Membrane Encapsulated Fe3O4@MnO@cGAMP Nanocatalyst for Cancer Therapy: cGAS‐STING Immune Pathway Activation DOI
Hua Chai, Renpeng Xia,

Nan Ouyang

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Abstract Reactive oxygen species (ROS) mediated cell damage is one of the most popular and effective ways for cancer therapy. However, overexpressed antioxidant reduced glutathione (GSH) always activated in tumor cells, which maintains redox equilibrium. Attempts to deplete GSH elevate ROS levels can be potent therapeutic strategies. Herein, membrane‐encapsulated Fe 3 O 4 @MnO 2′,3′‐cyclic GMP‐AMP (cGAMP) are prepared as nanocatalyst The ionized 3+ /Fe 2+ couple utilized initiate Fenton reaction. Intracellular level thus efficaciously controlled, peroxide oxidation catalyzed produce excessive ROS. Meanwhile, cGAMP released trigger cyclic synthase (cGAS)‐stimulator interferon genes (STING) signaling axis. This targeted activation enhances recruitment macrophages, stimulates secretion critical pro‐inflammatory cytokines, consequently bolsters efficacy innate immune responses within microenvironment.

Language: Английский

Effect of tranexamic acid-functionalized photothermal hydrothermal treated oxidized graphene sponge on diabetic wound healing: Hemostasis, antibacterial, and regeneration DOI Creative Commons

Chaoyang Huang,

L. Chen,

Xiaoyang Liu

et al.

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113915 - 113915

Published: April 1, 2025

Language: Английский

Citations

0
Membrane Encapsulated Fe3O4@MnO@cGAMP Nanocatalyst for Cancer Therapy: cGAS‐STING Immune Pathway Activation DOI
Hua Chai, Renpeng Xia,

Nan Ouyang

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Abstract Reactive oxygen species (ROS) mediated cell damage is one of the most popular and effective ways for cancer therapy. However, overexpressed antioxidant reduced glutathione (GSH) always activated in tumor cells, which maintains redox equilibrium. Attempts to deplete GSH elevate ROS levels can be potent therapeutic strategies. Herein, membrane‐encapsulated Fe 3 O 4 @MnO 2′,3′‐cyclic GMP‐AMP (cGAMP) are prepared as nanocatalyst The ionized 3+ /Fe 2+ couple utilized initiate Fenton reaction. Intracellular level thus efficaciously controlled, peroxide oxidation catalyzed produce excessive ROS. Meanwhile, cGAMP released trigger cyclic synthase (cGAS)‐stimulator interferon genes (STING) signaling axis. This targeted activation enhances recruitment macrophages, stimulates secretion critical pro‐inflammatory cytokines, consequently bolsters efficacy innate immune responses within microenvironment.

Language: Английский

Citations

0