Membrane Encapsulated Fe3O4@MnO@cGAMP Nanocatalyst for Cancer Therapy: cGAS‐STING Immune Pathway Activation DOI
Hua Chai, Renpeng Xia,

Nan Ouyang

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Abstract Reactive oxygen species (ROS) mediated cell damage is one of the most popular and effective ways for cancer therapy. However, overexpressed antioxidant reduced glutathione (GSH) always activated in tumor cells, which maintains redox equilibrium. Attempts to deplete GSH elevate ROS levels can be potent therapeutic strategies. Herein, membrane‐encapsulated Fe 3 O 4 @MnO 2′,3′‐cyclic GMP‐AMP (cGAMP) are prepared as nanocatalyst The ionized 3+ /Fe 2+ couple utilized initiate Fenton reaction. Intracellular level thus efficaciously controlled, peroxide oxidation catalyzed produce excessive ROS. Meanwhile, cGAMP released trigger cyclic synthase (cGAS)‐stimulator interferon genes (STING) signaling axis. This targeted activation enhances recruitment macrophages, stimulates secretion critical pro‐inflammatory cytokines, consequently bolsters efficacy innate immune responses within microenvironment.

Язык: Английский

Effect of tranexamic acid-functionalized photothermal hydrothermal treated oxidized graphene sponge on diabetic wound healing: Hemostasis, antibacterial, and regeneration DOI Creative Commons

Chaoyang Huang,

L. Chen,

Xiaoyang Liu

и другие.

Materials & Design, Год журнала: 2025, Номер unknown, С. 113915 - 113915

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Membrane Encapsulated Fe3O4@MnO@cGAMP Nanocatalyst for Cancer Therapy: cGAS‐STING Immune Pathway Activation DOI
Hua Chai, Renpeng Xia,

Nan Ouyang

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Abstract Reactive oxygen species (ROS) mediated cell damage is one of the most popular and effective ways for cancer therapy. However, overexpressed antioxidant reduced glutathione (GSH) always activated in tumor cells, which maintains redox equilibrium. Attempts to deplete GSH elevate ROS levels can be potent therapeutic strategies. Herein, membrane‐encapsulated Fe 3 O 4 @MnO 2′,3′‐cyclic GMP‐AMP (cGAMP) are prepared as nanocatalyst The ionized 3+ /Fe 2+ couple utilized initiate Fenton reaction. Intracellular level thus efficaciously controlled, peroxide oxidation catalyzed produce excessive ROS. Meanwhile, cGAMP released trigger cyclic synthase (cGAS)‐stimulator interferon genes (STING) signaling axis. This targeted activation enhances recruitment macrophages, stimulates secretion critical pro‐inflammatory cytokines, consequently bolsters efficacy innate immune responses within microenvironment.

Язык: Английский

Процитировано

0