Novel asymmetrical double-layer structural adhesive hydrogels with synergetic neuroprotection and angiogenesis effect for diabetic wound healing DOI

Zhihong Su,

Wanjun Zhang, Zhiqing Mo

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 159081 - 159081

Published: Dec. 1, 2024

Language: Английский

LIPUS activated piezoelectric pPLLA/SrSiO3 composite scaffold promotes osteochondral regeneration through P2RX1 mediated Ca2+ signaling pathway DOI
Chengxiao Liu, Bin Yu, Zhaowenbin Zhang

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 317, P. 123084 - 123084

Published: Jan. 2, 2025

Language: Английский

Citations

2
Bioactive Inorganic Materials for Innervated Multi‐Tissue Regeneration DOI Creative Commons
Hongjian Zhang, Ziyi Zhao, Chengtie Wu

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Tissue engineering aims to repair damaged tissues with physiological functions recovery. Although several therapeutic strategies are there for tissue regeneration, the functional recovery of regenerated still poses significant challenges due lack concerns innervation. Design rationale multifunctional biomaterials both tissue-induction and neural induction activities shows great potential regeneration. Recently, research application inorganic attracts increasing attention in innervated multi-tissue such as central nerves, bone, skin, because its superior tunable chemical composition, topographical structures, physiochemical properties. More importantly, easily combined other organic materials, biological factors, external stimuli enhance their effects. This review presents a comprehensive overview recent advancements It begins introducing classification properties typical design inorganic-based material composites. Then, progresses regenerating various nerves nerve-innervated systematically reviewed. Finally, existing future perspectives proposed. may pave way direction offers new strategy regeneration combination

Language: Английский

Citations

1
Biodegradable copper-containing mesoporous microspheres loaded with ginsenoside Rb1 for infarcted heart repair DOI
Dongmin Chen, X. D. Sheng, Huili Li

et al.

Biomaterials Advances, Journal Year: 2025, Volume and Issue: 169, P. 214172 - 214172

Published: Jan. 2, 2025

Language: Английский

Citations

0
The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical Practice DOI Creative Commons
Gadi Borkow,

Eyal Melamed

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 562 - 562

Published: Feb. 24, 2025

Background/Objectives. Chronic wounds pose a substantial global healthcare burden exacerbated by aging populations and the increasing prevalence of conditions such as diabetes, peripheral vascular disease, venous insufficiency. Impaired physiological repair mechanisms, including angiogenesis, collagen synthesis, re-epithelialization, hinder healing process in chronic wounds. Many these processes are dependent on their interaction with copper. We hypothesized that targeted delivery copper ions to wound bed would enhance healing. Methods. Wound dressings impregnated oxide microparticles were designed ensure controlled release ions. The efficacy was evaluated using non-infected models, diabetic mouse models compared against control silver dressings. Outcome measures included closure rates, epidermal skin quality assessed histopathological examination, gene expression profiling. Clinical applications through diverse case studies trials involving management. Results. Copper significantly accelerated enhanced angiogenesis Histopathological analyses revealed faster granulation tissue formation, regeneration, neovascularization. Gene showed upregulation critical angiogenic factors VEGF HIF-1α. Investigations clinical observations corroborated improved across various types, Conclusions. is essential for healing, copper-impregnated provide promising solution By enhancing go beyond antimicrobial action, offering cost-effective innovative alternative conventional therapies. represent transformative advancement addressing challenges care.

Language: Английский

Citations

0
Silicified curcumin microspheres Combats cardiovascular diseases via Nrf2/HO-1 pathway DOI
Tianwang Guan,

Zhenxing Lu,

Rundong Tai

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 378 - 398

Published: March 15, 2025

Language: Английский

Citations

0
Integrated anti-inflammatory and anti-fibrosis dual drug-loaded core-shell fiber scaffolds: Diabetic wound healing and scar reduction DOI

Jing Wen,

Xue Luo, Huan Liu

et al.

Journal of Material Science and Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Flexible Amorphous Silicon Radial Junction Patches Promote Skin Regeneration by Offering Wireless Photoelectric Neuromodulation DOI
Shuyi Wang, Zongguang Liu, Chen Cheng

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: May 15, 2025

Photoelectric stimulation offers a promising method for creating noninvasive and durable interfaces with biological tissues, particularly in treating nerve injuries. However, developing flexible high-performance photoelectric stimulators remains challenge. In this study, we present an accessible cost-effective strategy fabricating ultraflexible biocompatible patch designed wireless, light-induced electrical to promote repair skin wounds. Using low-temperature chemical vapor deposition, created films based on three-dimensional (3D) amorphous silicon radial p-i-n junction (RJ) nanowires, which exhibit high open-circuit voltage of 0.79 V short-circuit current 10.5 mA/cm2 under standard AM 1.5 G illumination conditions. The device exhibits good electrochemical performance solution, featuring interfacial capacitance efficient photocurrent generation (∼0.64 mA/cm2), ensures stable, capacitive charge injection crucial effective bioelectrical stimulation. Importantly, the free-standing RJ can be reliably transferred onto soft poly(dimethylsiloxane) substrates produce patches that maintain intimate contact curved tissue surfaces. show biocompatibility effectively enhance neurite outgrowth wound healing safe visible light, promoting both vascular regeneration neural restoration. This holds potential wireless stimulation, providing robust solution comprehensive functional regeneration.

Language: Английский

Citations

0
3D-printed titanium dioxide-reinforced calcium silicate composite scaffold promotes efficient bone defect repair through activation of osteogenic and angiogenic differentiation DOI Creative Commons
Zhiqiang Huang, Xinyi Wang, Zhaowenbin Zhang

et al.

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 114166 - 114166

Published: May 1, 2025

Language: Английский

Citations

0
A New Strategy to Inhibit Scar Formation by Accelerating Normal Healing Using Silicate Bioactive Materials DOI Creative Commons
Zhaowenbin Zhang, Chen Fan, Q. N. Xu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 28, 2024

Abstract Inspired by the scar‐free wound healing in infants, an anti‐scar strategy is proposed accelerating using silicate bioactive materials. Bioglass/alginate composite hydrogels are applied, which significantly inhibit scar formation rabbit ear models. The underlining mechanisms include stimulation of Integrin Subunit Alpha 2 expression dermal fibroblasts to accelerate healing, and induction apoptosis hypertrophic directly stimulating N‐Acylsphingosine Amidohydrolase fibroblasts, indirectly upregulating secretion Cathepsin K fibroblasts. Considering specific functions materials, two treatment regimes tested. For severe scars, a regenerative intervention applied surgical removal followed with reduce scars activating mild dressing on formed reduces inducing apoptosis.

Language: Английский

Citations

3
Novel asymmetrical double-layer structural adhesive hydrogels with synergetic neuroprotection and angiogenesis effect for diabetic wound healing DOI

Zhihong Su,

Wanjun Zhang, Zhiqing Mo

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 159081 - 159081

Published: Dec. 1, 2024

Language: Английский

Citations

2