Synthesis, characterization, biological activity, DFT, molecular docking and ADME studies of metal (II) complexes of a bidentate Schiff’s base (E)-4-chloro-2-((2-hydroxy-3-methoxybenzylidene)amino)benzoic acid

Journal of Dispersion Science and Technology, Год журнала: 2025, Номер unknown, С. 1 - 14

Опубликована: Фев. 11, 2025

Язык: Английский

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Synergistic Exploration of Thiazole Derivatives: Synthesis, Antimicrobial Activity and Computational Insights

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141772 - 141772

Опубликована: Фев. 1, 2025

Язык: Английский

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Comprehensive Analysis of Hydrazone Schiff Bases: Synthesis, Structural Characterization, DFT Studies, Molecular Docking Insights and Bioactivity Assessment

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141905 - 141905

Опубликована: Март 1, 2025

Язык: Английский

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Synthesis, antioxidant activity, DFT simulations, molecular docking studies of Schiff base derivatives containing 2-(2-hydrazinyl) thiazole moiety

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 142150 - 142150

Опубликована: Март 1, 2025

Язык: Английский

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Recent advances in Schiff bases and Cu(II) complexes: Applications in fluorescence imaging and anticancer therapy (2020–2024)

Journal of Inorganic Biochemistry, Год журнала: 2025, Номер 268, С. 112909 - 112909

Опубликована: Апрель 5, 2025

Язык: Английский

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Crystal Structure of 4-(4-Fluorophenyl)-1,3-thiazole-2-amine in dimeric form: Green synthesis, DFT, HS analysis, Anticandidal and Anticancer study.

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 142483 - 142483

Опубликована: Апрель 1, 2025

Язык: Английский

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Structure Elucidation and Computational Studies of the Thiazole Derivative Against SARS-CoV-2 Virus: Insights from XRD, DFT, Molecular Docking, and Molecular Dynamics Simulation

Journal of Molecular Structure, Год журнала: 2024, Номер 1322, С. 140550 - 140550

Опубликована: Окт. 31, 2024

Язык: Английский

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DNA and bovine serum albumin protein (BSA) interaction of antitumor supramolecular nickel(II) complex: Inference for drug design

Journal of Industrial and Engineering Chemistry, Год журнала: 2024, Номер 140, С. 225 - 236

Опубликована: Май 21, 2024

Язык: Английский

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Microwave‐Assisted Synthesis of Novel Co(II), Cu(II), and Zn(II) Complexes Derived From Fluorinated Thiazole Schiff Bases: Antimicrobial, Anticancer, and Molecular Docking Study

Applied Organometallic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 21, 2024

ABSTRACT Six new complexes of Co(II), Cu(II), and Zn(II) metal were synthesized by microwave‐assisted green method from fluorinated Schiff base ligands. The ligands prepared the condensation reaction 4‐(p‐fluorophenyl)‐5‐methyl‐2‐aminothiazole with 4‐methylsalicyldehyde (L1H) 4‐methoxysalicyldehyde (L2H). FT‐IR, NMR, HR‐MS spectral data confirm tridentate nature in Co(II) bidentate Cu(II) complexes. elemental analysis TGA study revealed 1:2 (M:L) stoichiometry all Electronic absorption, magnetic susceptibility, XRD express geometry crystal systems antimicrobial anticancer their achieved. results indicate that L2H have greater potency against Gram‐positive bacteria. In contrast, L1H exhibited zone inhibition Gram‐negative fungal strains. Furthermore, among complexes, complex ligand was found to exhibit potent activity IC 50 values 16.18 11.10 μM MDA‐MB‐231 A549 cell lines compared other parent Molecular docking EGFR (PDB: 5XGM) shows strong binding interactions good free energy support experimental results.

Язык: Английский

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Novel Co(Ii), Cu(Ii) and Zn(Ii) Complexes Derived from Schiff Base Ligands Containing 4,5-Disubstituted Thiazole: Green Synthesis, Antimicrobial, Anti-Cancer and Molecular Docking Study

Опубликована: Янв. 1, 2024

Язык: Английский

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