Recent Expansions in the Potential of Uracil Derivatives as Chemotherapeutic, Antimicrobial, and Antiviral Agents: A Review
ChemistrySelect,
Год журнала:
2025,
Номер
10(10)
Опубликована: Март 1, 2025
Abstract
Uracil
is
a
privileged
scaffold
in
medicinal
chemistry,
playing
crucial
role
the
development
of
therapeutic
agents.
Clinically
used
uracil
analogs,
such
as
5‐fluorouracil,
tegafur,
carmofur,
and
floxuridine,
have
shown
significant
anticancer
potential.
However,
their
clinical
applications
are
limited
by
poor
selectivity,
central
nervous
system
toxicity,
gastrointestinal
side
effects.
To
overcome
these
challenges,
structural
modifications
hybridization
with
other
pharmacophores
been
explored,
enhancing
efficacy
selectivity.
This
review
highlights
recent
advancements
(post‐2013)
chemistry
biological
activity
derivatives,
categorizing
them
into
5‐halo‐uracils,
substituted
uracils,
nucleosides,
uracil‐based
hybrids,
organometallic
thiouracils,
prodrugs,
fused
uracils.
Their
primarily
linked
to
DNA
biosynthesis
inhibition
cell
cycle
arrest,
while
antiviral
antimicrobial
effects
arise
from
disrupting
key
steps
viral
replication
bacterial
growth.
Promising
results
observed
against
HIV,
HCMV,
herpes
viruses,
Staphylococcus
aureus
,
Escherichia
coli
Bacillus
cereus
Pseudomonas
aeruginosa
Trypanosoma
Leishmania
species.
aims
inspire
chemists
develop
highly
selective,
less
toxic,
more
potent
chemotherapeutic,
antiviral,
agents
for
future
applications.
Язык: Английский
Preparation of a new reusable magnetic organocatalyst to synthesis of polyhydroquinoline derivatives as cytotoxic Agents: Synthesis and biological evaluation
Journal of Saudi Chemical Society,
Год журнала:
2024,
Номер
28(6), С. 101922 - 101922
Опубликована: Авг. 30, 2024
Язык: Английский
Azole Derivatives: Cutting‐Edge Agents in Cancer Therapy
ChemistrySelect,
Год журнала:
2024,
Номер
9(43)
Опубликована: Ноя. 1, 2024
Abstract
Monocyclic
5‐membered
heterocycles
including
imidazoles,
thiazoles,
oxazoles,
and
their
related
compounds
have
gained
significant
attention
in
medicinal
chemistry
because
of
potent
anticancerous
activity.
These
small
heterocyclic
molecules
possess
versatile
properties,
biological
activity,
absorption,
distribution,
metabolism,
excretion,
chemical
diversity
that
give
them
immense
potential
as
anticancer
agents.
It
is
also
a
fact
inherent
characteristic
azoles
to
combine
with
many
through
hydrogen
bond,
stacking,
hydrophobic
interaction
makes
effective
against
almost
all
cancer
types.
In
the
present
paper
author
discusses
way
which
connected
structure
monocyclic
activity
namely
ability
these
intercalate
DNA,
inhibit
some
enzymes
interfere
cellular
signaling
pathways.
Interestingly,
several
azole
derivatives
been
seen
be
preclinical
efficacy
studies
well
clinical
trials
are
considered
overcoming
problem
resistance
side
effects
common
As
synthetic
progresses,
structural
system
has
diversified
development
pharmacology
become
more
specific.
This
helped
enhancing
formation
new
class
improved
selectivity
efficacy.
Furthermore,
comprehensive
review
explains
how
computational
structure‐activity
relationship
(SAR)
approaches
applied
design
future‐generation
compounds.
light
facts,
this
article
designed
broad
overview
current
state
azole‐based
agents
an
attempt
further
assert
its
therapeutic
promise
spur
attempts
at
infusing
said
into
therapeutics
fray.
The
discoveries
made
study
may
allow
radical
different
approaches,
could
lead
targeted
treatment
cancer.
Язык: Английский
Binding interaction of sodium benzoate, potassium sorbate and sodium dihydrogen citrate with BSA as food preservatives: in Vitro analysis and computational studies
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Ноя. 25, 2024
Advanced
glycation
end
products
(AGEs)
are
obtained
intermediate
from
nonenzymatic
reactions
between
reducing
sugars
and
proteins,
lipids,
or
nucleic
acids
it's
associated
with
diabetic
complications.
Today,
potassium
sorbate
(PS),
sodium
citrate
(CIT)
benzoate
(SB)
were
widespread
used
as
food
preservatives
that
can
easily
enter
biological
matrices.
Here,
the
interaction
glycosylation
Bovine
Serum
Albumin
(BSA)
individually
combination
of
two
three
was
studied
by
biochemical
simulation
analysis.
The
results
revealed
an
increase
in
absorption
fluorescent
intensity
all
treated
groups.
most
carbonyl
glycosylated
compounds
observed
treatment
PS
its
combined
groups
preservatives.
Treatment
alone
caused
a
significant
red
blood
cell
hemolysis
MDA
level
(p
<
0.05).
vitro
experiments
line
docking
studies
albumin
important
subdomain
BSA
show
stability
BSA-ligand
complex.
Simultaneous
cause
their
synergistic
effect
possible
harm
to
body.
In
addition,
molecular
experiment
suggests
Sodium
Benzoate,
Potassium
Sorbate
Dihydrogen
Citrate
interact
BSA.
Язык: Английский