Applications of Graphene in Five Senses, Nervous System, and Artificial Muscles

ACS Sensors, Год журнала: 2023, Номер 8(2), С. 482 - 514

Опубликована: Янв. 19, 2023

Graphene remains of great interest in biomedical applications because biocompatibility. Diseases relating to human senses interfere with life satisfaction and happiness. Therefore, the restoration by artificial organs or sensory devices may bring a bright future recovery patients. In this review, we update most recent progress graphene based sensors for mimicking such as retina image sensors, eardrums, gas chemical tactile sensors. The brain-like processors are discussed on conventional transistors well memristor related neuromorphic computing. brain–machine interface is introduced providing single pathway. Besides, muscles summarized means actuators order react physical world. Future opportunities remain elevating performances human-like their clinical applications.

Язык: Английский

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Graphene quantum dots for biosensing and bioimaging

RSC Advances, Год журнала: 2024, Номер 14(23), С. 16001 - 16023

Опубликована: Янв. 1, 2024

This review covers recent advancements in the synthesis of graphene quantum dots (GQDs) and their properties. It highlights GQDs' applications bioimaging for tumor visualization MRI, as well various biosensing technologies.

Язык: Английский

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Graphene quantum dot-crafted nanocomposites: shaping the future landscape of biomedical advances

Discover Nano, Год журнала: 2024, Номер 19(1)

Опубликована: Май 2, 2024

Graphene quantum dots (GQDs) are a newly developed class of material, known as zero-dimensional nanomaterials, with characteristics derived from both carbon (CDs) and graphene. GQDs exhibit several ideal properties, including the potential to absorb incident energy, high water solubility, tunable photoluminescence, good stability, drug-loading capacity, notable biocompatibility, which make them powerful tools for various applications in field biomedicine. Additionally, can be incorporated additional materials develop nanocomposites exceptional qualities enriched functionalities. Inspired by intriguing scientific discoveries substantial contributions biomedicine, we present broad overview recent advancements GQDs-based biomedical applications. The review first outlines latest synthesis classification nanocomposite enables their use advanced composite Furthermore, systematic study drug delivery, biosensing, photothermal, photodynamic combination therapies emphasized. Finally, possibilities, challenges, paths highlighted encourage research, will lead new therapeutics global healthcare improvements.

Язык: Английский

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A review of antibody, aptamer, and nanomaterials synergistic systems for an amplified electrochemical signal

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12

Опубликована: Март 13, 2024

The synergy between biomolecules with inorganic nanomaterials and nanoparticles has been investigated over the past years, primarily to improve biomarker reception, generate signals, amplify signals generated. In this paper, several articles on aptamer-based antibody-based electrochemical biosensors that target antigens were examined. Among key characteristics identified platform development, which includes usage of as electroactive or electrocatalytic labels, crosslinking biological agent compounds, electrode coating provide an electronic source support efficient electron transfer. A single approach using labeled unlabeled receptors become advantageous due its simple architecture more straightforward application method. However, dual system allows incorporation boost signal add features system. uses a capture reporter probe in competitive sandwich detection format. is often by compound immobilized nanocarrier, resulting increase measured peak current proportion target’s concentration. reported limit linear range for each presented assess efficiency. Generally, aptasensor showed higher sensitivity, stability, reproducibility than immunosensor comparable settings. promising results development point-of-care type applications.

Язык: Английский

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Photothermal therapy using graphene quantum dots

APL Bioengineering, Год журнала: 2023, Номер 7(3)

Опубликована: Авг. 21, 2023

The rapid development of powerful anti-oncology medicines have been possible because advances in nanomedicine. Photothermal therapy (PTT) is a type treatment wherein nanomaterials absorb the laser energy and convert it into localized heat, thereby causing apoptosis tumor eradication. PTT more precise, less hazardous, easy-to-control comparison to other interventions such as chemotherapy, photodynamic therapy, radiation therapy. Over past decade, various for applications reviewed; however, comprehensive study graphene quantum dots (GQDs) has scantly reported. GQDs received huge attention healthcare technologies owing their excellent properties, high water solubility, chemical stability, good biocompatibility, low toxicity. Motivated by fascinating scientific discoveries promising contributions field biomedicine, we present overview recent progress PTT. This review summarizes properties synthesis strategies including top-down bottom-up approaches followed (alone combination with modalities immunotherapy, radiotherapy). Furthermore, also focus on systematic vitro vivo toxicities triggered Moreover, an along synergetic application used eradication are discussed detail. Finally, directions, possibilities, limitations described encourage research, which will lead new treatments better health care bring people closer peak human well-being.

Язык: Английский

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Graphene Quantum Dots from Natural Carbon Sources for Drug and Gene Delivery in Cancer Treatment

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(19), С. 10539 - 10539

Опубликована: Сен. 30, 2024

Cancer therapy is constantly evolving, with a growing emphasis on targeted and efficient treatment options. In this context, graphene quantum dots (GQDs) have emerged as promising agents for precise drug gene delivery due to their unique attributes, such high surface area, photoluminescence, up-conversion biocompatibility. GQDs can damage cancer cells exhibit intrinsic photothermal conversion singlet oxygen generation efficiency under specific light irradiation, enhancing effectiveness. They serve direct therapeutic versatile platforms capable of being easily functionalized various targeting molecules agents. However, challenges achieving uniform size morphology, bandgap engineering, scalability, along minimizing cytotoxicity the environmental impact production, must be addressed. Additionally, there need more comprehensive understanding cellular mechanisms release processes, well improved purification methods. Integrating into existing systems enhances efficacy traditional treatments, offering less invasive options patients. This review highlights transformative potential in while acknowledging that researchers overcome broader application.

Язык: Английский

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Cancer Therapeutic siRNA Delivery and Imaging by Nitrogen- and Neodymium-Doped Graphene Quantum Dots

ACS Biomaterials Science & Engineering, Год журнала: 2023, Номер 9(6), С. 3425 - 3434

Опубликована: Май 31, 2023

While small interfering RNA (siRNA) technology has become a powerful tool that can enable cancer-specific gene therapy, its translation to the clinic is still hampered by inability of genes alone cell transfection, poor siRNA stability in blood, and lack delivery tracking capabilities. Recently, graphene quantum dots (GQDs) have emerged as novel platform allowing targeted drug fluorescence image visible near-infrared regions. These capabilities aid overcoming primary obstacles therapeutics. Here, for first time, we utilize biocompatible nitrogen- neodymium-doped (NGQDs Nd-NGQDs, respectively) Kirsten rat sarcoma virus (KRAS) epidermal growth factor receptor (EGFR) effective against variety cancer types. GQDs loaded with noncovalently facilitate successful transfection into HeLa cells, confirmed confocal microscopy at GQD concentrations 375 μg/mL. provides tracking, Nd doping enables deeper-tissue imaging suitable both

Язык: Английский

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Fluorinated graphene quantum dots with long-term lubrication for visual drug loading and joint inflammation therapy

Friction, Год журнала: 2023, Номер 11(12), С. 2204 - 2220

Опубликована: Март 31, 2023

Abstract Osteoarthritis (OA) treatment mainly relies on developing new drugs or nanocarriers, while little attention is paid to building novel remedial mode and improving drug loading efficiency. This work reports an integrated nanosystem that not only realizes visual release, but also achieves enhanced lubrication effective joint inflammation therapy based fluorinated graphene quantum dots (FGQDs). Oxygen introduction promotes FGQDs outstanding water-stability for months, layered nano-sized structure further guarantees excellent lubricating properties in biomimetic synovial fluid. The special design of chemistry endows robust fluorescence a wide range pH conditions. Also, the excitation spectrum well overlaps absorption drugs, which constructs concept internal filtering system visually monitor by naked eyes. More importantly, extraordinary long-term performance reported, first experimental demonstration concentration-dependent mutations coefficient friction (COF). Cell incubation experiments indicate drug-loaded have good biocompatibility, tracking property cellular uptake show efficient anti-inflammation potential H 2 O -induced chondrocyte degradation up-regulated cartilage anabolic genes. study establishes promising OA strategy enables enhance long-time property, anti-inflammatory protection.

Язык: Английский

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Graphene quantum dots: A review on the effect of synthesis parameters and theranostic applications

Colloids and Surfaces B Biointerfaces, Год журнала: 2022, Номер 217, С. 112605 - 112605

Опубликована: Май 30, 2022

Язык: Английский

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Dual-Mode Fluorescence/Ultrasound Imaging with Biocompatible Metal-Doped Graphene Quantum Dots

ACS Biomaterials Science & Engineering, Год журнала: 2022, Номер 8(11), С. 4965 - 4975

Опубликована: Сен. 30, 2022

Sonography offers many advantages over standard methods of diagnostic imaging due to its non-invasiveness, substantial tissue penetration depth, and low cost. The benefits ultrasound call for the development ultrasound-trackable drug delivery vehicles that can address a variety therapeutic targets. One disadvantage technique is lack high-precision imaging, which be circumvented by complementing contrast agents with visible and, especially, near-infrared (NIR) fluorophores. In this work, we, first time, develop lightly metal-doped (iron oxide, silver, thulium, neodymium, cerium chloride, molybdenum disulfide) nitrogen-containing graphene quantum dots (NGQDs) demonstrate high-contrast properties in brightness mode exhibit and/or fluorescence capabilities. NGQDs synthesized from glucosamine precursors only few percent metal doping do not introduce additional toxicity vitro, yielding 80% cell viability up 2 mg/mL doses. Their small (<50 nm) sizes warrant effective internalization, while oxygen-containing surface functional groups decorating their surfaces render water soluble allow attachment therapeutics targeting agents. Utilizing NIR fluorescence, we experience maximum accumulation within HEK-293 cells 6-12 h after treatment. successful 10-fold signal enhancement observed at 0.5-1.6 most vascular phantom, agarose gel, animal tissue. A combination non-invasive capabilities tracking makes these viable agent theragnostic applications.

Язык: Английский

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