response, such were conducted an independent manner not conducive understanding interface factors. Due interconnected nature this review explore may play a regulating integration signals mammals consequences for health disease.

Язык: Английский

Процитировано

1

Multispecies probiotic administration reduces emotional salience and improves mood in subjects with moderate depression: a randomised, double-blind, placebo-controlled study DOI Creative Commons
Rita Baião, Liliana Capitão, Cameron Higgins

и другие.

Psychological Medicine, Год журнала: 2022, Номер 53(8), С. 3437 - 3447

Опубликована: Фев. 7, 2022

Abstract Background The potential antidepressant properties of probiotics have been suggested, but their influence on the emotional processes that may underlie this effect is unclear. Methods Depressed volunteers ( n = 71) were recruited into a randomised double-blind, placebo-controlled study to explore effects daily, 4-week intake multispecies probiotic or placebo processing and cognition. Mood, anxiety, positive negative affect, sleep, salivary cortisol serum C-reactive peptide (CRP) assessed before after supplementation. Results Compared with placebo, increased accuracy at identifying faces expressing all emotions (+12%, p < 0.05, total 51) vigilance neutral (mean difference between groups 12.28 ms ± 6.1, 51). Probiotic supplementation also reduced reward learning (−9%, 51), interference word recall auditory verbal task (−18%, 50), did not affect other aspects cognitive performance. Although actigraphy revealed significant group × night-time activity interaction, follow up analysis was 0.094). Supplementation alter circulating CRP concentrations. significantly (−50% from baseline, 35) depression scores Patient Health Questionnaire-9, these correlate changes in processing. Conclusions impartiality stimuli observed conventional therapies. Further studies are required elucidate significance regard mood-improving action current probiotic.

Язык: Английский

Процитировано

37

Associations between gut microbiota and sleep: a two-sample, bidirectional Mendelian randomization study DOI Creative Commons
Jun Wu, Baofu Zhang, Shengjie Zhou

и другие.

Frontiers in Microbiology, Год журнала: 2023, Номер 14

Опубликована: Авг. 14, 2023

Previous research has reported that the gut microbiota performs an essential role in sleep through microbiome-gut-brain axis. However, causal association between and remains undetermined.We performed a two-sample, bidirectional Mendelian randomization (MR) analysis using genome-wide study summary data of self-reported traits from MiBioGen consortium UK Biobank to investigate relationships 119 bacterial genera seven sleep-associated traits. We calculated effect estimates by inverse-variance weighted (as main method), maximum likelihood, simple model, median, MR-Egger methods, whereas heterogeneity pleiotropy were detected measured MR residual sum outlier method, Cochran's Q statistics, regression.In forward analysis, concluded genetic forecasts relative abundance 42 had effects on In reverse 39 genera, 13 which overlapped with analysis.In conclusion, our indicates may be involved regulation sleep, conversely, changes also alter microbiota. These findings suggest underlying reciprocal sleep.

Язык: Английский

Процитировано

20

Appraising the role of biotics and fermented foods in gut microbiota modulation and sleep regulation DOI Open Access
Akanksha Singh, Pradeep Singh Negi

Journal of Food Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 3, 2025

Abstract Sleep disturbances are increasingly prevalent, significantly impacting physical and mental health. Recent research reveals a bidirectional relationship between gut microbiota sleep, mediated through the microbiota–gut–brain axis. This review examines role of in sleep physiology explores how biotics, including probiotics, prebiotics, synbiotics, postbiotics, fermented foods, can enhance quality. Drawing from animal human studies, we discuss neurobiological mechanisms by which biotics may influence modulation neurotransmitters, immune responses, hormonal regulation. Key microbial metabolites, such as short‐chain fatty acids, highlighted for their supporting sleep‐related neurochemical processes. Additionally, this presents dietary strategies food processing technologies, like fermentation, innovative approaches enhancement. Although promising, available has limitations, small sample sizes, variability biotic strains dosages, reliance on subjective assessments. underscores need standardized protocols, objective assessments polysomnography, personalized interventions. Emerging findings highlight therapeutic potential improvement, though further large‐scale trials essential to refine strain selection, dosage, formulation. interdisciplinary exploration seeks advance food‐based interventions holistic managing disorders improving quality life.

Язык: Английский

Процитировано

1

Synergistic Effects of Probiotics and Lifestyle Interventions on Intestinal Microbiota Composition and Clinical Outcomes in Obese Adults DOI Creative Commons
Glauber Pimentel Florêncio,

Analicy Rodrigues Xavier,

Ana Catarina de Castro Natal

и другие.

Metabolites, Год журнала: 2025, Номер 15(2), С. 70 - 70

Опубликована: Янв. 23, 2025

Background and objective: Obesity is a growing global epidemic. The composition of the intestinal microbiota can be influenced by several factors. Studies highlight role bacteria in pathophysiology obesity. So, objective this study was to investigate whether use probiotics, together with healthy lifestyle habits, contributes weight reduction obese individuals analyzing profile. Methods: A prospective carried out 45 adults Participants underwent guidance on received probiotic component containing different microbiological strains were followed for 60 days. Clinical parameters, body composition, biochemical analysis, assessment performed before after treatment. After days, it observed that bacterial present patients’ microbiota. also showed improvements physical activity, sleep quality, anxiety management, as well changes some eating such consumption processed foods significant increase water intake. Results: BMI, fasting glucose, insulin, HOMA-IR, LDL cholesterol, triglycerides observed, addition an HDL improvement bowel movement frequency, stool consistency. Analysis revealed microbial diversity better balance between phyla Firmicutes Bacteroidetes. Conclusions: related improving microbiota, dietary increased reduced anxiety, quality have significantly contributed loss physiological parameters individuals.

Язык: Английский

Процитировано

1

From Alpha Diversity to Zzz: Interactions among sleep, the brain, and gut microbiota in the first year of life DOI Creative Commons
Sarah F. Schoch, Josué L. Castro‐Mejía, Łukasz Krych

и другие.

Progress in Neurobiology, Год журнала: 2021, Номер 209, С. 102208 - 102208

Опубликована: Дек. 16, 2021

Sleep disorders have been linked to alterations of gut microbiota composition in adult humans and animal models, but it is unclear how this link develops. With longitudinal assessments 162 healthy infants, we present a so far unrecognized sleep-brain-gut interrelationship. First, report between sleep habits microbiota: daytime associated with bacterial diversity, nighttime fragmentation variability are maturity enterotype. Second, demonstrate link: diversity enterotype neurophysiology. Third, show that the relevant development: markers predict behavioral-developmental outcomes. Our results dynamic interplay sleep, microbiota, maturation brain behavior during infancy, which aligns newly emerging concept axis. Importantly, represent promising health targets since both can be modified non-invasively. As many diseases root early childhood, leveraging protective factors adequate age-appropriate infancy could constitute promoting factor across entire human lifespan.

Язык: Английский

Процитировано

34

A microbiome‐targeting fibre‐enriched nutritional formula is well tolerated and improves quality of life and haemoglobin A1c in type 2 diabetes: A double‐blind, randomized, placebo‐controlled trial DOI Creative Commons
Juan P. Frías, Martin L. Lee, Matthew M. Carter

и другие.

Diabetes Obesity and Metabolism, Год журнала: 2023, Номер 25(5), С. 1203 - 1212

Опубликована: Янв. 3, 2023

To investigate a prebiotic fibre-enriched nutritional formula on health-related quality of life and metabolic control in type 2 diabetes.This was 12-week, double-blind, placebo-controlled study with an unblinded dietary advice only comparator arm. Participants were randomized 2:1:1 to (Active), placebo fibre-absent (Placebo), or non-blinded alone (Diet). Primary endpoint change core Type Diabetes Distress Assessment System (cT2-DDAS) at week 12. Glycated haemoglobin (HbA1c) key secondary endpoint.In total, 192 participants randomized. Mean age 54.3 years, HbA1c 7.8%, body mass index 35.9 kg/m2 . At 12, cT2-DDAS reduced significantly Active versus Placebo (-0.4, p = .03), vs (-0.64%, .01). Gut microbiome sequencing revealed that the relative abundance two species butyrate-producing bacteria (Roseburia faecis Anaerostipes hadrus) increased vs. Placebo.A microbiome-targeting improved HbA1c, suggesting potential for fibre as complement lifestyle and/or pharmaceutical interventions managing diabetes.

Язык: Английский

Процитировано

15

Efficacy and safety of fecal microbiota transplantation for chronic insomnia in adults: a real world study DOI Creative Commons
Haiming Fang, Tingting Yao, Wanli Li

и другие.

Frontiers in Microbiology, Год журнала: 2023, Номер 14

Опубликована: Ноя. 21, 2023

Objective To assess the efficacy and safety of fecal microbiota transplantation (FMT) for adult chronic insomnia. Methods Patients treated with FMT diseases were divided into insomnia non-insomnia group. The primary endpoint was 4 weeks after treatment, secondary endpoints included impacts on anxiety, depression, health-related quality life, gut microbiota, adverse events associated FMT. Insomnia Severity Index (ISI) Pittsburgh Sleep Quality (PSQI) utilized to insomnia, self-rating anxiety/depression scale [Zung Self-Rating Anxiety Scale (SAS), Zung Depression (SDS)] employed evaluate anxiety depression. life evaluated by SF-36. 16S rRNA sequencing analyze correlation analysis performed. Results Forty patients met inclusion criteria seven excluded. 33 enrolled stratified group ( N = 17) 16). Compared baseline, significantly ameliorated ISI (17.31 ± 5.12 vs. 5.38 5.99), PSQI (14.56 2.13 6.63 4.67), SAS (54.25 8.90 43.68 10.64) SDS (57.43 10.96 50.68 15.27) score patients. 76.47% (13/17) achieved endpoints. In patients, relative abundance Eggerthella marked enhanced at while Lactobacillus, Bifidobacterium, Turicibacter, Anaerostipes , Eisenbergiella increased latter positive correlated Encouragingly, also improved sleep Conclusion may potentially serve as a distinctive genus maybe novel treatment option adults provide an alternative traditional treatments effects augmentation probiotics, such Bifidobacterium Lactobacillus Turicibacter Fusobacterium .

Язык: Английский

Процитировано

15