Antioxidants,
Год журнала:
2024,
Номер
14(1), С. 17 - 17
Опубликована: Дек. 26, 2024
Spinal
cord
injury
(SCI)
initiates
a
cascade
of
secondary
damage
driven
by
oxidative
stress,
characterized
the
excessive
production
reactive
oxygen
species
and
other
molecules,
which
exacerbate
cellular
tissue
through
activation
deleterious
signaling
pathways.
This
review
provides
comprehensive
critical
evaluation
recent
advancements
in
antioxidant-based
therapeutic
strategies
for
SCI,
including
natural
compounds,
RNA-based
therapies,
stem
cell
interventions,
biomaterial
applications.
It
emphasizes
limitations
single-regimen
approaches,
particularly
their
limited
efficacy
suboptimal
delivery
to
injured
spinal
tissue,
while
highlighting
synergistic
potential
combination
therapies
that
integrate
multiple
modalities
address
multifaceted
pathophysiology
SCI.
By
analyzing
emerging
trends
current
limitations,
this
identifies
key
challenges
proposes
future
directions,
refinement
antioxidant
systems,
development
multi-targeted
overcome
structural
complexities
cord.
work
underscores
pressing
need
innovative
integrative
approaches
advance
clinical
translation
interventions
improve
outcomes
SCI
patients.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Янв. 28, 2025
Abstract
Hydrogel
drug-delivery
system
that
can
effectively
load
antibacterial
drugs,
realize
the
in-situ
drug
release
in
microenvironment
of
wound
infection
to
promote
healing.
In
this
study,
a
multifunctional
hydrogel
delivery
(HA@TA-Okra)
was
constructed
through
integration
hyaluronic
acid
methacrylate
(HAMA)
matrix
with
tannic
(TA)
and
okra
extract.
The
composition
structural
characteristics
HA@TA-Okra
its
unique
advantages
treatment
diverse
wounds
were
systematically
evaluated.
TA,
due
chemical
structure,
is
able
anchor
within
HAMA
network
interactions
cross-linking,
conferring
exceptional
mechanical
strength
stability
hydrogel.
Both
TA
extract
possess
antioxidant
properties,
when
they
two
acts
synergistically
scavenge
free
radicals,
enhance
action,
diminishing
risk
infection.
vitro
experiments
revealed
has
superior
such
as
rapid
gel
response,
remarkable
swelling
regulation,
potent
ability.
Furthermore,
significantly
outperformed
conventional
dressings
terms
hemostatic
performance
rat
hemorrhage
model.
We
further
evaluated
repair
role
vivo
by
establishing
an
animal
model
full-thickness
skin
defects
infected
total
defects.
results
confirmed
positive
effects
fighting
bacterial
infection,
reducing
inflammation
promoting
summary,
exhibits
comprehensive
properties
antibacterial,
which
potential
application
field
tissue
medicine.
Graphical
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Июль 24, 2023
Abstract
Functional
hydrogels
show
potential
application
in
repairing
spinal
cord
injury
(SCI)
due
to
their
unique
chemical,
physical,
and
biological
properties
functions.
In
this
comprehensive
review,
we
present
recent
advance
the
material
design,
functional
regulation,
SCI
repair
applications
of
bioactive
hydrogels.
Different
from
previously
released
reviews
on
three-dimensional
scaffolds
for
repair,
work
focuses
strategies
design
biologically
regulation
hydrogels,
specifically
aiming
how
these
significant
efforts
can
promoting
performance
SCI.
We
demonstrate
various
methods
techniques
fabrication
with
components
such
as
DNA,
proteins,
peptides,
biomass
polysaccharides,
biopolymers
obtain
including
cell
biocompatibility,
self-healing,
anti-bacterial
activity,
injectability,
bio-adhesion,
bio-degradation,
other
multi-functions
The
drugs/growth
factors,
polymers,
nanoparticles,
one-dimensional
materials,
two-dimensional
materials
highly
effective
treating
are
introduced
discussed
detail.
This
shows
new
viewpoints
ideas
synthesis
state-of-the-art
knowledges
science
nanotechnology,
will
bridge
connection
biomedicine,
further
inspire
clinical
biomedical
fields.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(31), С. 37193 - 37204
Опубликована: Июль 26, 2023
Mesenchymal
stem
cell
(MSC)-based
therapy
has
emerged
as
a
promising
strategy
for
the
treatment
of
spinal
cord
injury
(SCI).
However,
hostile
microenvironment
SCI,
which
can
adversely
affect
survival
and
paracrine
effect
implanted
MSCs,
severely
limits
therapeutic
efficacy
this
approach.
Here,
we
report
on
ceria
nanozyme-integrated
thermoresponsive
in
situ
forming
hydrogel
(CeNZ-gel)
that
enable
dual
enhancement
MSC
viability
effect,
leading
to
highly
efficient
repair.
The
sol-gel
transition
property
CeNZ-gel
at
body
temperature
ensures
uniform
coverage
injured
tissues.
Our
results
demonstrate
significantly
increases
transplanted
MSCs
by
attenuating
oxidative
stress
and,
more
importantly,
promotes
secretion
angiogenic
factors
from
inducing
autophagy
MSCs.
synergy
between
stress-relieving
CeNZs
accelerates
angiogenesis,
nerve
repair,
motor
function
recovery
after
providing
an
MSC-based
SCI
therapy.
Theranostics,
Год журнала:
2023,
Номер
14(2), С. 510 - 527
Опубликована: Дек. 5, 2023
Spinal
cord
injury
(SCI)
results
in
neural
tissue
damage.
However,
the
limited
regenerative
capacity
of
adult
mammals'
axons
upon
SCI
leads
to
persistent
neurological
dysfunction.
Thus,
exploring
pathways
that
can
enhance
axon
regeneration
injured
spinal
is
great
significance.
