Enhancing the Stability and Anticancer Activity of Escherichia coli Asparaginase Through Nanoparticle Immobilization: A Biotechnological Perspective on Nano Chitosan DOI Open Access
Fahad Alharthi,

Hussam A. Althagafi,

Ibrahim Jafri

и другие.

Polymers, Год журнала: 2024, Номер 16(23), С. 3260 - 3260

Опубликована: Ноя. 23, 2024

There is a shortage in the experimental research directly comparing effectiveness of different nanoparticles boosting asparaginase (ASNase) activity. This study assessed impact various on enhancing ASNase activity, stability, and anticancer effects through immobilization.

Язык: Английский

Development and evaluation of hyaluronic acid-coated chitosan nanoparticles for improved delivery of sorafenib tosylate in the treatment of hepatocellular carcinoma DOI
Putrevu Sreelaya, Sankha Bhattacharya, Darshan Bhirud

и другие.

BioNanoScience, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 25, 2025

Язык: Английский

Процитировано

2
Novel Polyethyleneimine-chitosan Nanoparticles Encapsulating Urolithin B: A Potential Nanotherapeutic Approach for Diabetic Nephropathy DOI

Jose Prakash Dharmian,

S. P. Angelin Claret,

P. Ramakrishnan

и другие.

Journal of Cluster Science, Год журнала: 2025, Номер 36(2)

Опубликована: Фев. 2, 2025

Язык: Английский

Процитировано

0
Chitosan/Sodium Tripolyphosphate Microemulsion Enhanced Oral Insulin Delivery via Intestinal Lymphoid DOI Open Access

Zhengpeng Zhong,

Fuping Wang,

Xue Gong

и другие.

Macromolecular Bioscience, Год журнала: 2025, Номер unknown

Опубликована: Фев. 27, 2025

Oral insulin delivery systems are currently being explored as the best alternative to subcutaneous injections, aiming overcome gastrointestinal barriers and achieve efficient oral delivery. This study presents a microemulsion system that utilizes chitosan/sodium tripolyphosphate (CS/STPP) enhance stability of kernel-loaded increase bioavailability via intestinal absorption lymphatic transport. The insulin/chitosan/sodium tripolyphosphate-microemulsion (Ins/CS/STPP-ME) is particle size (81.03 ± 7.19) nm polydispersity index (PDI) (0.313 0.013). Infrared spectroscopy confirms encapsulation. Ins/CS/STPP-ME exhibits favorable releasesproperties in fluids, retaining maximum (53.076 12.587)% pepsin environment (62.982 13.105)% trypsin after 60 min. In vivo studies have demonstrated addition CS/STPP internal phase results rapid onset action sustained hypoglycaemic effect diabetic rats. Lymphatic blockade by cycloheximide verified its ability cross gut enter bloodstream work demonstrates can stabilize proteins environment, facilitate absorption, bioavailability, provide longer-lasting hypoglycemic effects, thus providing possibility for biomacromolecule

Язык: Английский

Процитировано

0
Sustained release of nano-encapsulated glimepiride drug with chitosan nanoparticles: A novel approach to control type 2 diabetes in streptozotocin-induced Wistar albino rats DOI

Venkatesan Karthick,

Abdul Abduz Zahir, Singamoorthy Amalraj

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 287, С. 138496 - 138496

Опубликована: Дек. 6, 2024

Язык: Английский

Процитировано

1
Enhancing the Stability and Anticancer Activity of Escherichia coli Asparaginase Through Nanoparticle Immobilization: A Biotechnological Perspective on Nano Chitosan DOI Open Access
Fahad Alharthi,

Hussam A. Althagafi,

Ibrahim Jafri

и другие.

Polymers, Год журнала: 2024, Номер 16(23), С. 3260 - 3260

Опубликована: Ноя. 23, 2024

There is a shortage in the experimental research directly comparing effectiveness of different nanoparticles boosting asparaginase (ASNase) activity. This study assessed impact various on enhancing ASNase activity, stability, and anticancer effects through immobilization.

Язык: Английский

Процитировано

0