Science China Life Sciences, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 28, 2024
Язык: Английский
Virulence, Год журнала: 2024, Номер 15(1)
Опубликована: Авг. 27, 2024
Metabolic disease is a worldwide epidemic that has become public health problem. Gut microbiota considered to be one of the important factors maintain human by regulating host metabolism. As an abundant bacterium in gut,
Язык: Английский
Процитировано
13
Frontiers in Microbiology, Год журнала: 2024, Номер 15
Опубликована: Март 27, 2024
Background The correlation between diabetic nephropathy (DN) and gut microbiota (GM) has been suggested in numerous animal experiments cross-sectional studies. However, a causal association GM DN not ascertained. Methods This research adopted MR analysis to evaluate the link derived from data acquired through publicly available genome-wide studies (GWAS). study utilized inverse variance weighted (IVW) approach assess DN. Four additional methods including MR-Egger, median, mode, simple mode were employed ensure comprehensive robust results. Cochran’s Q test MR-Egger method conducted identify heterogeneity horizontal pleiotropy, respectively. leave-one-out was stability of Finally, reverse performed Results According IVW analysis, Class Verrucomicrobiae ( p = 0.003), Order Verrucomicrobiales Family Verrucomicrobiaceae Genus Akkermansia Catenibacterium 0.031), Coprococcus 1 0.022), Eubacterium hallii group 0.018), Marvinbryantia 0.023) associated with higher risk On contrary, Actinobacteria 0.037), Group ventriosum 0.030), Ruminococcus gauvreauii 0.048), Lactobacillales 0.045), Phylum Proteobacteria 0.017) lower sensitivity did any substantial pleiotropy or outcomes. We found effects on 11 species analysis. Notably, are mutually causalities. Conclusion identified which may enhance understanding intestinal-renal axis provide novel potential targets for early non-invasive diagnosis treatment
Язык: Английский
Процитировано
4
Frontiers in Medicine, Год журнала: 2025, Номер 12
Опубликована: Фев. 3, 2025
Background Akkermansia muciniphila , as a probiotic, is negatively linked to IBD, obesity, and T2DM. The aim of this study was comprehensively assess the research status over past decade explore relationships between bacterium various health-related aspects. Methods Tools VOSviewer, Bibliometrix, CiteSpace were used analyze aspects including publication metrics, contributors, institutions, geography, journals, funding, keywords. Results Over decade, on has demonstrated consistent annual growth in number publications, with notable peak 2021. China led totaling 151, whereas United States exhibited higher centrality value. Among 820 institutions involved research, University California (from States) Chinese Academy Sciences China) occupied central positions. Willem M. De Vos ranked at top, 12 publications 1,108 citations. journal GUT, which had 5,125 citations an Impact Factor 23.0 2024, most highly cited. cited articles deepened understanding bacterium’s impact human health, spanning from basic translational medicine. Thirty-nine high-frequency keywords grouped into five clusters, illustrating ’s associations metabolic diseases, chronic kidney disease, gut-brain axis, intestinal inflammation, Bacteroidetes-Firmicutes shifts. Conclusion Given anti-inflammatory gut-barrier-strengthening properties, it holds promise therapeutic for disorders, inflammatory conditions. Therefore, future should its potential further by conducting clinical trials, elucidating mechanisms action, investigating efficacy safety diverse patient populations.
Язык: Английский
Процитировано
0
Microbial Cell Factories, Год журнала: 2025, Номер 24(1)
Опубликована: Фев. 21, 2025
Clostridium perfringens (C. perfringens) is an important zoonotic pathogen. The diseases such as necrotic enteritis (NE), enterotoxemia, gas gangrene and food poisoning caused by its infection seriously threaten the lives of both humans animals. However, under severe situation antibiotic resistance, development new antibacterial strategies or drugs deserves great attention. In this study, we selected virulence factor Type IV pili (TFP) C. target for drug screening. gliding motility, biofilm formation, cell adhesion activity natural compound isoxanthohumol (IXN) against were determined. Transmission electron microscopy (TEM), TFP gene transcription analysis Western blot used to detect expression PilA pilin. therapeutic effect IXN on was demonstrated through a mouse model. It confirmed that inhibits function down-regulating TFP-encoding genes two-component regulatory genes. conclusion, our study shows has potential inhibit in anti-infection applications.
Язык: Английский
Процитировано
0
Archives of Microbiology, Год журнала: 2025, Номер 207(4)
Опубликована: Март 4, 2025
Язык: Английский
Процитировано
0
Antioxidants, Год журнала: 2025, Номер 14(4), С. 378 - 378
Опубликована: Март 22, 2025
As a prevalent metabolic disorder, the increasing incidence of diabetes imposes significant burden on global healthcare. Flavonoids in natural phytochemical products exhibit notable hypoglycemic properties, making them potential alternatives for treatment. This article summarizes properties flavonoid subcategories studied recent years, including flavones, isoflavones, flavonols, flavanols, and others. The relevant targets signal pathways, such as α-amylase, α-glucosidase, insulin receptor substrate (IRS)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT), PKR-like endoplasmic reticulum (PERK)/eukaryotic initiation factor 2α (eIF2α)/activation transcription 4 (ATF4)/C/EBP homologous protein (CHOP), etc., are also elaborated. Additionally, flavonoids have been demonstrated to modulate gut microbiota its metabolites. Through aforementioned mechanisms, mainly suppress carbohydrate metabolism gluconeogenesis; facilitate glucose uptake, glycogenesis, secretion; mitigate resistance, oxidative stress, inflammation, etc. Notably, several studies indicated that certain displayed synergistic effects. In conclusion, this provides comprehensive review effects investigated aiming offer theoretical insights their further exploration.
Язык: Английский
Процитировано
0
Current Research in Food Science, Год журнала: 2025, Номер unknown, С. 101039 - 101039
Опубликована: Март 1, 2025
Non-alcoholic steatohepatitis (NASH), characterized by severe fatty liver-associated inflammation and hepatocellular damage, is a major precursor to cirrhosis carcinoma. While the exact pathogenesis of NASH remains unclear, gut microbiota dysbiosis has been implicated as key factor contributing endotoxin translocation chronic liver inflammation. Recent studies have highlighted therapeutic potential bovine colostrum-derived extracellular vesicles (BCEVs) in modulating enhancing barrier function, but their effects on remain largely unexplored. To investigate protective BCEVs against NASH, 8-wk-old mice were fed NASH-inducing diet for 3 wks while concurrently receiving oral BCEV administration. treatment markedly ameliorated hepatic steatosis, fibrosis, Transcriptomic analyses demonstrated notable reduction lipid metabolism, bacterial response, inflammatory pathways intestine, well reduced expression inflammation- fibrosis-related liver. Gut profiling revealed an increased abundance Akkermansia, accompanied enhanced cholesterol excretion. Furthermore, promoted production tight junction proteins mucin gut, reinforcing intestinal integrity. These findings suggest that promote proliferation which turn prevents This leakage alleviates fibrosis. Overall, this study highlights novel strategy managing targeting gut-liver axis through modulation function.
Язык: Английский
Процитировано
0
Inflammopharmacology, Год журнала: 2024, Номер 32(3), С. 1983 - 1998
Опубликована: Апрель 20, 2024
Язык: Английский
Процитировано
3
Nutrients, Год журнала: 2024, Номер 16(14), С. 2270 - 2270
Опубликована: Июль 14, 2024
(1) Background: Proglucagon-derived peptides (PDGPs) including glucagon (Gcg), GLP-1, and GLP-2 regulate lipid metabolism in the liver, adipocytes, intestine. However, mechanism by which PGDPs participate alterations induced high-fat diet (HFD) feeding has not been elucidated. (2) Methods: Mice deficient PGDP (GCGKO) control mice were fed HFD for 7 days analyzed, differences adipose tissue, duodenum investigated. (3) Results: GCGKO under showed lower expression levels of genes involved free fatty acid (FFA) oxidation such as Hsl, Atgl, Cpt1a, Acox1 (p < 0.05), Pparα = 0.05) mRNA liver than mice, both FFA triglycerides content tissue weight mice. On other hand, phosphorylation hormone-sensitive lipase (HSL) white did differ between two groups. exhibited Cd36 well increased fecal cholesterol contents compared to HFD-controls. (4) Conclusions: exhibit a lesser increase hepatic triglyceride weight, despite reduced β-oxidation Thus, absence prevents dietary-induced development due decreased uptake intestinal tract.
Язык: Английский
Процитировано
2
Journal of Gastroenterology and Hepatology, Год журнала: 2024, Номер unknown
Опубликована: Окт. 13, 2024
Abstract Insulin resistance (IR) is a pathogenic factor in numerous metabolic diseases. The gut microbiota plays crucial role maintaining the function of intestinal barrier and overall human health, thereby influencing IR. Dysbiosis can contribute to development Therefore, it essential maintain balanced diverse for optimal health. Akkermansia muciniphila , widely present microorganism intestine, has been shown regulate gastrointestinal mucosal integrity, reduce endotoxin penetration, decrease systemic inflammation levels, improve insulin sensitivity. Reduced abundance A. associated with an increased risk IR other diseases, highlighting its correlation Understanding regulatory mechanism comprehending pathogenesis developing novel strategies preventing treating related disorders. Individual variations may exist both composition impact on among different individuals. Further investigation into individual differences between will facilitate advancements personalized medicine by promoting tailored interventions based composition, which potential future direction that would optimize sensitivity while disease occurrence. In this review, we describe physiological characteristics emphasize roles underlying mechanisms contributing pathology, summarize how alterations affect development, providing valuable insights further research as well new drug targeting diabetes.
Язык: Английский
Процитировано
2