Опубликована: Янв. 1, 2024
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 786 - 786
Опубликована: Янв. 8, 2024
Studies on bionanocomposite drug carriers are a key area in the field of active substance delivery, introducing innovative approaches to improve therapy. Such play crucial role enhancing bioavailability substances, affecting therapy efficiency and precision. The targeted delivery drugs sites action minimization toxicity body is becoming possible through use these advanced carriers. Recent research has focused structures based biopolymers, including lipids, polysaccharides, proteins. This review paper description lipid-containing nanocomposite (including liposomes, lipid emulsions, nanoparticles, solid nanostructured carriers), polysaccharide-containing alginate cellulose), protein-containing (e.g., gelatin albumin). It was demonstrated many investigations that such show ability load therapeutic substances efficiently precisely control release. They also desirable biocompatibility, which promising sign for their potential application development indicates novel approach improving processes, contribute significant advances pharmacology, efficacy while minimizing side effects.
Язык: Английский
Процитировано
24
Nano TransMed, Год журнала: 2024, Номер 3, С. 100040 - 100040
Опубликована: Июнь 27, 2024
Currently, cancer is the leading cause of death globally. In absence specific treatment and early diagnosis, procedures like surgery, chemotherapy, radiation therapy are often used to manage disease. However, these approaches fail control due inefficacy, nonspecific distribution, side effects drugs. Anticancer drugs essential in reducing cell growth helping damage those cells. severe have limited bioavailability their distribution throughout body. Therefore, development intelligent drug release systems essential. Nanoparticle delivery promising strategies improve therapeutic efficacy safety, overcoming challenges. Among systems, a natural polysaccharide called chitosan, derivative chitin, has gained considerable attention as biocompatible, biodegradable, mucoadhesive material for creating nanoparticles. Chitosan nanoparticles provide several advantages, including improved stability, cellular uptake, solubility anticancer drugs, modulation kinetics, biodistribution. Additionally, chitosan can be modified on surface with ligands or stimuli-responsive moieties achieve targeted cells tissues. This review explores recent advances chitosan-based nanoparticle delivery, efficacy, applications therapy.
Язык: Английский
Процитировано
24
Materials, Год журнала: 2024, Номер 17(17), С. 4255 - 4255
Опубликована: Авг. 28, 2024
Today, smart materials are commonly used in various fields of science and technology, such as medicine, electronics, soft robotics, the chemical industry, automotive field, many others. Smart polymeric hold good promise for future due to their endless possibilities. This group advanced can be sensitive changes or presence chemical, physical, biological stimuli, e.g., light, temperature, pH, magnetic/electric pressure, microorganisms, bacteria, viruses, toxic substances, review concerns newest achievements area materials. The recent advances designing stimuli-responsive polymers described this paper.
Язык: Английский
Процитировано
10
AIP Advances, Год журнала: 2025, Номер 15(4)
Опубликована: Апрель 1, 2025
Triboelectric nanogenerators (TENGs), as a revolutionary energy-harvesting technology, have garnered widespread attention in the scientific community for their efficient conversion of mechanical energy into electrical energy. This article first outlines five working modes TENGs: vertical contact-separation mode, horizontal sliding single-electrode independent layer and free-standing rotating elaborates on principles detail. Subsequently, this delves application examples TENGs wearable health monitoring devices, implantable medical environmental monitoring, fully demonstrating vast potential TENG technology monitoring. In addition, analyzes advantages including its self-powered characteristics, high sensitivity, good biocompatibility, while also pointing out challenges that it faces, such improving long-term stability, enhancing efficiency, adaptability. review aims to explore progress analyze challenges, look forward future development directions. Through systematic analysis existing literature, will provide researchers developers with in-depth insights guiding research product development.
Язык: Английский
Процитировано
2
Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 249, С. 114507 - 114507
Опубликована: Янв. 8, 2025
Organ-on-a-chip systems, also referred to as microphysiological systems (MPS), represent an advance in bioengineering microsystems designed mimic key aspects of human organ physiology and function. Drawing inspiration from the intricate hierarchical architecture body, these innovative platforms have emerged invaluable vitro tools with wide-ranging applications drug discovery development, well enhancing our understanding disease physiology. The facility replicate tissues within physiologically relevant three-dimensional multicellular environments empowers organ-on-a-chip versatility throughout different stages development process. Moreover, can be tailored specific states, facilitating investigation progression, responses, potential therapeutic interventions. In particular, they demonstrate, early-phase pre-clinical studies, safety toxicity profiles compounds. Furthermore, play a pivotal role evaluation efficacy modeling diseases. One most promising prospects technology is simulate pathophysiology subpopulations even individual patients, thereby being used personalized medicine. By mimicking physiological responses diverse patient groups, hold promise revolutionizing strategies, guiding them towards intervention unique needs each patient. This review presents status evolution microfluidic that facilitated transition cells organs recreated on chips some opportunities offered by technology. Additionally, current future perspectives challenges this still faces are discussed.
Язык: Английский
Процитировано
1
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 9, 2025
Язык: Английский
Процитировано
1
Materials Technology, Год журнала: 2024, Номер 40(1)
Опубликована: Дек. 16, 2024
Global cancer mortality is rising yearly due to various factors. Silver nanoparticles (AgNPs) are widely utilized for their low cost and antibacterial properties compared other noble metals. Here, AgNPs were synthesized using Cucurbita maxima leaf extract, which was analyzed by analytical instruments. UV-visible spectra showed an absorbance peak in the 410-420 nm range, while Fourier transform infrared exhibited bands at 653 cm−1, 1629, 2276, 3786 cm−1. X-ray diffraction major intensity peaks 38.1º two theta value with average crystallite size of 18.34 nm. The transmission electron microscope aggregation spherical-shaped AgNPs, 10-90 MTT assay that it highly effective against SiHa cervical cells a much lower IC50 (~8 µg/mL) capable pesticide removal highest efficiency pH 9.
Язык: Английский
Процитировано
7
Journal of Photochemistry and Photobiology C Photochemistry Reviews, Год журнала: 2024, Номер 59, С. 100665 - 100665
Опубликована: Июнь 1, 2024
Язык: Английский
Процитировано
6
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 272, С. 132888 - 132888
Опубликована: Июнь 1, 2024
Язык: Английский
Процитировано
5
Bioorganic Chemistry, Год журнала: 2025, Номер 157, С. 108305 - 108305
Опубликована: Фев. 23, 2025
Язык: Английский
Процитировано
0