LIPUS activated piezoelectric pPLLA/SrSiO3 composite scaffold promotes osteochondral regeneration through P2RX1 mediated Ca2+ signaling pathway

Biomaterials, Год журнала: 2025, Номер 317, С. 123084 - 123084

Опубликована: Янв. 2, 2025

Язык: Английский

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Bioactive Inorganic Materials for Innervated Multi‐Tissue Regeneration

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 27, 2025

Tissue engineering aims to repair damaged tissues with physiological functions recovery. Although several therapeutic strategies are there for tissue regeneration, the functional recovery of regenerated still poses significant challenges due lack concerns innervation. Design rationale multifunctional biomaterials both tissue-induction and neural induction activities shows great potential regeneration. Recently, research application inorganic attracts increasing attention in innervated multi-tissue such as central nerves, bone, skin, because its superior tunable chemical composition, topographical structures, physiochemical properties. More importantly, easily combined other organic materials, biological factors, external stimuli enhance their effects. This review presents a comprehensive overview recent advancements It begins introducing classification properties typical design inorganic-based material composites. Then, progresses regenerating various nerves nerve-innervated systematically reviewed. Finally, existing future perspectives proposed. may pave way direction offers new strategy regeneration combination

Язык: Английский

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A New Strategy to Inhibit Scar Formation by Accelerating Normal Healing Using Silicate Bioactive Materials

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Сен. 28, 2024

Abstract Inspired by the scar‐free wound healing in infants, an anti‐scar strategy is proposed accelerating using silicate bioactive materials. Bioglass/alginate composite hydrogels are applied, which significantly inhibit scar formation rabbit ear models. The underlining mechanisms include stimulation of Integrin Subunit Alpha 2 expression dermal fibroblasts to accelerate healing, and induction apoptosis hypertrophic directly stimulating N‐Acylsphingosine Amidohydrolase fibroblasts, indirectly upregulating secretion Cathepsin K fibroblasts. Considering specific functions materials, two treatment regimes tested. For severe scars, a regenerative intervention applied surgical removal followed with reduce scars activating mild dressing on formed reduces inducing apoptosis.

Язык: Английский

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Biodegradable copper-containing mesoporous microspheres loaded with ginsenoside Rb1 for infarcted heart repair

Biomaterials Advances, Год журнала: 2025, Номер 169, С. 214172 - 214172

Опубликована: Янв. 2, 2025

Язык: Английский

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The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical Practice

Biomedicines, Год журнала: 2025, Номер 13(3), С. 562 - 562

Опубликована: Фев. 24, 2025

Background/Objectives. Chronic wounds pose a substantial global healthcare burden exacerbated by aging populations and the increasing prevalence of conditions such as diabetes, peripheral vascular disease, venous insufficiency. Impaired physiological repair mechanisms, including angiogenesis, collagen synthesis, re-epithelialization, hinder healing process in chronic wounds. Many these processes are dependent on their interaction with copper. We hypothesized that targeted delivery copper ions to wound bed would enhance healing. Methods. Wound dressings impregnated oxide microparticles were designed ensure controlled release ions. The efficacy was evaluated using non-infected models, diabetic mouse models compared against control silver dressings. Outcome measures included closure rates, epidermal skin quality assessed histopathological examination, gene expression profiling. Clinical applications through diverse case studies trials involving management. Results. Copper significantly accelerated enhanced angiogenesis Histopathological analyses revealed faster granulation tissue formation, regeneration, neovascularization. Gene showed upregulation critical angiogenic factors VEGF HIF-1α. Investigations clinical observations corroborated improved across various types, Conclusions. is essential for healing, copper-impregnated provide promising solution By enhancing go beyond antimicrobial action, offering cost-effective innovative alternative conventional therapies. represent transformative advancement addressing challenges care.

Язык: Английский

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Silicified curcumin microspheres Combats cardiovascular diseases via Nrf2/HO-1 pathway

Bioactive Materials, Год журнала: 2025, Номер 49, С. 378 - 398

Опубликована: Март 15, 2025

Язык: Английский

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Integrated anti-inflammatory and anti-fibrosis dual drug-loaded core-shell fiber scaffolds: Diabetic wound healing and scar reduction

Journal of Material Science and Technology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Flexible Amorphous Silicon Radial Junction Patches Promote Skin Regeneration by Offering Wireless Photoelectric Neuromodulation

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Май 15, 2025

Photoelectric stimulation offers a promising method for creating noninvasive and durable interfaces with biological tissues, particularly in treating nerve injuries. However, developing flexible high-performance photoelectric stimulators remains challenge. In this study, we present an accessible cost-effective strategy fabricating ultraflexible biocompatible patch designed wireless, light-induced electrical to promote repair skin wounds. Using low-temperature chemical vapor deposition, created films based on three-dimensional (3D) amorphous silicon radial p-i-n junction (RJ) nanowires, which exhibit high open-circuit voltage of 0.79 V short-circuit current 10.5 mA/cm2 under standard AM 1.5 G illumination conditions. The device exhibits good electrochemical performance solution, featuring interfacial capacitance efficient photocurrent generation (∼0.64 mA/cm2), ensures stable, capacitive charge injection crucial effective bioelectrical stimulation. Importantly, the free-standing RJ can be reliably transferred onto soft poly(dimethylsiloxane) substrates produce patches that maintain intimate contact curved tissue surfaces. show biocompatibility effectively enhance neurite outgrowth wound healing safe visible light, promoting both vascular regeneration neural restoration. This holds potential wireless stimulation, providing robust solution comprehensive functional regeneration.

Язык: Английский

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3D-printed titanium dioxide-reinforced calcium silicate composite scaffold promotes efficient bone defect repair through activation of osteogenic and angiogenic differentiation

Materials & Design, Год журнала: 2025, Номер unknown, С. 114166 - 114166

Опубликована: Май 1, 2025

Язык: Английский

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Novel asymmetrical double-layer structural adhesive hydrogels with synergetic neuroprotection and angiogenesis effect for diabetic wound healing

Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 159081 - 159081

Опубликована: Дек. 1, 2024

Язык: Английский

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