Biomedical Technology, Год журнала: 2024, Номер 9, С. 100068 - 100068
Опубликована: Дек. 25, 2024
Язык: Английский
Journal of Cleaner Production, Год журнала: 2024, Номер 472, С. 143490 - 143490
Опубликована: Авг. 26, 2024
Язык: Английский
Процитировано
4
Journal of Biomedical Materials Research Part B Applied Biomaterials, Год журнала: 2025, Номер 113(2)
Опубликована: Янв. 22, 2025
ABSTRACT Intervertebral disc degeneration (IDD) is one of the leading causes chronic pain and disability, traditional treatment methods often struggle to restore its complex biomechanical properties. This article explores innovative application self‐healing hydrogels in IDD, offering new hope for repair due their exceptional self‐repair capabilities adaptability. As a key support structure human body, intervertebral discs are damaged by trauma or degenerative changes. Self‐healing not only mimic mechanical properties natural but also when damaged, thereby maintaining stable functionality. reviews mechanisms design strategies and, first time, outlines potential IDD. Furthermore, looks forward future developments field, including intelligent material design, multifunctional integration, encapsulation release bioactive molecules, combinations with tissue engineering stem cell therapy, perspectives IDD treatment.
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2025, Номер 32, С. 101655 - 101655
Опубликована: Март 12, 2025
Intervertebral disc degeneration (IVDD) is increasingly prevalent in aging societies and poses a significant health challenge. Due to the limited blood supply disc, oral medications systemic treatments are often ineffective. Consequently, localized injection therapies, which deliver therapeutic agents directly degenerated have emerged as more efficient. Self-healing injectable hydrogels particularly promising due their potential for minimally invasive delivery, precise implantation, targeted drug release into hard-to-reach tissue sites, including those requiring prolonged healing. Their dynamic viscoelastic properties accurately replicate mechanical environment of natural nucleus pulposus, providing cells with an adaptive biomimetic microenvironment. This review will initially discuss anatomy pathophysiology intervertebral discs, current treatments, limitations. Subsequently, we conduct bibliometric analysis explore research hotspots trends applying hydrogel technology treat IVDD. It then features biomedical applications such drug, protein, gene engineering regenerative medicine. We construction mechanisms via physical interactions, chemical biological crosslinkers, selection biomaterials fabrication methods developing novel IVD engineering. The article concludes future perspectives on application this field.
Язык: Английский
Процитировано
0
Bone Research, Год журнала: 2025, Номер 13(1)
Опубликована: Март 12, 2025
Abstract Aging is a pivotal risk factor for intervertebral disc degeneration (IVDD) and chronic low back pain (LBP). The restoration of aging nucleus pulposus cells (NPCs) to youthful epigenetic state crucial IVDD treatment, but remains formidable challenge. Here, we proposed strategy partially reprogram reinstate epigenetics senescent NPCs by delivering plasmid carrier that expressed pluripotency-associated genes ( Oct4 , Klf4 Sox2 ) in Cavin2-modified exosomes (OKS@M-Exo) treatment alleviating LBP. functional OKS@M-Exo efficaciously alleviated senescence markers p16 INK4a p21 CIP1 p53 ), reduced DNA damage H4K20me3 expression, as well restored proliferation ability metabolic balance NPCs, validated through vitro experiments. In rat model IVDD, maintained height, hydration tissue structure, effectively ameliorated via decreasing the markers. Additionally, nociceptive behavior downregulated nociception markers, indicating its efficiency transcriptome sequencing analysis also demonstrated could decrease expression age-related pathways restore cell proliferation. Collectively, reprogramming may hold promise therapeutic platform treat IVDD.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142082 - 142082
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Materials Today Communications, Год журнала: 2025, Номер unknown, С. 112652 - 112652
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Cell and Developmental Biology, Год журнала: 2023, Номер 11
Опубликована: Дек. 7, 2023
Low back pain caused by disc herniation and spinal stenosis imposes an enormous medical burden on society due to its high prevalence refractory nature. This is mainly the long-term inflammation degradation of extracellular matrix in process intervertebral degeneration (IVDD), which manifests as loss water nucleus pulposus (NP) formation fibrous fissures. Biomaterial repair strategies involving hydrogels play important role treatment degeneration. Excellent biocompatibility, tunable mechanical properties, easy modification, injectability, ability encapsulate drugs, cells, genes, etc. make good candidates scaffolds cell/drug carriers for treating NP other aspects IVDD. review first briefly describes anatomy, pathology, current treatments IVDD, then introduces different types addresses "smart hydrogels". Finally, we discuss feasibility prospects using treat
Язык: Английский
Процитировано
10
Biomaterials Science, Год журнала: 2023, Номер 12(2), С. 308 - 329
Опубликована: Дек. 18, 2023
Bone defects are often difficult to treat due their complexity and specificity, therefore pose a serious threat human life health. Currently, the clinical treatment of bone is mainly surgical. However, this more harmful patients there potential risk rejection infection. Hydrogels have unique three-dimensional structure that can accommodate variety materials, including particles, polymers small molecules, making them ideal for treating defects. Therefore, emerging composite hydrogels considered one most promising candidates This review describes use different types hydrogel in We present basic concepts hydrogels, preparation techniques (including chemical physical crosslinking), requirements used In addition, numerous designs doped with materials (
Язык: Английский
Процитировано
10
AAPS PharmSciTech, Год журнала: 2024, Номер 25(6)
Опубликована: Июнь 25, 2024
Язык: Английский
Процитировано
3
Pharmaceutics, Год журнала: 2024, Номер 16(8), С. 979 - 979
Опубликована: Июль 24, 2024
Intervertebral disc degeneration (IVDD) stands as the foremost contributor to low back pain (LBP), imposing a substantial weight on world economy. Traditional treatment modalities encompass both conservative approaches and surgical interventions; however, former falls short in halting IVDD progression, while latter carries inherent risks. Hence, quest for an efficacious method reverse onset is paramount. Biomaterial delivery systems, exemplified by hydrogels, microspheres, microneedles, renowned their exceptional biocompatibility, biodegradability, biological efficacy, mechanical attributes, have found widespread application bone, cartilage, various tissue engineering endeavors. Consequently, IVD has emerged burgeoning field of interest. This paper succinctly introduces intervertebral (IVD) structure pathophysiology IVDD, meticulously classifies biomaterials repair, reviews recent advances field. Particularly, strengths weaknesses are emphasized, potential avenues future research suggested.
Язык: Английский
Процитировано
3