Biomaterials Science, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Modulation of collagen fibrillogenesis by varying the degrees chitosan deacetylation for preparation co-assembled biomimetic fibrils to enhance hemostasis.
Язык: Английский
Food Chemistry, Год журнала: 2024, Номер 455, С. 139943 - 139943
Опубликована: Июнь 1, 2024
Язык: Английский
Процитировано
6
ACS Omega, Год журнала: 2025, Номер unknown
Опубликована: Янв. 13, 2025
Natural jellyfish collagen (JC) has garnered significant attention in the field of hemostasis due to its oceanic origin, nontoxicity, biodegradability, and absence complications related diseases religious beliefs. However, hemostatic performance pure JC is limited by poor stability, adhesion wet tissue, mechanical properties. We developed a novel (HJP) sponge comprising JC, protocatechuic acid (PA), hydroxybutyl chitosan (HS) enhance application emergency hemostasis. This exhibits antibacterial properties, good biocompatibility, tissue adhesion, capabilities. The HJP demonstrates excellent thermal stability strength (tensile strength: ∼106.6 kPa, compressive at 70% strain: ∼1013.5 kPa) strong (∼117.1 kPa). Upon wound, rapidly forms wound seal, achieving effective through synergistic action PA JC. blood loss was also reduced 0.105 g when compared commercial gelatin sponge. JC-based sponge, with multifaceted characteristics, holds promise for rapid clinical applications.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140337 - 140337
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown
Опубликована: Март 3, 2025
Collagen, as the principal structural component of cornea, has emerged a promising biomaterial for artificial corneal owing to its excellent biocompatibility and degradability. However, mechanical properties current collagen membrane cannot match requirements materials. Inspired by hierarchical lamellar organization native stromal collagen, biomimetic collagen-based repair material was designed via "killing two birds with one stone" strategy. In this strategy, carboxymethyl-β-cyclodextrin (CM-β-CD) incorporated into serving dual functions: regulating in vitro self-assembly process molecules establishing multiple covalent cross-linking sites within network. Concurrently, controlled external shear forces were applied induce anisotropic alignment fibers, effectively replicating highly organized hierarchy characteristic tissue. The resulting exhibited 67% enhancement tensile strength (0.52 MPa) compared pure membranes. Notably, vivo keratoplasty evaluations revealed accelerated tissue regeneration, achieving complete re-epithelialization 14 days versus 28 controls. These findings establish material's potential an advanced engineering applications.
Язык: Английский
Процитировано
0
Deleted Journal, Год журнала: 2025, Номер 7(1)
Опубликована: Март 20, 2025
Abstract Traumatic wounds are the prevalent scenarios encountered in battleground and emergency rooms. The rapid effective hemostasis is imperative for life saving these scenarios, which development of high-efficiency biocompatible hemostatic materials essential. Due to its excellent property biocompatibility, collagen has emerged as an ideal component materials. Furthermore, properties collagen-based could be improved by integration other biomacromolecules, such alginate, cellulose derivatives, chitosan derivatives. Therefore, more novel with exceptional have been developed. This review aims overview recent progress Firstly, mechanism was introduced. Secondly, various forms materials, hydrogels, sponges, powders, were highlighted. Thirdly, composite biomacromolecules overviewed. Finally, outlook discussed. Graphical abstract
Язык: Английский
Процитировано
0
Polymers, Год журнала: 2024, Номер 16(14), С. 2047 - 2047
Опубликована: Июль 18, 2024
A hemostatic sponge prototype was successfully synthesized from fish gelatin as an alternative to mammalian gelatin; it mixed with alginate in certain combinations, double cross-linked calcium ions, and gamma irradiated at a dose of 20 kGy improve the characteristics effectiveness its function local agent. There were improvements physicochemical mechanical properties, porosity index, absorption capacity, biodegradation biocompatibility, hemocompatibility gelatin–alginate (FGAS) prototypes compared pure sponge. Hemostatic activity tests showed that means for clotting time, prothrombin activated partial thromboplastin time shorter FGAS than negative control, there no significant difference commercial The mechanism combined passive concentrator factor active through release ions coagulation cascade process.
Язык: Английский
Процитировано
2
Опубликована: Май 14, 2024
A hemostatic sponge prototype was successfully synthesized from fish gelatin as an alternative to mammalian gelatin, which mixed with alginate in certain combinations and double cross-linking of calcium ions gamma irradiation at a dose 20 kGy improve the characteristics effectiveness its function local agent. There improvement physicochemical mechanical properties, porosity index, absorption capacity, biodegradation biocompatibility, hemocompatibility FGAS prototypes compared pure sponge. Hemostatic activity tests showed that means clotting time, prothrombin activated partial thromboplastin time were shorter than negative control, there no significant difference commercial The mechanism combined passive concentrator factor active through release coagulation cascade process.
Язык: Английский
Процитировано
1
Biomaterials Science, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Modulation of collagen fibrillogenesis by varying the degrees chitosan deacetylation for preparation co-assembled biomimetic fibrils to enhance hemostasis.
Язык: Английский
Процитировано
1