Adhesive Micro-Liquid for Efficient Removal of Bacterial Biofilm Infection

Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101525 - 101525

Опубликована: Янв. 1, 2025

Язык: Английский

Microenvironment-responsive nanoparticles functionalized titanium implants mediate redox balance and immunomodulation for enhanced osseointegration

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101628 - 101628

Опубликована: Март 2, 2025

Various pathological conditions (e.g., diabetes, osteoporosis) are accompanied by persistent oxidative stress, which compromises the immune microenvironment and poses substantial challenges for osseointegration. Reactive oxygen species (ROS) play a "double-edged sword" role in bone tissue. Therefore, developing responsive biomaterials to maintain redox balance dynamically is crucial enhanced Herein, microenvironment-responsive coordination nanoparticles (C-Ca-SalB NPs) composed of salvianolic acid B (SalB), catechol-conjugated chitosan (CS-C), Ca2+ constructed further covalently immobilized onto titanium implant surfaces. The resulting implants achieve on-demand antioxidant immunomodulatory effects manner, thus facilitating regeneration under both normal conditions. Under physiological conditions, functionalized display modest properties without affecting balance, while C-Ca-SalB NPs remain relatively stable. However, modified enable rapid decomposition acidic displaying robust ROS-scavenging, anti-inflammatory, osteoinductive capacities, ultimately remodeling into regenerative one. Overall, smart with controlled bioactive agent release this study present comprehensive solution enhancing bone-implant integration, particularly challenging context stress.

Язык: Английский

Oral delivery of probiotic combined natural phenolic-metal framework with microencapsulation for prolonged intestinal retention and alleviation of inflammatory bowel disease

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162763 - 162763

Опубликована: Апрель 1, 2025

Язык: Английский