Binding interaction of sodium benzoate, potassium sorbate and sodium dihydrogen citrate with BSA as food preservatives: in Vitro analysis and computational studies DOI Creative Commons
Leila Emami,

Elaheh Khodarahimi,

Pegah Mardaneh

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 25, 2024

Advanced glycation end products (AGEs) are obtained intermediate from nonenzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids it's associated with diabetic complications. Today, potassium sorbate (PS), sodium citrate (CIT) benzoate (SB) were widespread used as food preservatives that can easily enter biological matrices. Here, the interaction glycosylation Bovine Serum Albumin (BSA) individually combination of two three was studied by biochemical simulation analysis. The results revealed an increase in absorption fluorescent intensity all treated groups. most carbonyl glycosylated compounds observed treatment PS its combined groups preservatives. Treatment alone caused a significant red blood cell hemolysis MDA level (p < 0.05). vitro experiments line docking studies albumin important subdomain BSA show stability BSA-ligand complex. Simultaneous cause their synergistic effect possible harm to body. In addition, molecular experiment suggests Sodium Benzoate, Potassium Sorbate Dihydrogen Citrate interact BSA.

Language: Английский

Recent Expansions in the Potential of Uracil Derivatives as Chemotherapeutic, Antimicrobial, and Antiviral Agents: A Review DOI Open Access
Ramandeep Kaur, Tanaya Roychowdhury, Nihar Kinarivala

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(10)

Published: March 1, 2025

Abstract Uracil is a privileged scaffold in medicinal chemistry, playing crucial role the development of therapeutic agents. Clinically used uracil analogs, such as 5‐fluorouracil, tegafur, carmofur, and floxuridine, have shown significant anticancer potential. However, their clinical applications are limited by poor selectivity, central nervous system toxicity, gastrointestinal side effects. To overcome these challenges, structural modifications hybridization with other pharmacophores been explored, enhancing efficacy selectivity. This review highlights recent advancements (post‐2013) chemistry biological activity derivatives, categorizing them into 5‐halo‐uracils, substituted uracils, nucleosides, uracil‐based hybrids, organometallic thiouracils, prodrugs, fused uracils. Their primarily linked to DNA biosynthesis inhibition cell cycle arrest, while antiviral antimicrobial effects arise from disrupting key steps viral replication bacterial growth. Promising results observed against HIV, HCMV, herpes viruses, Staphylococcus aureus , Escherichia coli Bacillus cereus Pseudomonas aeruginosa Trypanosoma Leishmania species. aims inspire chemists develop highly selective, less toxic, more potent chemotherapeutic, antiviral, agents for future applications.

Language: Английский

Citations

1
Preparation of a new reusable magnetic organocatalyst to synthesis of polyhydroquinoline derivatives as cytotoxic Agents: Synthesis and biological evaluation DOI Creative Commons
Leila Amiri‐Zirtol,

Ali Yargholi,

Leila Emami

et al.

Journal of Saudi Chemical Society, Journal Year: 2024, Volume and Issue: 28(6), P. 101922 - 101922

Published: Aug. 30, 2024

Language: Английский

Citations

4
Azole Derivatives: Cutting‐Edge Agents in Cancer Therapy DOI

Anuradha Mehra,

Amit Mittal, Rekha Sangwan

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(43)

Published: Nov. 1, 2024

Abstract Monocyclic 5‐membered heterocycles including imidazoles, thiazoles, oxazoles, and their related compounds have gained significant attention in medicinal chemistry because of potent anticancerous activity. These small heterocyclic molecules possess versatile properties, biological activity, absorption, distribution, metabolism, excretion, chemical diversity that give them immense potential as anticancer agents. It is also a fact inherent characteristic azoles to combine with many through hydrogen bond, stacking, hydrophobic interaction makes effective against almost all cancer types. In the present paper author discusses way which connected structure monocyclic activity namely ability these intercalate DNA, inhibit some enzymes interfere cellular signaling pathways. Interestingly, several azole derivatives been seen be preclinical efficacy studies well clinical trials are considered overcoming problem resistance side effects common As synthetic progresses, structural system has diversified development pharmacology become more specific. This helped enhancing formation new class improved selectivity efficacy. Furthermore, comprehensive review explains how computational structure‐activity relationship (SAR) approaches applied design future‐generation compounds. light facts, this article designed broad overview current state azole‐based agents an attempt further assert its therapeutic promise spur attempts at infusing said into therapeutics fray. The discoveries made study may allow radical different approaches, could lead targeted treatment cancer.

Language: Английский

Citations

0
Binding interaction of sodium benzoate, potassium sorbate and sodium dihydrogen citrate with BSA as food preservatives: in Vitro analysis and computational studies DOI Creative Commons
Leila Emami,

Elaheh Khodarahimi,

Pegah Mardaneh

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 25, 2024

Advanced glycation end products (AGEs) are obtained intermediate from nonenzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids it's associated with diabetic complications. Today, potassium sorbate (PS), sodium citrate (CIT) benzoate (SB) were widespread used as food preservatives that can easily enter biological matrices. Here, the interaction glycosylation Bovine Serum Albumin (BSA) individually combination of two three was studied by biochemical simulation analysis. The results revealed an increase in absorption fluorescent intensity all treated groups. most carbonyl glycosylated compounds observed treatment PS its combined groups preservatives. Treatment alone caused a significant red blood cell hemolysis MDA level (p < 0.05). vitro experiments line docking studies albumin important subdomain BSA show stability BSA-ligand complex. Simultaneous cause their synergistic effect possible harm to body. In addition, molecular experiment suggests Sodium Benzoate, Potassium Sorbate Dihydrogen Citrate interact BSA.

Language: Английский

Citations

0