Early life gut microbiome and its impact on childhood health and chronic conditions

Gut Microbes, Год журнала: 2025, Номер 17(1)

Опубликована: Фев. 7, 2025

The development of the gut microbiome is crucial to human health, particularly during first three years life. Given its role in immune development, disturbances establishment process may have long term consequences. This review summarizes evidence for these claims, highlighting compositional changes this critical period life as well factors that affect development. Based on and animal data, we conclude early-life a determinant long-term impacting physiological, metabolic, processes. field faces challenges. Some challenges are technical, such lack standardized stool collection protocols, inconsistent DNA extraction methods, outdated sequencing technologies. Other methodological: small sample sizes, longitudinal studies, poor control confounding variables. To address limitations, advocate more robust research methodologies better understand microbiome's health disease. Improved methods will lead reliable studies deeper understanding impact outcomes.

Язык: Английский

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The Effect of Oral Microbiota on the Severity and Prognosis of Stroke

Bulletin of Science and Practice, Год журнала: 2025, Номер 11(1), С. 124 - 145

Опубликована: Янв. 15, 2025

The microbiome of the oral cavity plays an important role in development and progression various somatic diseases, including stroke. Studies show that bacteria living can enter bloodstream contribute to inflammatory processes, which increases risk cardiovascular disease It was found 79% studied stroke-related blood clots, DNA commonly cavity, such as streptococci Viridans species, found. Periodontal pathogenic microorganisms cause chronic inflammation atherosclerosis, is one main factors for Dysbiosis also associated with increase level proinflammatory cytokines, worsen condition vessels likelihood thrombosis. Thus, maintaining health timely treatment dental diseases have a significant impact on reducing Understanding relationship between state system opens up new horizons preventive measures therapeutic approaches patients at high

Язык: Английский

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Modeling Microbial Communities: Perspective and Challenges

ACS Synthetic Biology, Год журнала: 2024, Номер 13(8), С. 2260 - 2270

Опубликована: Авг. 16, 2024

Microbial communities are immensely important due to their widespread presence and profound impact on various facets of life. Understanding these complex systems necessitates mathematical modeling, a powerful tool for simulating predicting microbial community behavior. This review offers critical analysis metabolic modeling highlights key areas that would greatly benefit from broader discussion collaboration. Moreover, we explore the challenges opportunities linked intricate nature communities, spanning data generation, validation. We confident ongoing advancements in techniques, such as machine learning, coupled with interdisciplinary collaborations, will unlock full potential across diverse applications.

Язык: Английский

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Oral Microbiome Dysbiosis as a Risk Factor for Stroke: A Comprehensive Review

Microorganisms, Год журнала: 2024, Номер 12(8), С. 1732 - 1732

Опубликована: Авг. 22, 2024

Stroke represents a significant global health burden, with substantial impact on mortality, morbidity, and long-term disability. The examination of stroke biomarkers, particularly the oral microbiome, offers promising avenue for advancing our understanding factors that contribute to risk developing strategies mitigate risk. This review highlights correlations between diseases, such as periodontitis caries, onset stroke. Periodontal pathogens within microbiome have been identified contributing factor in exacerbation stroke, including obesity, dyslipidemia, atherosclerosis, hypertension, endothelial dysfunction. alteration may these conditions, emphasizing vital role prevention cardiovascular disease. integration dental medical practices enhancing efforts improving patient outcomes.

Язык: Английский

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Unveiling the Resistome Landscape in Peri-Implant Health and Disease

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(3), С. 931 - 931

Опубликована: Янв. 31, 2025

Background: The human oral microbiome is a critical reservoir for antibiotic resistance; however, subgingival peri-implant biofilms remain underexplored in this context. We aimed to explore the prevalence and distribution of resistance genes (ARGs) metagenomes derived from saliva biofilms. Methods: A total 100 metagenome datasets 40 individuals were retrieved Sequence Read Archive (SRA) database. Of these, 20 had exclusively healthy implants both affected with peri-implantitis. ARGs their taxonomic assignments identified using ABRicate tool, plasmid detection was performed PlasmidFinder. Results: Four replicons 72 metagenomes, 55 distinct 13 classes detected 89 metagenomes. conferring macrolides-lincosamides-streptogramins, tetracyclines, beta-lactams, fluoroquinolones most prevalent. msr(D) mef(A) showed highest prevalence, except samples implants, where ranked fourth. pairwise PERMANOVA principal coordinate analysis based on Jaccard distances revealed that exhibited significantly greater ARG diversity than biofilm (p < 0.05). However, no significant differences observed between peri-implantitis-affected groups > origins also analyzed understand potential impact microbial communities. Conclusions: Resistome profiles associated health disease higher salivary abundance compared samples.

Язык: Английский

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Unveiling the microbial influence: bacteria’s dual role in tumor metastasis

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Март 14, 2025

As cancer research advances, the intricate relationship between microbiome and is gaining heightened recognition, especially concerning tumor metastasis, where bacterial involvement becomes increasingly complex. This review seeks to systematically examine dual roles of bacteria in metastasis process, encompassing both mechanisms that facilitate inhibitory effects exerted by specific microorganisms. We explore through which influence cell migration inducing chronic inflammation, evading host immune responses, remodeling ECM. Moreover, immunomodulatory potential probiotics genetically engineered offers promising prospects for prevention treatment metastasis. article elucidates complexity emerging frontiers examining clinical significance as biomarkers evaluating antibiotic usage on metastatic process. posit comprehending biological characteristics bacteria, a critical component microenvironment, will offer innovative strategies theoretical foundations treatment. Furthermore, this explores future directions, including application technologies bacteria-based therapeutic strategies, thereby offering valuable perspective development novel anti-cancer approaches.

Язык: Английский

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Operationalizing Team Science at the Academic Cancer Center Network to Unveil the Structure and Function of the Gut Microbiome

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(6), С. 2040 - 2040

Опубликована: Март 17, 2025

Oncologists increasingly recognize the microbiome as an important facilitator of health well a contributor to disease, including, specifically, cancer. Our knowledge etiologies, mechanisms, and modulation states that ameliorate or promote cancer continues evolve. The progressive refinement adoption “omic” technologies (genomics, transcriptomics, proteomics, metabolomics) utilization advanced computational methods accelerate this evolution. academic center network, with its immediate access extensive, multidisciplinary expertise scientific resources, has potential catalyze research. Here, we review our current understanding role gut in prevention, predisposition, response therapy. We underscore promise operationalizing network uncover structure function microbiome; highlight unique microbiome-related expert resources available at City Hope Comprehensive Cancer Center example team science achieve novel clinical discovery.

Язык: Английский

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BGC heteroexpression strategy for production of novel microbial secondary metabolites

Metabolic Engineering, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Refining microbiome diversity analysis by concatenating and integrating dual 16S rRNA amplicon reads

npj Biofilms and Microbiomes, Год журнала: 2025, Номер 11(1)

Опубликована: Апрель 12, 2025

Understanding the role of human gut microbiota in health and disease requires insights into its taxonomic composition functional capabilities. This study evaluates whether concatenating paired-end reads enhances data output for microbiome analysis compared to merging approach across various regions 16S rRNA gene. We assessed this both mock communities Korean cohorts with or without ulcerative colitis. Our results indicate that using direct joining method V1-V3 V6-V8 improves resolution (ME) post-sequencing data. While predicting microbial function based on sequencing has inherent limitations, integrating from enhanced predictions. was confirmed by whole metagenome (WMS) cohorts, where our improved taxa detection lost ME method. Thus, we propose integrated dual technique serves as a valuable tool research bridging gap between amplicon WMS.

Язык: Английский

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Gut Microbes Libraries: A Key Resource for Current Gut Microbiome Research

Journal of Bacteriology and Virology, Год журнала: 2025, Номер 55(1), С. 1 - 9

Опубликована: Март 31, 2025

Язык: Английский

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