Composite microneedles loaded with Astragalus membranaceus polysaccharide nanoparticles promote wound healing by curbing the ROS/NF-κB pathway to regulate macrophage polarization

Carbohydrate Polymers, Год журнала: 2024, Номер 345, С. 122574 - 122574

Опубликована: Авг. 6, 2024

Язык: Английский

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Intelligent Electrospinning Nanofibrous Membranes for Monitoring and Promotion of Wound Healing

Materials Today Bio, Год журнала: 2024, Номер 26, С. 101093 - 101093

Опубликована: Май 18, 2024

The incidence of chronic wound healing is promoted by the growing trend elderly population, obesity, and type II diabetes. Although numerous dressings have been studied over years, it still challenging for many to perfectly adapt process due dynamic complicated microenvironment. Aiming at an optimal reproduction physiological environment, multifunctional electrospinning nanofibrous membranes (ENMs) emerged as a promising platform treatment owing their resemblance extracellular matrix (ECM), adjustable preparation processes, porousness, good conformability site. Moreover, profiting from booming development human-machine interaction artificial intelligence, next generation intelligent (iENMs) based dressing substrates that could realize real-time monitoring proceeding individual-based therapy has evoked surge interest. In this regard, general wound-related biomarkers are overviewed firstly representative iENMs stimuli-responsive materials briefly summarized. Subsequently, emergent applications highlighted. Finally, opportunities challenges next-generation well translating into clinical practice evaluated.

Язык: Английский

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Multifunctional Microneedle Patch Based on Metal-Phenolic Network with Photothermal Antimicrobial, ROS Scavenging, Immunomodulatory, and Angiogenesis for Programmed Treatment of Diabetic Wound Healing

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(26), С. 33205 - 33222

Опубликована: Июнь 25, 2024

In diabetic patients with skin injuries, bacterial proliferation, accumulation of reactive oxygen species (ROS) in the tissues, and impaired angiogenesis make wound healing difficult. Therefore, eliminating bacteria, removing ROS, promoting are necessary for treating acute wounds. this study, benefiting from ability polyphenols to form a metal-phenolic network (MPN) metal ions, TA-Eu MPN nanoparticles (TM NPs) were synthesized. The prepared photothermal agent CuS NPs TM then loaded onto supporting base needle tips PVA/HA (PH) microneedles, respectively, obtain PH/CuS/TM microneedles. Antibacterial experiments showed that microneedles could remove bacteria by effect. vitro effectively scavenge inhibit macrophage polarization M1 type, induce M2 type as well have promote vascular endothelial cell migration angiogenesis. Furthermore, vivo accelerated inhibiting pro-inflammatory cytokines rat model. efficient antibacterial, ROS scavenging, anti-inflammatory, immunomodulatory, angiogenic abilities hold promise dressings

Язык: Английский

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Forsythin-Loaded PET Membrane with Variable Wettability to Construct a Double-Layer Dressing for Wound Healing

ACS Applied Polymer Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 9, 2025

Язык: Английский

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Endogenous/exogenous stimuli‐responsive smart hydrogels for diabetic wound healing

Aggregate, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 6, 2024

Abstract Diabetes significantly impairs the body's wound‐healing capabilities, leading to chronic, infection‐prone wounds. These wounds are characterized by hyperglycemia, inflammation, hypoxia, variable pH levels, increased matrix metalloproteinase activity, oxidative stress, and bacterial colonization. complex conditions complicate effective wound management, prompting development of advanced diabetic care strategies that exploit specific characteristics such as acidic pH, high glucose stress trigger controlled drug release, thereby enhancing therapeutic effects dressings. Among solutions, hydrogels emerge promising due their stimuli‐responsive nature, making them highly for managing these The latest advancements in mono/multi‐stimuli‐responsive smart showcase superiority potential healthcare materials, highlighted relevant case studies. However, traditional dressings fall short meeting nuanced needs wounds, adjustable adhesion, easy removal, real‐time status monitoring, dynamic release adjustment according wound's conditions. Responsive represent a significant leap forward proficient sensing responding environment, offering more targeted approach treatment. This review highlights recent dressing, delivery, emphasizing role improving healing. It addresses ongoing challenges future directions, aiming guide clinical adoption.

Язык: Английский

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Polyaminoglycoside nanosystem expressing antimicrobial peptides for multistage chronic wound management

Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113657 - 113657

Опубликована: Март 1, 2025

Язык: Английский

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3D Electrospun nanofiber sponges of insect chitosan/pullulan/citric acid embedded with ZnMOF in situ for enhanced healing of MRSA-infected wounds

Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 155388 - 155388

Опубликована: Сен. 1, 2024

Язык: Английский

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Natural polymer nanofiber dressings for effective management of chronic diabetic wounds: A comprehensive review

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 136688 - 136688

Опубликована: Окт. 1, 2024

Язык: Английский

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Preparation and characterization of pH-responsive Janus composite membranes with unidirectional moisture drainage and antioxidant resistance

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2024, Номер 701, С. 134916 - 134916

Опубликована: Июль 24, 2024

Язык: Английский

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A pro-healing short-chain antimicrobial peptide that inhibits sepsis

Science China Materials, Год журнала: 2024, Номер unknown

Опубликована: Авг. 28, 2024

Язык: Английский

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