Oral delivery of probiotic combined natural phenolic-metal framework with microencapsulation for prolonged intestinal retention and alleviation of inflammatory bowel disease DOI

Mengna Zhao,

Longkai Mu,

Fangqin Xiang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162763 - 162763

Published: April 1, 2025

Language: Английский

Adhesive Micro-Liquid for Efficient Removal of Bacterial Biofilm Infection DOI Creative Commons

Ying Wang,

Zhi-Bang Li, Lingli Ji

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101525 - 101525

Published: Jan. 1, 2025

Language: Английский

Citations

0
Microenvironment-responsive nanoparticles functionalized titanium implants mediate redox balance and immunomodulation for enhanced osseointegration DOI Creative Commons
Wei Chen,

Yifei Pan,

Catherine Huihan Chu

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101628 - 101628

Published: March 2, 2025

Various pathological conditions (e.g., diabetes, osteoporosis) are accompanied by persistent oxidative stress, which compromises the immune microenvironment and poses substantial challenges for osseointegration. Reactive oxygen species (ROS) play a "double-edged sword" role in bone tissue. Therefore, developing responsive biomaterials to maintain redox balance dynamically is crucial enhanced Herein, microenvironment-responsive coordination nanoparticles (C-Ca-SalB NPs) composed of salvianolic acid B (SalB), catechol-conjugated chitosan (CS-C), Ca2+ constructed further covalently immobilized onto titanium implant surfaces. The resulting implants achieve on-demand antioxidant immunomodulatory effects manner, thus facilitating regeneration under both normal conditions. Under physiological conditions, functionalized display modest properties without affecting balance, while C-Ca-SalB NPs remain relatively stable. However, modified enable rapid decomposition acidic displaying robust ROS-scavenging, anti-inflammatory, osteoinductive capacities, ultimately remodeling into regenerative one. Overall, smart with controlled bioactive agent release this study present comprehensive solution enhancing bone-implant integration, particularly challenging context stress.

Language: Английский

Citations

0
Oral delivery of probiotic combined natural phenolic-metal framework with microencapsulation for prolonged intestinal retention and alleviation of inflammatory bowel disease DOI

Mengna Zhao,

Longkai Mu,

Fangqin Xiang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162763 - 162763

Published: April 1, 2025

Language: Английский

Citations

0