Macrophage polarization and its impact on idiopathic pulmonary fibrosis
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 26, 2024
Idiopathic
pulmonary
fibrosis
(IPF)
is
a
lung
disease
that
worsens
over
time,
causing
in
the
lungs
and
ultimately
resulting
respiratory
failure
high
risk
of
death.
Macrophages
play
crucial
role
immune
system,
showing
flexibility
by
transforming
into
either
pro-inflammatory
(M1)
or
anti-inflammatory
(M2)
macrophages
when
exposed
to
different
stimuli,
impacting
development
IPF.
Recent
research
has
indicated
polarization
onset
progression
M1
secrete
inflammatory
cytokines
agents
early
damage
fibrosis,
while
M2
support
tissue
healing
releasing
cytokines.
Developing
novel
treatments
for
IPF
relies
on
thorough
comprehension
processes
involved
macrophage
The
review
outlines
regulation
its
impact
IPF,
with
goal
investigating
possible
therapeutic
benefits
advancement
Язык: Английский
Integrative analysis of genomic and epigenomic regulation reveals miRNA mediated tumor heterogeneity and immune evasion in lower grade glioma
Communications Biology,
Год журнала:
2024,
Номер
7(1)
Опубликована: Июль 6, 2024
Abstract
The
expression
dysregulation
of
microRNAs
(miRNA)
has
been
widely
reported
during
cancer
development,
however,
the
underling
mechanism
remains
largely
unanswered.
In
present
work,
we
performed
a
systematic
integrative
study
for
genome-wide
DNA
methylation,
copy
number
variation
and
miRNA
data
to
identify
mechanisms
underlying
in
lower
grade
glioma.
We
719
miRNAs
whose
was
associated
with
alterations
or
promoter
methylation.
Integrative
multi-omics
analysis
revealed
four
subtypes
differing
prognoses.
These
glioma
exhibited
distinct
immune-related
characteristics
as
well
clinical
genetic
features.
By
construction
regulatory
network,
identified
candidate
immune
evasion
response
immunotherapy.
Finally,
eight
prognosis
related
were
validated
promote
cell
migration,
invasion
proliferation
through
vitro
experiments.
Our
reveals
crosstalk
among
regulation
glioma,
could
have
important
implications
patient
stratification
development
biomarkers
immunotherapy
approaches.
Язык: Английский
Epigenetic regulation of tumor immunity
Journal of Clinical Investigation,
Год журнала:
2024,
Номер
134(12)
Опубликована: Июнь 16, 2024
Although
cancer
has
long
been
considered
a
genetic
disease,
increasing
evidence
shows
that
epigenetic
aberrations
play
crucial
role
in
affecting
tumor
biology
and
therapeutic
response.
The
dysregulated
epigenome
cells
reprograms
the
immune
landscape
within
microenvironment,
thereby
hindering
antitumor
immunity,
promoting
progression,
inducing
immunotherapy
resistance.
Targeting
epigenetically
mediated
tumor-immune
crosstalk
is
an
emerging
strategy
to
inhibit
progression
circumvent
limitations
of
current
immunotherapies,
including
checkpoint
inhibitors.
In
this
Review,
we
discuss
mechanisms
by
which
regulate
interactions
how
targeted
therapies
synergize
with
immunotherapy.
Язык: Английский
Protease regulation of tumor-immune cell symbiosis
Trends in cancer,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Translocator protein (TSPO) in glioma: implications for diagnosis, disease progression monitoring, and targeted therapies
Exploration of neuroscience,
Год журнала:
2025,
Номер
4
Опубликована: Апрель 1, 2025
Glioma
is
a
highly
aggressive
brain
cancer
associated
with
significant
mortality.
Despite
advances
in
diagnostic
and
therapeutic
strategies,
the
prognosis
for
glioma
patients
remains
poor
due
to
limited
accuracy
monitoring
capabilities.
Translocator
protein
(TSPO)
mitochondrial
implicated
various
cancers,
including
glioma,
where
it
plays
role
cell
survival,
proliferation,
chemo-resistance.
This
review
article
aimed
comprehensively
analyze
of
TSPO
particularly
its
potential
applications
enhancing
methods
strategies.
Molecular
imaging
techniques
have
emerged
as
promising
tools
non-invasive
diagnosis,
disease
progression
monitoring,
treatment
selection
gliomas.
A
comprehensive
literature
was
conducted
explore
TSPO’s
expression
patterns,
biological
functions,
molecular
imaging.
Studies
utilizing
positron
emission
tomography
(PET),
single
photon
computed
(SPECT),
magnetic
resonance
(MRI),
other
modalities
were
included.
overexpressed
cells,
high-grade
tumors,
correlating
tumor
aggressiveness
patient
prognosis.
TSPO-targeted
agents
demonstrate
high
specificity
sensitivity
detection,
positioning
marker
accurate
diagnosis
monitoring.
Future
studies
should
focus
on
optimizing
protocols,
validating
their
clinical
utility,
exploring
combined
improve
precision.
Язык: Английский
Long Non-Coding RNA AGAP2-AS1: A Comprehensive Overview on Its Biological Functions and Clinical Significances in Human Cancers
Molecules,
Год журнала:
2024,
Номер
29(15), С. 3461 - 3461
Опубликована: Июль 24, 2024
Long
non-coding
RNAs
(lncRNAs)
are
well
known
for
their
oncogenic
or
anti-oncogenic
roles
in
cancer
development.
Язык: Английский