The Neuroradiology Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 4, 2024
Background:
Multiple
sclerosis
(MS)
is
a
long-term
autoimmune
inflammatory
disorder
that
affects
the
central
nervous
system
leading
to
neurodegeneration,
and
can
involve
variety
of
symptoms.
These
symptoms
include
fatigue,
anxiety,
depression,
cognitive
decline,
which
may
be
silent.
The
objective
this
study
was
explore
changes
in
brain
iron
deposition
people
with
relapsing-remitting
MS
(pw-RRMS)
compared
healthy
controls
(HCs),
particular
focus
on
regions
fear
circuit.
Additionally,
aimed
evaluate
relationship
between
these
areas
clinical
measurements.
Methods:
Pw-RRMS
HCs
participants
underwent
MRI
scans
using
quantitative
susceptibility
mapping
(QSM)
assess
circuit
two
groups.
analyzed
correlations
Results:
We
recruited
35
pw-RRMS
(mean
age
=
46.7
±
11
years;
median
EDSS
2.5)
18
40.6
17.8
years).
Our
research
revealed
significant
increases
QSM
signals
relating
HCs,
whole
(β
5.82,
p
<
0.001),
caudate
21.48,
putamen
17.53,
0.03),
showing
greatest
difference.
particularly
are
strongly
associated
fatigue
pw-RRMS.
values
anterior
cingulate
cortex
significantly
differed
normal
abnormal
depression
scores
(
0.007).
Conclusions:
results
strengthen
increased
specific
silent
However,
further
studies
required
confirm
findings
clarify
implications
accumulation
pathophysiology.
Signal Transduction and Targeted Therapy,
Год журнала:
2025,
Номер
10(1)
Опубликована: Янв. 2, 2025
Abstract
Rampant
phospholipid
peroxidation
initiated
by
iron
causes
ferroptosis
unless
this
is
restrained
cellular
defences.
Ferroptosis
increasingly
implicated
in
a
host
of
diseases,
and
unlike
other
cell
death
programs
the
physiological
initiation
conceived
to
occur
not
an
endogenous
executioner,
but
withdrawal
guardians
that
otherwise
constantly
oppose
induction.
Here,
we
profile
key
ferroptotic
defence
strategies
including
regulation,
modulation
enzymes
metabolite
systems:
glutathione
reductase
(GR),
suppressor
protein
1
(FSP1),
NAD(P)H
Quinone
Dehydrogenase
(NQO1),
Dihydrofolate
(DHFR),
retinal
reductases
dehydrogenases
(RDH)
thioredoxin
(TR).
A
common
thread
uniting
all
metabolites
combat
lipid
during
dependence
on
reductant,
nicotinamide
adenine
dinucleotide
phosphate
(NADPH).
We
will
outline
how
cells
control
central
carbon
metabolism
produce
NADPH
necessary
precursors
defend
against
ferroptosis.
Subsequently
discuss
evidence
for
dysregulation
different
disease
contexts
glucose-6-phosphate
dehydrogenase
deficiency,
cancer
neurodegeneration.
Finally,
several
anti-ferroptosis
therapeutic
spanning
use
radical
trapping
agents,
dependent
redox
support
highlight
current
landscape
clinical
trials
focusing
Expert Review of Neurotherapeutics,
Год журнала:
2024,
Номер
24(2), С. 201 - 216
Опубликована: Янв. 18, 2024
Introduction
While
magnetic
resonance
imaging
(MRI)
is
established
in
diagnosing
and
monitoring
disease
activity
multiple
sclerosis
(MS),
its
utility
predicting
progression
less
clear.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(3), С. 1365 - 1365
Опубликована: Янв. 23, 2024
In
multiple
sclerosis
(MS),
there
is
a
great
need
for
treatment
with
the
ability
to
suppress
compartmentalized
inflammation
within
central
nervous
system
(CNS)
and
promote
remyelination
regeneration.
Mesenchymal
stem
cells
(MSCs)
represent
promising
therapeutic
option,
as
they
have
been
shown
migrate
site
of
CNS
injury
exert
neuroprotective
properties,
including
immunomodulation,
neurotrophic
factor
secretion,
endogenous
neural
cell
stimulation.
This
review
summarizes
current
understanding
underlying
mechanisms
discusses
translation
MSC
transplantation
their
derivatives
from
pre-clinical
demyelinating
models
clinical
trials
MS
patients.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Март 21, 2024
Background
Multiple
sclerosis
(MS)
is
the
most
common
chronic
inflammatory
disease
of
central
nervous
system.
Currently,
pathological
mechanisms
MS
are
not
fully
understood,
but
research
has
suggested
that
iron
metabolism
disorder
may
be
associated
with
onset
and
clinical
manifestations
MS.
Methods
materials
The
study
utilized
publicly
available
databases
bioinformatics
techniques
for
gene
expression
data
analysis,
including
differential
weighted
correlation
network
enrichment
construction
logistic
regression
models.
Subsequently,
Mendelian
randomization
was
used
to
assess
causal
relationship
between
different
markers
Results
This
identified
IREB2,
LAMP2,
ISCU,
ATP6V1G1,
ATP13A2,
SKP1
as
genes
multiple
metabolism,
establishing
their
multi-gene
diagnostic
value
an
AUC
0.83.
Additionally,
analysis
revealed
a
potential
transferrin
saturation
(p=2.22E-02;
OR
95%CI=0.86
(0.75,
0.98)),
well
serum
(p=2.18E-04;
95%CI=1.22
(1.10,
1.36)).
Conclusion
comprehensively
explored
through
integrated
methods.
findings
provide
important
insights
further
into
role
in
pathogenesis
offer
crucial
theoretical
support
treatment
Brain,
Год журнала:
2024,
Номер
147(11), С. 3665 - 3680
Опубликована: Июль 22, 2024
Abstract
The
interaction
between
ageing
and
multiple
sclerosis
is
complex
carries
significant
implications
for
patient
care.
Managing
effectively
requires
an
understanding
of
how
impact
brain
structure
function.
Ageing
inherently
induces
changes,
including
reduced
plasticity,
diminished
grey
matter
volume,
ischaemic
lesion
accumulation.
When
combined
with
pathology,
these
age-related
alterations
may
worsen
clinical
disability.
also
influence
the
response
patients
to
therapies
and/or
their
side
effects,
highlighting
importance
adjusted
treatment
considerations.
MRI
highly
sensitive
age-
sclerosis-related
processes.
Accordingly,
can
provide
insights
into
relationship
sclerosis,
enabling
a
better
pathophysiological
interplay
informing
selection.
This
review
summarizes
current
knowledge
on
immunopathological
aspects
in
CNS
context
sclerosis.
Starting
from
immunosenescence,
ageing-related
pathological
mechanisms
specific
features
like
enlarged
Virchow-Robin
spaces,
this
then
explores
aspects,
late-onset
age
diagnostic
criteria,
comorbidity
effects
imaging
features.
role
neurodegeneration,
iron
dynamics
myelin
changes
influenced
by
contribute
defining
patients,
are
discussed.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(7), С. 2003 - 2003
Опубликована: Март 29, 2024
Multiple
sclerosis
(MS)
is
the
most
common
cause
of
non-traumatic
long-term
disability
in
young
adults.
Whole-body
cryostimulation
(WBC)
a
cold-based
physical
therapy
known
to
induce
physiological
exercise-mimicking
changes
cardiovascular,
neuromuscular,
immune,
and
endocrine
systems
influence
functional
psychological
parameters
by
exposing
human
body
cryogenic
temperatures
(≤−110
°C)
for
2–3
min.
The
purpose
this
scoping
review
present
an
overall
view
on
potential
role
WBC
as
adjuvant
treatment
MS.
PubMed,
ScienceDirect,
Embase,
Web
Science
were
searched
up
30
November
2023,
total
13
articles
included.
may
have
beneficial
antioxidant
effects
short-term
There
no
significant
enzymes,
nitric
oxide
levels,
metalloproteinase
blood
counts,
rheology,
biochemistry.
can
lead
reduction
fatigue
improvement
status,
with
effect
both
mental
well-being.
reported
adverse
effects.
results
suggest
that
complement
therapeutic
options
patients
MS,
cold
stimulation
been
shown
activate
processes
improve
mood,
anxiety,
fatigue.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(13), С. 7027 - 7027
Опубликована: Июнь 27, 2024
There
is
growing
evidence
that
inflammation
impairs
erythrocyte
structure
and
function.
We
assessed
the
impact
of
mild
systemic
on
fragility
in
three
different
settings.
In
order
to
investigate
causation,
osmotic
was
measured
mice
challenged
with
a
live
attenuated
bacterial
strain
induce
low-grade
inflammation;
significant
increase
observed.
To
gather
associated
humans,
two
observational
studies
were
conducted.
First,
using
retrospective
study
design,
relationship
between
reticulocyte-based
surrogate
markers
haemolysis
high-sensitivity
C-reactive
protein
investigated
9292
healthy
participants
UK
Biobank
project.
Secondly,
we
prospectively
(measured
by
urinary
neopterin/creatinine
ratio)
mixed
population
(n
=
54)
volunteers
individuals
long-term
medical
conditions.
Both
human
keeping
fragility.
Taken
together,
conclude
increases
may
contribute
haemolysis.
Further
research
needed
assess
molecular
underpinnings
this
pathway
clinical
implications
inflammatory
