Development and evaluation of hyaluronic acid-coated chitosan nanoparticles for improved delivery of sorafenib tosylate in the treatment of hepatocellular carcinoma

BioNanoScience, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 25, 2025

Язык: Английский

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Chitosan based niosomal hydrogel with polyethylene glycol and halloysite nanotubes for curcumin delivery

Journal of Molecular Liquids, Год журнала: 2024, Номер 401, С. 124640 - 124640

Опубликована: Апрель 2, 2024

The use of curcumin (Cur) as an anticancer drug is restricted due to its poor solubility and bioavailability. In this study, a pH-sensitive niosomal hydrogel composed halloysite nanotubes (HNTs), polyethylene glycol (PEG), chitosan (Cs) was developed for Cur delivery. Fourier transform infrared (FT-IR) spectroscopy X-ray diffraction (XRD) analyses confirmed the successful synthesis nanocomposite provided insights into interactions between components crystalline structure. Zeta potential analysis corroborated colloidal stability, scanning electron microscopy (SEM) images revealed spherical shape size in range 514–554 nm. homogeneous distribution by dynamic light scattering (DLS) experiments. Cs/PEG/HNTs nanocarrier showed high loading encapsulation efficiencies (44.2 % 84.0 %, respectively), well smart, release mechanism over 96-hour period, highlighting sustained targeted data were well-fitted Korsmeyer-Peppas Zero-Order models at pH 5.4 7.4, respectively. reduced survival U-87 MG human brain tumor cells presence Cs/PEG/HNTs@Cur samples compared Cs, Cs/PEG, Cs/PEG/HNTs, free corroborates anti-cancer properties. percentage late apoptotic higher than Cur, which attributed smart from Cs/PEG/HNTs@Cur. biocompatibility, biodegradability, ability effectively encapsulate regulate specifically target tumors makes designed highly versatile promising Cur-based cancer therapies.

Язык: Английский

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Recent advances on chitosan/hyaluronic acid-based stimuli-responsive hydrogels and composites for cancer treatment: A comprehensive review

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 135893 - 135893

Опубликована: Сен. 1, 2024

Язык: Английский

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Melphalan delivery and co-delivery nanoformulations for cancer therapy: A comprehensive review

European Journal of Medicinal Chemistry Reports, Год журнала: 2024, Номер 12, С. 100171 - 100171

Опубликована: Май 21, 2024

Regardless of the area or socio-economic status, cancer is currently second third prevalent cause mortality ahead stroke and coronary heart disease. Melphalan anticancer medication phenylalanine derivative nitrogen mustard has been demonstrated to successfully treat various types cancers by suppressing synthesis deoxyribonucleic acid. Moreover, melphalan shown exhibit synergetic effects in treatment multidrug-resistant tumors. However, its clinical application restricted since it comes with severe adverse significant drawbacks, such as non-target selectivity short plasma half-life. To circumvent these constraints, nanotechnological delivery platforms have designed recent years goal improving tumor sites regulating EPR effect. This review article provides an overview melphalan-based drug systems (DDS), which include polymeric, lipid-based, inorganic nanoformulations. The principal objective this paper discuss latest progress developed compare their essential factors particle size, size distribution, release profile, zeta potential, encapsulation loading efficiency, vitro vivo assessments. Additionally, different for co-delivery other drugs reviewed, provide promising future possibilities treatment. information summarized context will contribute developing a more practical approach

Язык: Английский

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Green Synthesis of pH-Sensitive Carboxymethyl Cellulose/Agarose/Carbon Quantum Dots Nanocarriers for Quercetin Delivery to A549 Lung Cancer Using an Emulsification Method

BioNanoScience, Год журнала: 2024, Номер unknown

Опубликована: Июнь 8, 2024

Язык: Английский

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Integration of molybdenum disulfide and phosphorene into polymeric-based nanocomposite hydrogels for various biomedical applications: Recent advances and future prospects

European Polymer Journal, Год журнала: 2024, Номер 218, С. 113347 - 113347

Опубликована: Июль 28, 2024

Язык: Английский

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Sodium alginate/chitosan composite scaffold reinforced with biodegradable polyesters/gelatin nanofibers for cartilage tissue engineering

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138054 - 138054

Опубликована: Ноя. 1, 2024

Язык: Английский

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Design, fabrication and biocompatibility assessment of a carbon cloth-integrated MoS2-CuS-GO thermoresponsive hydrogel microsystem for photothermal-triggered benvitimod delivery

Nano Materials Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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SynBioNanoDesign: pioneering targeted drug delivery with engineered nanomaterials

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 6, 2025

Synthetic biology and nanotechnology fusion represent a transformative approach promoting fundamental clinical biomedical science development. In SynBioNanoDesign, biological systems are reimagined as dynamic programmable materials to yield engineered nanomaterials with emerging specific functionalities. This review elucidates comprehensive examination of synthetic biology's pivotal role in advancing for targeted drug delivery systems. It begins exploring the synergy between nanotechnology, then highlights current landscape applications. Subsequently, discusses design novel informed by principles, focusing on expounding tools potential developing advanced nanomaterials. Afterward, research advances innovative through were systematically summarized, emphasizing integration genetic circuitry program nanomaterial responses. Furthermore, challenges, weaknesses opportunities, prospective directions, ethical societal implications SynBioNanoDesign elucidated. Finally, summarizes impact that may have drug-delivery technologies future.

Язык: Английский

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Addition of Ostrea rivularis polysaccharides in microneedle loaded with 3-acetylaconitine liposomes enhance analgesic activities and drug delivery properties

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 137064 - 137064

Опубликована: Окт. 1, 2024

Язык: Английский

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