Gut microbiome-targeted therapies for Alzheimer’s disease

Gut Microbes, Год журнала: 2023, Номер 15(2)

Опубликована: Ноя. 7, 2023

The advent of high­throughput ‘omics’ technologies has improved our knowledge gut microbiome in human health and disease, including Alzheimer’s disease (AD), a neurodegenerative disorder. Frequent bidirectional communications mutual regulation exist between the gastrointestinal tract central nervous system through gut-brain axis. A large body research reported close association microbiota AD development, restoring healthy may curb or even improve symptoms progression. Thus, modulation become novel paradigm for clinical management AD, emerging effort focused on developing potential strategies preventing and/or treating disease. In this review, we provide an overview connection causal relationship dysbiosis mechanisms driving progression, successes challenges implementing available microbiome-targeted therapies (including probiotics, prebiotics, synbiotics, postbiotics, fecal transplantation) preventive therapeutic preclinical intervention studies AD. Finally, discuss future directions field.

Язык: Английский

---

Beneficial microorganisms: Regulating growth and defense for plant welfare

Plant Biotechnology Journal, Год журнала: 2024, Номер unknown

Опубликована: Дек. 20, 2024

Beneficial microorganisms (BMs) promote plant growth and enhance stress resistance. This review summarizes how BMs induce promotion by improving nutrient uptake, producing growth-promoting hormones stimulating root development. How disease resistance help protect plants from abiotic stresses has also been explored. Growth-defense trade-offs are known to affect the ability of survive under unfavourable conditions. discusses studies demonstrating that regulate growth-defense through microbe-associated molecular patterns multiple pathways, including leucine-rich repeat receptor-like kinase pathway, abscisic acid signalling pathway specific transcriptional factor regulation. multifaceted relationship underscores significance in sustainable agriculture. Finally, need for integration artificial intelligence revolutionize biofertilizer research highlighted. elucidates cutting-edge advancements potential plant-microbe synergistic microbial agents.

Язык: Английский

---

Genome-resolved metagenomics: a game changer for microbiome medicine

Experimental & Molecular Medicine, Год журнала: 2024, Номер 56(7), С. 1501 - 1512

Опубликована: Июль 1, 2024

Abstract Recent substantial evidence implicating commensal bacteria in human diseases has given rise to a new domain biomedical research: microbiome medicine. This emerging field aims understand and leverage the microbiota derivative molecules for disease prevention treatment. Despite complex hierarchical organization of this ecosystem, most research over years relied on 16S amplicon sequencing, legacy bacterial phylogeny taxonomy. Although advanced sequencing technologies have enabled cost-effective analysis entire microbiota, translating relatively short nucleotide information into functional taxonomic posed challenges until recently. In last decade, genome-resolved metagenomics, which reconstruct microbial genomes directly from whole-metagenome data, made significant strides continues unveil mysteries various human-associated communities. There been rapid increase volume whole metagenome data compilation novel metagenome-assembled protein sequences public depositories. review provides an overview capabilities methods metagenomics studying microbiome, with focus investigating prokaryotic gut. Just as decoding genome its variations marked beginning genomic medicine era, unraveling microbes their sequence is ushering us era Genome-resolved stands pivotal tool transition can accelerate our journey toward achieving these scientific medical milestones.

Язык: Английский

---

The association between the dietary index for gut microbiota and metabolic dysfunction-associated fatty liver disease: a cross-sectional study

Diabetology & Metabolic Syndrome, Год журнала: 2025, Номер 17(1)

Опубликована: Янв. 17, 2025

The relationship between the gut microbiome and metabolic dysfunction-associated fatty liver disease (MAFLD) has garnered increasing attention. However, association dietary index for microbiota (DI-GM), a measure of diversity, MAFLD yet to be fully explored. Data from 2017-2020 National Health Nutrition Examination Survey (NHANES) were analyzed, including 7243 participants. DI-GM was investigated using weighted logistic regression, restricted cubic spline (RCS), subgroup analyses. A notable inverse identified prevalence MAFLD, with each 1-point increase in corresponding 6.1% reduction (OR = 0.939, 95% CI: 0.901-0.980). Individuals score 6 or higher had an adjusted OR 0.794 (95% 0.665-0.947) compared those 0-3. RCS analysis further revealed linear risk. Additionally, analyses suggested that race may modify (P interaction < 0.05). is inversely associated prevalence, appears significant modifier this relationship.

Язык: Английский

---

Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota

Biomolecules, Год журнала: 2025, Номер 15(2), С. 270 - 270

Опубликована: Фев. 12, 2025

The gut-brain-cancer axis represents a novel and intricate connection between the gut microbiota, neurobiology, cancer progression. Recent advances have accentuated significant role of microbiota metabolites in modulating systemic processes that influence both brain health tumorigenesis. This paper explores emerging concept metabolite-mediated modulation within connection, focusing on key such as short-chain fatty acids (SCFAs), tryptophan derivatives, secondary bile acids, lipopolysaccharides (LPS). While microbiota's impact immune regulation, neuroinflammation, tumor development is well established, gaps remain grasping how specific contribute to neuro-cancer interactions. We discuss with potential implications for neurobiology cancer, indoles polyamines, which yet be extensively studied. Furthermore, we review preclinical clinical evidence linking dysbiosis, altered metabolite profiles, tumors, showcasing limitations research gaps, particularly human longitudinal studies. Case studies investigating microbiota-based interventions, including dietary changes, fecal transplantation, probiotics, demonstrate promise but also indicate hurdles translating these findings therapies. concludes call standardized multi-omics approaches bi-directional frameworks integrating microbiome, neuroscience, oncology develop personalized therapeutic strategies patients.

Язык: Английский

---

Critical Review of the Cross-Links Between Dietary Components, the Gut Microbiome, and Depression

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 614 - 614

Опубликована: Янв. 13, 2025

The complex relationship between diet, the gut microbiota, and mental health, particularly depression, has become a focal point of contemporary research. This critical review examines how specific dietary components, such as fiber, proteins, fats, vitamins, minerals, bioactive compounds, shape microbiome influence microbial metabolism in order to regulate depressive outcomes. These dietary-induced changes microbiota can modulate production metabolites, which play vital roles gut–brain communication. axis facilitates this communication through neural, immune, endocrine pathways. Alterations metabolites central nervous system (CNS) functions by impacting neuroplasticity, inflammatory responses, neurotransmitter levels—all are linked onset course depression. highlights recent findings linking components with beneficial composition reduced symptoms. We also explore challenges individual variability responses interventions long-term sustainability these strategies. underscores necessity for further longitudinal mechanistic studies elucidate precise mechanisms diet interactions be leveraged mitigate paving way personalized nutritional therapies.

Язык: Английский

---

Bridging gap in the treatment of Alzheimer’s disease via postbiotics: Current practices and future prospects

Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102689 - 102689

Опубликована: Фев. 1, 2025

Язык: Английский

---

A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH

Cell Metabolism, Год журнала: 2024, Номер 36(8), С. 1823 - 1838.e6

Опубликована: Июль 29, 2024

Язык: Английский

---

The gut microbiota–brain axis in neurological disorders

MedComm, Год журнала: 2024, Номер 5(8)

Опубликована: Июль 20, 2024

Abstract Previous studies have shown a bidirectional communication between human gut microbiota and the brain, known as microbiota–gut–brain axis (MGBA). The MGBA influences host's nervous system development, emotional regulation, cognitive function through neurotransmitters, immune modulation, metabolic pathways. Factors like diet, lifestyle, genetics, environment shape composition together. Most research explored how regulates host physiology its potential in preventing treating neurological disorders. However, individual heterogeneity of microbiota, strains playing dominant role diseases, interactions these microbial metabolites with central/peripheral systems still need exploration. This review summarizes driving neurodevelopmental disorders (autism spectrum disorder attention deficit/hyperactivity disorder), neurodegenerative diseases (Alzheimer's Parkinson's disease), mood (anxiety depression) recent years discusses current clinical preclinical microbe‐based interventions, including dietary intervention, probiotics, prebiotics, fecal transplantation. It also puts forward insufficient on provides framework for further

Язык: Английский

---

Resveratrol Improves Hyperuricemia and Ameliorates Renal Injury by Modulating the Gut Microbiota

Nutrients, Год журнала: 2024, Номер 16(7), С. 1086 - 1086

Опубликована: Апрель 7, 2024

Resveratrol (RES) has been reported to prevent hyperuricemia (HUA); however, its effect on intestinal uric acid metabolism remains unclear. This study evaluated the impact of RES in mice with HUA induced by a high-fat diet (HFD). Moreover, we revealed underlying mechanism through metagenomics, fecal microbiota transplantation (FMT), and 16S ribosomal RNA analysis. We demonstrated that reduced serum acid, creatinine, urea nitrogen, urinary protein levels, improved glomerular atrophy, unclear renal tubule structure, fibrosis, inflammation. The results also showed increased degradation. significantly changed flora composition HFD-fed enriching beneficial bacteria degrade reducing harmful promote inflammation, improving microbial function via upregulation purine metabolism. FMT further is essential for HUA, Lactobacillus may play key role this process. present alleviates HFD-induced injury regulating gut acid.

Язык: Английский

---