Current Issues in Molecular Biology,
Год журнала:
2022,
Номер
44(8), С. 3413 - 3427
Опубликована: Июль 30, 2022
Excessive
lipid
deposition
in
layer
chickens
due
to
inappropriate
feeding
adversely
affects
egg
production;
however,
nutritional
manipulation
methods
deal
with
this
issue
are
still
limited.
β-hydroxy-β-methylbutyrate
(HMB),
a
metabolite
of
L-leucine,
was
recently
reported
as
lipid-lowering
nutrient
mice
and
pigs,
although
its
role
layers
had
not
been
investigated.
Here,
we
employed
high-fat
high-cholesterol
diet
(HFHCD)-challenged
growing
an
obese
model
explore
HMB
function
the
regulation
metabolism
potential
mechanisms
involved.
We
found
that
dietary
supplementation
(0.05%
or
0.10%)
significantly
reduced
HFHCD-induced
bodyweight
growth
layers,
mainly
reduction
abdominal
fat
deposition.
Mechanistically,
enhanced
hepatic
bile
acid
synthesis
from
cholesterol
through
elevating
expression
Cyp7a1,
gene
coding
key
enzyme
synthesis.
Furthermore,
16S
rRNA
sequencing
revealed
remodeled
diversity
composition
layers'
cecal
microbiota,
abundance
Bacteroidetes
at
phylum
level
were
especially
affected.
Correlation
analysis
further
indicated
strong
negative
association
between
metabolism-related
parameters.
Taken
together,
these
data
suggest
could
improve
probably
modulating
gut
microbiota
function.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2022,
Номер
64(4), С. 909 - 927
Опубликована: Авг. 18, 2022
The
gut
microbiota
(GM)
is
a
complex
ecosystem
that
closely
linked
to
host
health.
Ganoderma
spp.
polysaccharides
(GPs),
major
bioactive
component
of
the
fungal
genus
Ganoderma,
can
modulate
GM,
exhibiting
various
health
effects
and
prebiotic
potential.
This
review
comprehensively
concluded
structural
features
extraction
method
GPs.
mechanism
GPs
for
anti-obesity,
anti-diabetes,
anti-inflammatory,
anti-cancer
were
further
evaluated.
simulated
gastrointestinal
digestion
utilization
microorganisms
discussed.
It
was
found
physicochemical
properties
biological
activities
depend
on
their
characteristics
(molecular
weight,
monosaccharide
composition,
glycosidic
bonds,
etc.).
Their
also
affects
structure
bioactivities
polysaccharides.
supplementation
could
increase
relative
abundance
beneficial
bacteria
(e.g.
Bacteroides,
Parabacteroides,
Akkermansia,
Bifidobacterium),
while
reducing
pathogenic
Aerococcus,
Ruminococcus),
thus
promoting
Moreover,
are
resistant
in
stomach
small
intestine
but
digested
large
intestine.
Therefore,
be
considered
as
potential
prebiotics.
However,
studies
should
investigate
how
prebiotics
regulate
GM
improve
The American Journal of Gastroenterology,
Год журнала:
2024,
Номер
119(6), С. 1038 - 1046
Опубликована: Фев. 19, 2024
The
metabolic
syndrome
(MetSyn)
is
currently
one
of
the
biggest
global
health
challenges
because
its
impact
on
public
health.
MetSyn
includes
cluster
disorders
including
obesity,
high
blood
pressure,
hyperglycemia,
triglyceride
levels,
and
hepatic
steatosis.
Together,
these
abnormalities
increase
cardiovascular
risk
individuals
pose
a
threat
to
healthcare
systems
worldwide.
To
better
understand
address
this
complex
issue,
recent
research
has
been
increasingly
focusing
unraveling
delicate
interplay
between
intestines
more
specifically
our
gut
microbiome.
microbiome
entails
all
microorganisms
inhabiting
gastrointestinal
tract
plays
pivotal
role
in
processes
overall
host.
Emerging
evidence
proves
an
association
composition
aspects
MetSyn,
such
as
obesity.
Understanding
relationships
crucial
they
offer
valuable
insights
into
mechanisms
underlying
development
progression
possible
treatment
options.
Yet,
how
should
we
interpret
relationship?
This
review
focuses
MetSyn.
In
addition,
have
reviewed
existing
with
disorders,
attempt
interactions
nature
association.
We
also
explored
potential
therapeutic
options
targeting
modify
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(15), С. 8352 - 8352
Опубликована: Июль 30, 2024
Adipose
tissue
dysfunction,
which
is
associated
with
an
increased
risk
of
colorectal
cancer
(CRC),
a
significant
factor
in
the
pathophysiology
obesity.
Obesity-related
inflammation
and
extracellular
matrix
(ECM)
remodeling
promote
metastasis
(CRCM)
by
shaping
tumor
microenvironment
(TME).
When
CRC
occurs,
metabolic
symbiosis
cells
recruits
adjacent
adipocytes
into
TME
to
supply
energy.
Meanwhile,
abundant
immune
cells,
from
adipose
blood,
are
recruited
TME,
stimulated
pro-inflammatory
factors
triggers
chronic
local
TME.
Dysregulated
ECM
proteins
cell
surface
adhesion
molecules
enhance
further
increase
contractibility
between
stromal
promotes
epithelial-mesenchymal
transition
(EMT).
EMT
increases
migration
invasion
surrounding
tissues
or
vessels
accelerates
CRCM.
Colorectal
symbiotic
microbiota
also
plays
important
role
promotion
In
this
review,
we
provide
its
contributions
CRC,
special
emphasis
on
adipocytes,
macrophages,
neutrophils,
T
ECM,
gut
progression
their
microenvironment.
We
highlight
interactions
potential
therapeutic
approaches
target
these
interactions.
International Journal of Clinical and Health Psychology,
Год журнала:
2022,
Номер
23(2), С. 100349 - 100349
Опубликована: Дек. 14, 2022
Moving
towards
a
systems
psychiatry
paradigm
embraces
the
inherent
complex
interactions
across
all
levels
from
micro
to
macro
and
necessitates
an
integrated
approach
treatment.
Cortical
5-HT
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(3), С. 1849 - 1849
Опубликована: Янв. 17, 2023
Cancer
cachexia
is
a
complex
multifactorial
syndrome
whose
hallmarks
are
weight
loss
due
to
the
wasting
of
muscle
tissue
with
or
without
adipose
tissue,
anorexia,
systemic
inflammation,
and
multi-organ
metabolic
alterations,
which
negatively
impact
patients'
response
anticancer
treatments,
quality
life,
overall
survival.
Despite
its
clinical
relevance,
cancer
often
remains
an
underestimated
complication
lack
rigorous
diagnostic
therapeutic
pathways.
A
number
studies
have
shown
alterations
in
gut
microbiota
diversity
composition
association
markers
symptoms,
thus
supporting
central
role
for
dysbiosis
pathogenesis
this
syndrome.
Different
tools
manipulation,
including
probiotics,
prebiotics,
synbiotics,
fecal
transplantation,
been
investigated,
demonstrating
encouraging
improvements
outcomes.
Albeit
pioneering,
these
pave
way
future
research
aim
exploring
more
deeply
setting
up
effective
microbiota-targeting
interventions
be
translated
into
practice.
Journal of Neuroendocrinology,
Год журнала:
2023,
Номер
35(9)
Опубликована: Фев. 15, 2023
Oxytocin
is
a
peptide-hormone
extensively
studied
for
its
multifaceted
biological
functions
and
has
recently
gained
attention
role
in
eating
behavior,
through
action
as
an
anorexigenic
neuropeptide.
Moreover,
the
gut
microbiota
involved
oxytocinergic
signaling
brain-gut
axis,
specifically
regulation
of
social
behavior.
The
also
implicated
appetite
postulated
to
play
central
hedonic
eating.
In
this
review,
we
provide
overview
on
oxytocin
individual
links
with
microbiome,
homeostatic
non-homeostatic
behavior
well
stress.
International Journal of Obesity,
Год журнала:
2023,
Номер
47(11), С. 1029 - 1042
Опубликована: Сен. 6, 2023
Abstract
Background
Probiotics
are
commonly
used
after
bariatric
surgery.
However,
uncertainty
remains
regarding
their
effects.
The
purpose
of
this
systematic
review
was
to
assess
the
effect
probiotics
in
patients
with
morbid
obesity
undergoing
Methods
PubMed,
Cochrane
Library,
Embase,
Science
Direct,
and
Web
were
searched
from
inception
April
4,
2023.
No
language
restrictions
applied.
Relevant
randomized
controlled
trials
clinical
included.
We
aggregated
data
extracted
assessed
heterogeneity.
When
severe
heterogeneity
detected,
a
random
model
used.
All
stages
done
by
independent
authors.
Results
screened
2024
references
included
11
trials.
Compared
protocol
groups,
showed
significant
effects
on
regulating
aspartate
amino
transferase
level
(MD
=
−4.32
U/L;
95%
CI
[−7.10,
−1.53],
p
0.002),
triglycerides
−20.16
mg/dL;
[−34.51,
−5.82],
0.006),
weight
−1.99
kg;
[−3.97,
−0.01],
0.05),
vitamin
B
12
2.24
pg/dL;
[−0.02,
4.51],
dietary
energy
−151.03
kcal;
[−215.68,
−86.37],
<
0.00001),
protein
−4.48
g/day,
[−8.76,
−0.20],
0.04),
carbohydrate
−34.25
[−44.87,
−23.62],
fiber
−2.17
[−3.21,
−1.14],
0.0001).
There
no
side
related
probiotics.
Conclusions
Our
meta-analysis
suggested
that
may
delay
progression
liver
function
injury,
improve
lipid
metabolism,
reduce
weight,
food
intake,
although
other
indicators
insignificant.
be
helpful
for
registered
PROSPERO
(International
prospective
register
reviews):
CRD42023407970.
primary
source
funding.
The Journal of Physiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 22, 2025
Abstract
The
complex
microbial
community
residing
in
the
human
gut
has
long
been
understood
to
regulate
gastrointestinal
physiology
and
participate
digestive
diseases,
but
its
extraintestinal
actions
influences
are
increasingly
recognized.
This
article
discusses
bidirectional
interactions
between
microbiome
athletic
performance,
metabolism,
longevity
ability
of
gut–brain
axis
influence
cognitive
function
mental
health.
image
BIO Web of Conferences,
Год журнала:
2025,
Номер
153, С. 03009 - 03009
Опубликована: Янв. 1, 2025
Background:
Colon
cancer
ranks
as
the
5
th
most
common
worldwide,
with
over
one
million
new
cases
reported
between
2015
and
2018.
Resistant
starch
found
in
Kepok
Banana
extract
may
have
potential
colon
prevention.
Additionally,
diets
rich
iron
vitamin
C
contribute
to
chronic
disease
Moringa
leaves,
C,
enhance
absorption.
This
study
evaluated
growth
of
Lactobacillus
Shigella
spp
female
rats
given
Moringa-Banana
(MBS)
a
prebiotic
supplement.
Results
showed
significant
differences
gut
microbiota
MBS
consumption,
higher
concentrations
beneficial
bacteria
reduced
levels
pathogenic
observed
group
receiving
highest
dose.
These
findings
suggest
that
could
be
candidate
for
further
development.
Fermentation,
Год журнала:
2025,
Номер
11(4), С. 231 - 231
Опубликована: Апрель 21, 2025
Introduction:
Non-communicable
chronic
diseases,
such
as
overweight
and
obesity,
are
considered
a
high
risk
for
type
2
diabetes.
Globally,
there
536.6
million
people
with
Mexico
has
prevalence
of
these
diseases.
Objective:
The
objective
this
study
was
to
evaluate
the
effects
synbiotic
beverage
12-week
dietary
intervention
on
body
composition
biochemical
parameters
in
women
T2D,
overweight,
or
obesity
an
additional
strategy
treatment.
Methods:
This
double-blind,
randomized,
experimental
fermented
n
=
51
divided
into
four
groups:
G1
followed
moderate
calorie-restricted
diet,
G2
same
diet
consumed
beverage,
G3
only
G4
placebo
beverage.
Results:
Significant
changes
were
seen
BMI
(p
<
0.001)
fat
mass
(kg)
(%)
after
intervention,
proving
that
had
effect
composition.
Conclusions:
decreases
different
profiles
seen,
showing
benefits
A
consumption
could
be
treatment
non-communicable
