Harnessing genetic engineering to drive economic bioproduct production in algae

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12

Опубликована: Янв. 29, 2024

Our reliance on agriculture for sustenance, healthcare, and resources has been essential since the dawn of civilization. However, traditional agricultural practices are no longer adequate to meet demands a burgeoning population amidst climate-driven challenges. Microalgae emerge as beacon hope, offering sustainable renewable source food, animal feed, energy. Their rapid growth rates, adaptability non-arable land non-potable water, diverse bioproduct range, encompassing biofuels nutraceuticals, position them cornerstone future resource management. Furthermore, microalgae’s ability capture carbon aligns with environmental conservation goals. While microalgae offers significant benefits, obstacles in cost-effective biomass production persist, which curtails broader application. This review examines compared other host platforms, highlighting current innovative approaches aimed at overcoming existing barriers. These include range techniques, from gene editing, synthetic promoters, mutagenesis selective breeding metabolic engineering through transcription factors.

Язык: Английский

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Review on mushroom mycelium-based products and their production process: from upstream to downstream

Bioresources and Bioprocessing, Год журнала: 2025, Номер 12(1)

Опубликована: Янв. 10, 2025

Abstract The global trend toward carbon neutrality and sustainability calls for collaborative efforts in both the basic applied research sectors to utilize mushroom mycelia as environmentally friendly sustainable materials. Fungi, along with animals plants, are one of major eukaryotic life forms. They have long been utilized traditional biotechnology sectors, such food fermentation, antibiotic production, industrial enzyme production. Some fungi also consumed crops, fruiting bodies various mushrooms. Recently, new trends emerged, shifting from applications towards innovative use mycelium eco-friendly bioresources. This approach has gained attention development alternative meats, mycofabrication biocomposites, production mycelial leather fabrics. These aim replace animal husbandry recycle agricultural waste construction electrical paper reviews current on mycelia, covering strain improvements molecular breeding well products processes. Key findings, practical considerations, valorization discussed. Graphical

Язык: Английский

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Fungal Engineered Living Materials: The Viability of Pure Mycelium Materials with Self‐Healing Functionalities

Advanced Functional Materials, Год журнала: 2023, Номер 33(29)

Опубликована: Апрель 11, 2023

Abstract Engineered living materials (ELMs) composed entirely of fungal cells offer significant potential due to their functional properties such as self‐assembly, sensing, and self‐healing. Alongside rapid developments in the ELM field, there is growing interest mycelium materials, which are made from vegetative part filamentous fungi, a source advanced materials. In order advance development ELMs that utilize organism's ability regenerate self‐repair, new methods for controlling optimizing needed, well better understanding biological mechanisms behind regeneration. this study, pure fabricated use leather substitutes, it found chlamydospores, thick‐walled formed at hyphal tip, may be key material's self‐healing properties. The results suggest can survive dry oligotrophic environments, possible with minimal intervention after two‐day recovery period. Finally, study characterizes mechanical physical damaged healed samples, allowing first characterization ELMs.

Язык: Английский

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Sustainable Mycelium-Bound Biocomposites: Design Strategies, Materials Properties, and Emerging Applications

ACS Sustainable Chemistry & Engineering, Год журнала: 2023, Номер 11(18), С. 6801 - 6821

Опубликована: Апрель 26, 2023

Extrication from the use of fossil-based products has grown more critical in recent years. This disengagement been driven by deliberate environmental campaigns focusing on climate change and global warming threats their consequences to humanity. As such, innovative replacements for products, primarily biobased materials, have recently considerable interest. Among mycelium-bound biocomposites enhanced biologically or nontoxic additives are one most creative ecofriendly solutions because it fulfills three pillars sustainable development with positive impacts via circular economy design principles. In this review, potential is elucidated comprehensively covering state-of-the-art production strategies (variety species, substrates, additives, growth conditions) postprocessing techniques resulting advanced material features. review also covers intriguing growing areas applications biocomposites, as well future outlook circularity sustainability.

Язык: Английский

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Aspergillus oryzae as a Cell Factory: Research and Applications in Industrial Production

Journal of Fungi, Год журнала: 2024, Номер 10(4), С. 248 - 248

Опубликована: Март 26, 2024

Aspergillus oryzae, a biosafe strain widely utilized in bioproduction and fermentation technology, exhibits robust hydrolytic enzyme secretion system. Therefore, it is frequently employed as cell factory for industrial production. Moreover, A. oryzae has the ability to synthesize various secondary metabolites, such kojic acid L-malic acid. Nevertheless, complex system protein expression regulation mechanism of pose challenges expressing numerous heterologous products. By leveraging synthetic biology novel genetic engineering techniques, emerged an ideal candidate constructing factories. In this review, we provide overview latest advancements application oryzae-based factories These studies suggest that metabolic optimization are key elements realizing widespread It anticipated review will pave way more effective approaches research avenues future implementation

Язык: Английский

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Open-endedness in synthetic biology: A route to continual innovation for biological design

Science Advances, Год журнала: 2024, Номер 10(3)

Опубликована: Янв. 19, 2024

Design in synthetic biology is typically goal oriented, aiming to repurpose or optimize existing biological functions, augmenting with new-to-nature capabilities, creating life-like systems from scratch. While the field has seen many advances, bottlenecks complexity of built are emerging and designs that function lab often fail when used real-world contexts. Here, we propose an open-ended approach design, novelty designed being at least as important how well it fulfils its goal. Rather than solely focusing on optimization toward a single best designing mind may allow us move beyond diminishing returns see performance for most engineered biology. Research artificial life community demonstrated embracing can automatically generate innovative unexpected solutions challenging problems local optima. Synthetic offers ideal playground explore more creative approaches design.

Язык: Английский

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Current utilization technologies and products of antibiotic fermentation residues: A review

Journal of environmental chemical engineering, Год журнала: 2025, Номер unknown, С. 116182 - 116182

Опубликована: Март 1, 2025

Язык: Английский

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Exploring the Application and Prospects of Synthetic Biology in Engineered Living Materials

Advanced Materials, Год журнала: 2023, Номер unknown

Опубликована: Сен. 7, 2023

At the intersection of synthetic biology and materials science, engineered living (ELMs) exhibit unprecedented potential. Possessing unique "living" attributes, ELMs represent a significant paradigm shift in material design, showcasing self-organization, self-repair, adaptability, evolvability, surpassing conventional materials. This review focuses on reviewing applications derived from bacteria, fungi, plants environmental remediation, eco-friendly architecture, sustainable energy. The provides comprehensive overview latest research progress emerging design strategies for various application fields perspectives science. In addition, valuable references novel ELMs, extending potential future ELMs. investigation into synergistic possibilities amongst different species offers beneficial reference information researchers practitioners this field. Finally, trends development challenges coming years are discussed detail.

Язык: Английский

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Current Advances in the Functional Genes of Edible and Medicinal Fungi: Research Techniques, Functional Analysis, and Prospects

Journal of Fungi, Год журнала: 2024, Номер 10(5), С. 311 - 311

Опубликована: Апрель 25, 2024

Functional genes encode various biological functions required for the life activities of organisms. By analyzing functional edible and medicinal fungi, varieties fungi can be improved to enhance their agronomic traits, growth rates, ability withstand adversity, thereby increasing yield quality promoting industrial development. With rapid development gene research technology publication many whole-genome sequences related important traits have been mined, located, functionally analyzed. This paper summarizes advantages disadvantages different techniques application examples fungi; systematically reviews progress in processes such as mating type, mycelium fruit development, substrate utilization nutrient transport, environmental response, synthesis regulation active substances; proposes future directions fungi. The overall aim this study was provide a valuable reference further molecular breeding with high promote wide products food, medicine, industry.

Язык: Английский

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Beyond Penicillin: The Potential of Filamentous Fungi for Drug Discovery in the Age of Antibiotic Resistance

Antibiotics, Год журнала: 2023, Номер 12(8), С. 1250 - 1250

Опубликована: Июль 29, 2023

Antibiotics are a staple in current medicine for the therapy of infectious diseases. However, their extensive use and misuse, combined with high adaptability bacteria, has dangerously increased incidence multi-drug-resistant (MDR) bacteria. This makes treatment infections challenging, especially when MDR bacteria form biofilms. The most recent antibiotics entering market have very similar modes action to existing ones, so rapidly catch up those as well. As such, it is important adopt effective measures avoid development antibiotic resistance by pathogenic but also perform bioprospecting new molecules from diverse sources expand arsenal drugs that available fight these Filamentous fungi large vastly unexplored secondary metabolome rich bioactive can be potential novel antimicrobial drugs. Their production associated biosynthetic pathways may not active under standard culture conditions. New techniques involving metabolic genetic engineering help boost production. study aims review bioprospection produce face growing problem biofilm-associated infections.

Язык: Английский

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