Quantitative susceptibility mapping of the fear circuit: Associations with silent symptoms in relapsing-remitting multiple sclerosis DOI
Ibrahim Khormi, Amir Fazlollahi, Oun Al‐iedani

et al.

The Neuroradiology Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Background: Multiple sclerosis (MS) is a long-term autoimmune inflammatory disorder that affects the central nervous system leading to neurodegeneration, and can involve variety of symptoms. These symptoms include fatigue, anxiety, depression, cognitive decline, which may be silent. The objective this study was explore changes in brain iron deposition people with relapsing-remitting MS (pw-RRMS) compared healthy controls (HCs), particular focus on regions fear circuit. Additionally, aimed evaluate relationship between these areas clinical measurements. Methods: Pw-RRMS HCs participants underwent MRI scans using quantitative susceptibility mapping (QSM) assess circuit two groups. analyzed correlations Results: We recruited 35 pw-RRMS (mean age = 46.7 ± 11 years; median EDSS 2.5) 18 40.6 17.8 years). Our research revealed significant increases QSM signals relating HCs, whole (β 5.82, p < 0.001), caudate 21.48, putamen 17.53, 0.03), showing greatest difference. particularly are strongly associated fatigue pw-RRMS. values anterior cingulate cortex significantly differed normal abnormal depression scores ( 0.007). Conclusions: results strengthen increased specific silent However, further studies required confirm findings clarify implications accumulation pathophysiology.

Language: Английский

In defence of ferroptosis DOI Creative Commons
Francesca M. Alves, Darius J.R. Lane,

Triet Phu Minh Nguyen

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Jan. 2, 2025

Abstract Rampant phospholipid peroxidation initiated by iron causes ferroptosis unless this is restrained cellular defences. Ferroptosis increasingly implicated in a host of diseases, and unlike other cell death programs the physiological initiation conceived to occur not an endogenous executioner, but withdrawal guardians that otherwise constantly oppose induction. Here, we profile key ferroptotic defence strategies including regulation, modulation enzymes metabolite systems: glutathione reductase (GR), suppressor protein 1 (FSP1), NAD(P)H Quinone Dehydrogenase (NQO1), Dihydrofolate (DHFR), retinal reductases dehydrogenases (RDH) thioredoxin (TR). A common thread uniting all metabolites combat lipid during dependence on reductant, nicotinamide adenine dinucleotide phosphate (NADPH). We will outline how cells control central carbon metabolism produce NADPH necessary precursors defend against ferroptosis. Subsequently discuss evidence for dysregulation different disease contexts glucose-6-phosphate dehydrogenase deficiency, cancer neurodegeneration. Finally, several anti-ferroptosis therapeutic spanning use radical trapping agents, dependent redox support highlight current landscape clinical trials focusing

Language: Английский

Citations

3
An update on the role of magnetic resonance imaging in predicting and monitoring multiple sclerosis progression DOI Creative Commons
Piriyankan Ananthavarathan, Nitin Sahi, Declan Chard

et al.

Expert Review of Neurotherapeutics, Journal Year: 2024, Volume and Issue: 24(2), P. 201 - 216

Published: Jan. 18, 2024

Introduction While magnetic resonance imaging (MRI) is established in diagnosing and monitoring disease activity multiple sclerosis (MS), its utility predicting progression less clear.

Language: Английский

Citations

11
The Therapeutic Mechanisms of Mesenchymal Stem Cells in MS—A Review Focusing on Neuroprotective Properties DOI Open Access
Sonia Gavasso, Torbjørn Kråkenes,

Håkon Olsen

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1365 - 1365

Published: Jan. 23, 2024

In multiple sclerosis (MS), there is a great need for treatment with the ability to suppress compartmentalized inflammation within central nervous system (CNS) and promote remyelination regeneration. Mesenchymal stem cells (MSCs) represent promising therapeutic option, as they have been shown migrate site of CNS injury exert neuroprotective properties, including immunomodulation, neurotrophic factor secretion, endogenous neural cell stimulation. This review summarizes current understanding underlying mechanisms discusses translation MSC transplantation their derivatives from pre-clinical demyelinating models clinical trials MS patients.

Language: Английский

Citations

11
Iron metabolism disorder and multiple sclerosis: a comprehensive analysis DOI Creative Commons
Chao Tang, Jiaxin Yang,

Chaomin Zhu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 21, 2024

Background Multiple sclerosis (MS) is the most common chronic inflammatory disease of central nervous system. Currently, pathological mechanisms MS are not fully understood, but research has suggested that iron metabolism disorder may be associated with onset and clinical manifestations MS. Methods materials The study utilized publicly available databases bioinformatics techniques for gene expression data analysis, including differential weighted correlation network enrichment construction logistic regression models. Subsequently, Mendelian randomization was used to assess causal relationship between different markers Results This identified IREB2, LAMP2, ISCU, ATP6V1G1, ATP13A2, SKP1 as genes multiple metabolism, establishing their multi-gene diagnostic value an AUC 0.83. Additionally, analysis revealed a potential transferrin saturation (p=2.22E-02; OR 95%CI=0.86 (0.75, 0.98)), well serum (p=2.18E-04; 95%CI=1.22 (1.10, 1.36)). Conclusion comprehensively explored through integrated methods. findings provide important insights further into role in pathogenesis offer crucial theoretical support treatment

Language: Английский

Citations

11
The ageing central nervous system in multiple sclerosis: the imaging perspective DOI Creative Commons
Massimo Filippi, Paolo Preziosa, Frederik Barkhof

et al.

Brain, Journal Year: 2024, Volume and Issue: 147(11), P. 3665 - 3680

Published: July 22, 2024

Abstract The interaction between ageing and multiple sclerosis is complex carries significant implications for patient care. Managing effectively requires an understanding of how impact brain structure function. Ageing inherently induces changes, including reduced plasticity, diminished grey matter volume, ischaemic lesion accumulation. When combined with pathology, these age-related alterations may worsen clinical disability. also influence the response patients to therapies and/or their side effects, highlighting importance adjusted treatment considerations. MRI highly sensitive age- sclerosis-related processes. Accordingly, can provide insights into relationship sclerosis, enabling a better pathophysiological interplay informing selection. This review summarizes current knowledge on immunopathological aspects in CNS context sclerosis. Starting from immunosenescence, ageing-related pathological mechanisms specific features like enlarged Virchow-Robin spaces, this then explores aspects, late-onset age diagnostic criteria, comorbidity effects imaging features. role neurodegeneration, iron dynamics myelin changes influenced by contribute defining patients, are discussed.

Language: Английский

Citations

10
Whole-Body Cryostimulation in Multiple Sclerosis: A Scoping Review DOI Open Access
Angelo Alito, Jacopo Maria Fontana,

Eleonora Franzini Tibaldeo

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(7), P. 2003 - 2003

Published: March 29, 2024

Multiple sclerosis (MS) is the most common cause of non-traumatic long-term disability in young adults. Whole-body cryostimulation (WBC) a cold-based physical therapy known to induce physiological exercise-mimicking changes cardiovascular, neuromuscular, immune, and endocrine systems influence functional psychological parameters by exposing human body cryogenic temperatures (≤−110 °C) for 2–3 min. The purpose this scoping review present an overall view on potential role WBC as adjuvant treatment MS. PubMed, ScienceDirect, Embase, Web Science were searched up 30 November 2023, total 13 articles included. may have beneficial antioxidant effects short-term There no significant enzymes, nitric oxide levels, metalloproteinase blood counts, rheology, biochemistry. can lead reduction fatigue improvement status, with effect both mental well-being. reported adverse effects. results suggest that complement therapeutic options patients MS, cold stimulation been shown activate processes improve mood, anxiety, fatigue.

Language: Английский

Citations

6
A fast, convenient and stable fluorescent probe for detecting Fe3+/2+ and its applications DOI

Ning Duan,

Leyuan Ding,

Shaoxiang Yang

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 60, P. 104473 - 104473

Published: May 31, 2024

Language: Английский

Citations

4
Mild Systemic Inflammation Increases Erythrocyte Fragility DOI Open Access
C Stuart, Carmen Jacob,

Aravinthan Varatharaj

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7027 - 7027

Published: June 27, 2024

There is growing evidence that inflammation impairs erythrocyte structure and function. We assessed the impact of mild systemic on fragility in three different settings. In order to investigate causation, osmotic was measured mice challenged with a live attenuated bacterial strain induce low-grade inflammation; significant increase observed. To gather associated humans, two observational studies were conducted. First, using retrospective study design, relationship between reticulocyte-based surrogate markers haemolysis high-sensitivity C-reactive protein investigated 9292 healthy participants UK Biobank project. Secondly, we prospectively (measured by urinary neopterin/creatinine ratio) mixed population (n = 54) volunteers individuals long-term medical conditions. Both human keeping fragility. Taken together, conclude increases may contribute haemolysis. Further research needed assess molecular underpinnings this pathway clinical implications inflammatory

Language: Английский

Citations

4
Cerebral iron accumulation in multiple sclerosis: Pathophysiology and therapeutic implications DOI
Geir Bjørklund, David R. Wallace, Tony Hangan

et al.

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 103741 - 103741

Published: Jan. 1, 2025

Language: Английский

Citations

0
A benzimidazole-based ‘turn-on’ fluorescent probe for highly sensitive detection of Fe3+/2+: synthesis, performance, DFT calculations and applications DOI

Ning Duan,

Leyuan Ding,

Shaoxiang Yang

et al.

Journal of Materials Chemistry C, Journal Year: 2024, Volume and Issue: 12(20), P. 7359 - 7365

Published: Jan. 1, 2024

A benzimidazole-based ‘turn-on’ fluorescent probe was successfully used for highly sensitive detection of Fe 3+/2+ in wine.

Language: Английский

Citations

3