MedComm – Biomaterials and Applications,
Год журнала:
2022,
Номер
1(2)
Опубликована: Сен. 1, 2022
Abstract
Photothermal
therapy
(PTT)
has
been
regarded
as
a
promising
strategy
considering
its
advantages
of
high
inherent
specificity
and
lower
invasive
burden.
Since
the
photothermal
killing
cells/bacteria
showed
different
patterns
death
depending
on
varying
temperature
in
PTT,
change
PTT
is
vital
to
cell/tissue
response
scientific
research
clinical
application.
On
one
hand,
mild
received
substantial
attention
treatment
cancer
soft/hard
tissue
repair.
other
induced
by
capable
antibacterial
capacity,
which
better
than
conventional
antibiotic
with
drug
resistance.
Herein,
we
summarize
recent
developments
application
temperature‐dependent
biomaterials,
mainly
covering
ranges
40–42°C,
43–50°C,
over
50°C.
We
highlight
biological
mechanism
latest
progress
diseases.
Finally,
conclude
discussing
challenges
perspectives
biomaterials
addressing
temperature‐orchestrated
PTT.
Given
deep
understanding
interaction
between
biology,
rationally
designed
sophisticated
responsiveness
will
benefit
outcomes
personalized
toward
various
RSC Advances,
Год журнала:
2023,
Номер
13(25), С. 16773 - 16788
Опубликована: Янв. 1, 2023
Self-healing
hydrogels
respond
rapidly,
autonomously,
and
repeatedly
to
induced
damage
can
maintain
their
original
properties.
This
review
focuses
on
applications
in
bone
defect
repair
we
discussed
the
recent
progress
this
field.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(22), С. 26349 - 26362
Опубликована: Май 24, 2023
Platelet-rich
fibrin
(PRF)
is
an
autologous
growth
factor
carrier
that
promotes
bone
tissue
regeneration,
but
its
effectiveness
restrained
by
poor
storage
capabilities,
uncontrollable
concentration
of
factors,
unstable
shape,
etc.
Herein,
we
developed
a
photocrosslinkable
composite
hydrogel
incorporating
lyophilized
PRF
exudate
(LPRFe)
into
the
carboxymethyl
chitosan
methacryloyl
(CMCSMA)/gelatin
(GelMA)
to
effectively
solve
dilemma
PRF.
The
possessed
suitable
physical
properties
and
sustainable
release
ability
factors
in
LPRFe.
LPRFe-loaded
could
improve
adhesion,
proliferation,
migration,
osteogenic
differentiation
rat
mesenchymal
stem
cells
(BMSCs).
Furthermore,
animal
experiments
demonstrated
excellent
biocompatibility
biodegradability,
introduction
LPRFe
can
accelerate
healing
process.
Conclusively,
combination
with
CMCSMA/GelMA
may
be
promising
therapeutic
approach
for
defects.
Heliyon,
Год журнала:
2024,
Номер
10(16), С. e36258 - e36258
Опубликована: Авг. 1, 2024
Natural
bone
tissue
has
the
certain
function
of
self-regeneration
and
repair,
but
it
is
difficult
to
repair
large
damage.
Recently,
although
autologous
grafting
"gold
standard"
for
improving
high
cost,
few
donor
sources.
Besides,
allogeneic
causes
greater
immune
reactions,
which
hardly
meet
clinical
needs.
The
engineering
(BTE)
been
developed
promote
repair.
Gelatin,
due
its
biocompatibility,
receives
a
great
deal
attention
in
BTE
research
field.
However,
disadvantages
natural
gelatin
are
poor
mechanical
properties
single
structural
property.
With
development
BTE,
often
used
combination
with
range
natural,
synthetic
polymers,
inorganic
materials
achieve
synergistic
effects
complex
physiological
process
review
delves
into
fundamental
structure
unique
gelatin,
as
well
excellent
necessary
scaffold
materials.
Then
this
explores
application
modified
three-dimensional
(3D)
scaffolds
various
structures
including
3D
fiber
scaffolds,
hydrogels,
nanoparticles.
In
addition,
focuses
on
efficacy
composite
consisting
or
polymeric
materials,
bioactive
ceramics
metallic/non-metallic
defects.
these
gelatin-based
provides
new
ideas
design
good
biosafety.
Abstract
Cartilage
defects
resulting
from
injury
or
degeneration
are
a
common
clinical
problem,
and
due
to
its
avascular
nature,
articular
cartilage
has
poor
self‐healing
capacity.
Three‐dimensional
(3D)
bioprinting
attracted
great
attention
in
tissue
engineering.
Melatonin
(MT),
hormone
mainly
secreted
at
night,
plays
an
important
role
repair.
Small
extracellular
vesicles
(sEV)
considered
ideal
drug
delivery
vehicles
MT‐sEV
(sleep‐related
sEV)
have
the
potential
ability
promote
regeneration.
Here,
biomimetic
multilayer
scaffolds
were
fabricated
using
3D
bioprinting.
A
double
network
hydrogel,
composed
of
methacrylated
hyaluronic
acid
gelatin
methacryloyl
(HG),
was
prepared.
HG
hydrogel
used
create
layer.
bone
layer
formed
poly(ε‐caprolactone)
hydroxyapatite
ultralong
nanowires.
Additionally,
two
bioinks
alternately
printed
interface
The
results
RNA
sequencing
revealed
regulatory
mechanisms.
showed
promotional
effects
on
cell
migration,
proliferation,
chondrogenic
differentiation,
matrix
(ECM)
deposition.
Moreover,
altered
macrophage
polarization
regulated
expression
inflammatory
cytokines.
In
vivo
experiments
demonstrated
that
promoted
These
regulate
immune
microenvironment
secretion
ECM,
providing
promising
strategy
for
Abstract
Infectious
bone
defects
represent
a
substantial
challenge
in
clinical
practice,
necessitating
the
deployment
of
advanced
therapeutic
strategies.
This
study
presents
treatment
modality
that
merges
mild
photothermal
therapy
hydrogel
with
pulsed
drug
delivery
mechanism.
The
system
is
predicated
on
matrix
thermally
responsive,
characteristic
defect
sites,
facilitating
controlled
and
site-specific
release.
cornerstone
this
incorporation
nanoparticles,
which
are
activated
within
temperature
range
40–43
°C,
thereby
enhancing
precision
efficacy
delivery.
Our
findings
demonstrate
response
significantly
augments
localized
agents,
mitigating
systemic
side
effects
bolstering
at
site.
synchronized
release,
cooperated
therapy,
effectively
addresses
infection
control,
promotes
regeneration.
approach
signifies
considerable
advancement
management
infectious
defects,
offering
an
effective
patient-centric
alternative
to
traditional
methods.
research
endeavors
extend
its
applicability
wider
spectrum
tissue
regeneration
scenarios,
underscoring
transformative
potential
realm
regenerative
medicine.
Materials Today Bio,
Год журнала:
2023,
Номер
23, С. 100834 - 100834
Опубликована: Окт. 20, 2023
Achieving
precision
treatment
in
bone
tissue
engineering
(BTE)
remains
a
challenge.
Photothermal
therapy
(PTT),
as
form
of
therapy,
has
been
extensively
investigated
for
its
safety
and
efficacy.
It
demonstrated
significant
potential
the
orthopedic
diseases
such
tumors,
postoperative
infections
osteoarthritis.
However,
high
temperatures
associated
with
PTT
can
lead
to
certain
limitations
drawbacks.
In
recent
years,
researchers
have
explored
use
biomaterials
mild
photothermal
(MPT),
which
offers
promising
approach
addressing
these
limitations.
This
review
provides
comprehensive
overview
mechanisms
underlying
MPT
presents
compilation
agents
their
utilization
strategies
repair.
Additionally,
paper
discusses
future
prospects
MPT-assisted
regeneration,
aiming
provide
insights
recommendations
optimizing
material
design
this
field.
Bone
is
one
of
the
prone
metastatic
sites
patients
with
advanced
breast
cancer.
The
"vicious
cycle"
between
osteoclasts
and
cancer
cells
plays
an
essential
role
in
osteolytic
bone
metastasis
from
In
order
to
inhibit
cancer,
NIR-II
photoresponsive
bone-targeting
nanosystems
(CuP@PPy-ZOL
NPs)
are
designed
synthesized.
CuP@PPy-ZOL
NPs
can
trigger
photothermal-enhanced
Fenton
response
photodynamic
effect
enhance
photothermal
treatment
(PTT)
thus
achieve
synergistic
anti-tumor
effect.
Meanwhile,
they
exhibit
a
enhanced
ability
osteoclast
differentiation
promote
osteoblast
differentiation,
which
reshaped
microenvironment.
effectively
inhibited
proliferation
tumor
resorption
vitro
3D
metastases
model
mouse
metastasis,
combined
PTT
significantly
growth
osteolysis
while
promoting
repair
reversal
metastases.
Furthermore,
potential
biological
mechanisms
identified
by
conditioned
culture
experiments
mRNA
transcriptome
analysis.
design
this
nanosystem
provides
promising
strategy
for
treating
Advanced Functional Materials,
Год журнала:
2023,
Номер
34(2)
Опубликована: Сен. 26, 2023
Abstract
Near‐infrared
(NIR)
responsive
smart
drug
delivery
systems
could
provide
efficient
osteogenesis
through
the
synergy
of
heat
and
drugs.
However,
such
are
hampered
by
an
inability
to
allow
supersensitive
release
mild
heat.
Here
superior
is
demonstrated
using
a
biocompatible
dexamethasone
(Dex)‐loaded
MXene‐poly(
N
‐isopropylacrylamide)‐co‐
‐(Hydroxymethyl)
acrylamide
hydrogel
capable
Dex
at
≈42
°C
upon
NIR
irradiation.
Furthermore,
can
significantly
promote
bone
regeneration
under
irradiation
due
synergistic
anti‐apoptosis
osteogenic
differentiation
bone‐derived
mesenchymal
stem
cells
induced
Dex.
The
resulting
efficiency
hydrogels
surpass
efficiencies
previously
reported
for
stimulation
their
combination.
strategy
characterized
near‐instantaneous,
noninvasive,
precise
treatment
temporal
