Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 27, 2024
Abstract
Uncontrolled
traumatic
hemorrhage
is
a
leading
cause
of
preventable
death.
As
two
main
forms
hemostatic
materials,
however,
both
sponges
and
hydrogel
adhesives
usually
fail
to
control
massive
due
their
respective
shortcomings.
Hemostatic
sponge
shows
weak
tissue
adhesion,
while
the
gelation
process
makes
it
difficult
seal
high‐pressure
bleeding
wounds.
There
an
urgent
need
develop
next‐generation
hemostats
combining
advantages
adhesives.
Herein,
general
methodology
prepare
novel
Fe
3+
‐laden
porous
material
(Fe
@GCS)
for
rapid
hemostasis
severe
hemorrhages
proposed,
which
fabricated
by
loading
ferric
chloride
with
ethanol
into
catechol‐modified
carboxylated
gelatin
(GCS).
Notably,
@GCS
can
undergo
water‐triggered
transformation
robust‐adhesive
hydrogels.
The
sealing
strength
on
wet
tissues
reaches
astonishing
≈600
mm
Hg.
Rapid
water
uptake
around
wound
not
only
concentrates
blood
components
but
also
excludes
interfacial
water,
facilitating
clotting
in
situ
formed
sticky
hydrogel.
efficiently
stop
hemorrhaging
from
injuries
arteries
hearts
rats
pigs,
respectively,
via
simple
short‐time
pressing.
Furthermore,
promotes
repair
healing.
Materials Today Bio,
Год журнала:
2024,
Номер
24, С. 100946 - 100946
Опубликована: Янв. 7, 2024
Recently,
biomacromolecules
have
received
considerable
attention
in
hemostatic
materials.
Collagen,
an
ideal
candidate
for
sponges
due
to
its
involvement
the
clotting
process,
has
been
facing
challenges
extraction
from
raw
materials,
which
is
time-consuming,
expensive,
and
limited
by
cultural
religious
restrictions
associated
with
traditional
livestock
poultry
sources.
To
address
these
issues,
this
study
explored
a
new
shortcut
method
that
using
wild
Communications Materials,
Год журнала:
2024,
Номер
5(1)
Опубликована: Июль 21, 2024
Abstract
Massive
hemorrhage
following
tissue
trauma
has
high
mortality
owing
to
the
lack
of
timely
intervention.
However,
research
on
utilizing
hemostats
for
humans
is
limited;
therefore,
developing
an
efficient
emergency
hemostatic
agent
imperative.
We
developed
a
sponge
using
natural
polysaccharide
riclin,
theoretically
modified
with
50%
aldehyde
content
(AR50).
The
AR50
sponge,
quasi-honeycomb
channels
and
appropriate
content,
exhibits
ultra-high
blood
absorption
(59.4
g·g
−1
)
rapidly
targets
erythrocytes
platelets
form
stable
barrier.
It
surpasses
most
commercial
in
porcine
artery
scission
(reducing
hemostasis
time
loss
by
53
s
4.2
g),
hepatic
bleeding
laceration
(68
2.6
perforation
models
(140
4.9
g).
easily
removed
post
hemostasis,
antibacterial
properties
destroying
bacterial
cell
walls,
safely
absorbed
day
5,
making
it
ideal
massive
hemorrhages
humans.
Polymers,
Год журнала:
2024,
Номер
16(13), С. 1937 - 1937
Опубликована: Июль 6, 2024
Over
millions
of
years
evolution,
nature
has
developed
a
myriad
unique
features
that
have
inspired
the
design
adhesives
for
wound
healing.
Bionic
hydrogel
adhesives,
capable
adapting
to
dynamic
movements
tissues,
possess
superior
biocompatibility
and
effectively
promote
healing
both
external
internal
wounds.
This
paper
provides
systematic
review
principles
these
focusing
on
treatment
skin
wounds,
explores
feasibility
incorporating
nature-inspired
properties
into
their
design.
The
adhesion
mechanisms
bionic
are
analyzed
from
chemical
physical
perspectives.
Materials
natural
synthetic
polymers
commonly
used
as
detailed
regarding
degradability.
multifunctional
elements
trauma
treatment,
such
self-healing,
drug
release,
responsive
design,
optimization
mechanical
properties,
further
explored.
aim
is
overcome
limitations
conventional
treatments
offer
safer,
more
effective
solution
application
dressings.
Materials Today Bio,
Год журнала:
2023,
Номер
20, С. 100682 - 100682
Опубликована: Май 27, 2023
Articular
cartilage,
composed
of
collagen
type
II
as
a
major
extracellular
matrix
and
chondrocyte
unique
cell
type,
is
specialized
connective
tissue
without
blood
vessels,
lymphatic
vessels
nerves.
This
distinctive
characteristic
articular
cartilage
determines
its
very
limited
ability
to
repair
when
damaged.
It
well
known
that
physical
microenvironmental
signals
regulate
many
behaviors
such
morphology,
adhesion,
proliferation
communication
even
determine
fate.
Interestingly,
with
increasing
age
or
progression
joint
diseases
osteoarthritis
(OA),
the
fibrils
in
become
larger
diameter,
leading
stiffening
reducing
resistance
external
tension,
which
turn
aggravates
damage
diseases.
Therefore,
designing
microenvironment
closer
real
thus
obtaining
data
cellular
behaviour,
then
revealing
biological
mechanisms
chondrocytes
pathological
states
crucial
importance
for
treatment
OA
disease.
Here
we
fabricated
micropillar
substrates
same
topology
but
different
stiffnesses
mimic
occurs
transition
from
normal
diseased
cartilage.
was
first
found
responded
stiffened
by
showing
spreading
area,
stronger
enhancement
cytoskeleton
rearrangement
more
stability
focal
adhesion
plaques.
The
activation
Erk/MAPK
signalling
detected
response
substrate.
nuclear
area
at
interface
layer
between
cells
top
surfaces
micropillars
observed
Finally,
it
substrate
promoted
hypertrophy.
Taken
together,
these
results
revealed
responses
terms
cytoskeleton,
nuclei
hypertrophy,
may
be
beneficial
understanding
functional
changes
affected
during
state
osteoarthritis.
Advances in medical education, research, and ethics (AMERE) book series,
Год журнала:
2025,
Номер
unknown, С. 119 - 146
Опубликована: Янв. 10, 2025
Speech
impairment
presents
a
significant
challenge
for
aged
and
chronically
ill
individuals.
Emerging
assistive
technologies
offer
promising
solutions
to
improve
their
communication
abilities.
This
discussion
explores
established
options
like
Augmentative
Alternative
Communication
(AAC)
devices
cutting-edge
approaches
Brain-Computer
Interfaces
(BCIs).
Neuroprosthetics,
field
merging
neuroscience
biomedical
engineering,
aims
replace
or
modulate
damaged
parts
of
the
nervous
system.
We
delved
into
potential
optogenetics,
neuroengineering
devices,
biosensors,
highlighting
contributions
future
advancements
in
speech
assistance.
The
dialogue
emphasized
importance
comprehensive
approach,
combining
with
ongoing
research
on
areas
synthetic
biology.
multi-faceted
approach
holds
key
empowering
speech-impaired
individuals
fostering
improved
communication.
