International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(7), С. 3617 - 3617
Опубликована: Март 23, 2024
Curcumin
is
a
polyphenolic
molecule
derived
from
the
rhizoma
of
Curcuma
longa
L.
This
compound
has
been
used
for
centuries
due
to
its
anti-inflammatory,
antioxidant,
and
antimicrobial
properties.
These
make
it
ideal
preventing
treating
skin
inflammation,
premature
ageing,
psoriasis,
acne.
Additionally,
exhibits
antiviral,
antimutagenic,
antifungal
effects.
provides
protection
against
damage
caused
by
prolonged
exposure
UVB
radiation.
It
reduces
wound
healing
times
improves
collagen
deposition.
Moreover,
increases
fibroblast
vascular
density
in
wounds.
review
summarizes
available
information
on
therapeutic
effect
curcumin
diseases.
The
results
suggest
that
may
be
an
inexpensive,
well-tolerated,
effective
agent
However,
larger
clinical
trials
are
needed
confirm
these
observations
limitations
vivo
use,
such
as
low
bioavailability
after
oral
administration
metabolism.
Materials Today Bio,
Год журнала:
2024,
Номер
26, С. 101093 - 101093
Опубликована: Май 18, 2024
The
incidence
of
chronic
wound
healing
is
promoted
by
the
growing
trend
elderly
population,
obesity,
and
type
II
diabetes.
Although
numerous
dressings
have
been
studied
over
years,
it
still
challenging
for
many
to
perfectly
adapt
process
due
dynamic
complicated
microenvironment.
Aiming
at
an
optimal
reproduction
physiological
environment,
multifunctional
electrospinning
nanofibrous
membranes
(ENMs)
emerged
as
a
promising
platform
treatment
owing
their
resemblance
extracellular
matrix
(ECM),
adjustable
preparation
processes,
porousness,
good
conformability
site.
Moreover,
profiting
from
booming
development
human-machine
interaction
artificial
intelligence,
next
generation
intelligent
(iENMs)
based
dressing
substrates
that
could
realize
real-time
monitoring
proceeding
individual-based
therapy
has
evoked
surge
interest.
In
this
regard,
general
wound-related
biomarkers
are
overviewed
firstly
representative
iENMs
stimuli-responsive
materials
briefly
summarized.
Subsequently,
emergent
applications
highlighted.
Finally,
opportunities
challenges
next-generation
well
translating
into
clinical
practice
evaluated.
Nano Materials Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Inspired
by
the
skin
structure,
an
asymmetric
wettability
tri-layer
nanofiber
membrane
(TNM)
consisting
of
hydrophilic
inner
layer
loaded
with
lidocaine
hydrochloride
(LID),
hydrophobic
middle
ciprofloxacin
(CIP)
and
outer
has
been
created.
The
endows
TNM
waterproof
function
anti-adhesion
from
contaminants.
CIP
preserves
long-term
inhibition
bacteria
growth
LID
possesses
optimal
water-absorbing
capacity
air
permeability.
dramatically
elevates
water
contact
angles
10°
(inner
layer)
to
120°
(outer
layer),
indicating
wettability,
which
could
directionally
transport
wound
exudate
within
materials
meanwhile
maintain
a
comfortable
moist
environment
promote
healing.
Furthermore,
sequential
release
relieve
pain
rapidly
achieve
antibacterial
effect
in
long
run,
respectively.
In
addition,
shows
superior
biocompatibility
towards
L929
cells.
vivo
results
show
prevent
infection,
accelerate
epithelial
regeneration
significantly
This
study
indicates
developed
asymmetrical
synergetic
drug
great
potential
as
dressing
clinical
application.
