Enhancing Vaccine Efficacy and Stability: A Review of the Utilization of Nanoparticles in mRNA Vaccines
Biomolecules,
Год журнала:
2024,
Номер
14(8), С. 1036 - 1036
Опубликована: Авг. 20, 2024
The
development
of
vaccines
has
entered
a
new
era
with
the
advent
nanotechnology,
particularly
through
utilization
nanoparticles.
This
review
focuses
on
role
nanoparticles
in
enhancing
efficacy
and
stability
mRNA
vaccines.
Nanoparticles,
owing
to
their
unique
properties
such
as
high
surface
area,
tunable
size,
ability
be
functionalized,
have
emerged
powerful
tools
vaccine
development.
Specifically,
lipid
(LNPs)
revolutionized
delivery
by
protecting
fragile
molecules
facilitating
efficient
uptake
cells.
discusses
various
types
employed
formulations,
including
lipid-based,
polymer-based,
inorganic
nanoparticles,
highlighting
advantages
limitations.
Moreover,
it
explores
mechanisms
which
improve
immune
responses,
enhanced
antigen
presentation
prolonged
release
mRNA.
also
addresses
challenges
future
directions
nanoparticle-based
development,
emphasizing
need
for
further
research
optimize
formulations
broader
applications.
By
providing
an
in-depth
analysis
current
advancements
potential
vaccines,
this
aims
shed
light
critical
combating
infectious
diseases
improving
public
health
outcomes.
Язык: Английский
Nonviral targeted mRNA delivery: principles, progresses, and challenges
MedComm,
Год журнала:
2025,
Номер
6(1)
Опубликована: Янв. 1, 2025
Abstract
Messenger
RNA
(mRNA)
therapeutics
have
garnered
considerable
attention
due
to
their
remarkable
efficacy
in
the
treatment
of
various
diseases.
The
COVID‐19
mRNA
vaccine
and
RSV
been
approved
on
market.
Due
inherent
nuclease‐instability
negative
charge
mRNA,
delivery
systems
are
developed
protect
from
degradation
facilitate
its
crossing
cell
membrane
express
functional
proteins
or
peptides
cytoplasm.
However,
deficiency
transfection
efficiency
targeted
biological
distribution
still
major
challenges
for
systems.
In
this
review,
we
first
described
physiological
barriers
process
then
discussed
design
approach
recent
advances
with
an
emphasis
tissue/cell‐targeted
abilities.
Finally,
pointed
out
existing
future
directions
deep
insights
into
efficient
We
believe
that
a
high‐precision
system
can
greatly
improve
therapeutic
effects
bio‐safety
accelerate
clinical
transformations.
This
review
may
provide
new
direction
serve
as
useful
guide
researchers
who
looking
suitable
system.
Язык: Английский
Optimizing mRNA delivery: A microfluidic exploration of DOTMA vs. DOTAP lipid nanoparticles for GFP expression on human PBMCs and THP-1 cell line
International Journal of Pharmaceutics,
Год журнала:
2025,
Номер
672, С. 125324 - 125324
Опубликована: Фев. 7, 2025
Язык: Английский
High-throughput screening for optimizing adoptive T cell therapies
Experimental Hematology and Oncology,
Год журнала:
2024,
Номер
13(1)
Опубликована: Ноя. 13, 2024
Abstract
Adoptive
T
cell
therapy
is
a
pivotal
strategy
in
cancer
immunotherapy,
demonstrating
potent
clinical
efficacy.
However,
its
limited
durability
often
results
primary
resistance.
High-throughput
screening
technologies,
which
include
both
genetic
and
non-genetic
approaches,
facilitate
the
optimization
of
adoptive
therapies
by
enabling
selection
biologically
significant
targets
or
substances
from
extensive
libraries.
In
this
review,
we
examine
advancements
high-throughput
technologies
their
applications
therapies.
We
highlight
use
for
cells,
tumor
other
promising
combination
strategies,
elucidate
role
identifying
small
molecules
targeted
delivery
systems
relevant
to
therapies,
providing
guidance
future
research
applications.
Язык: Английский