Clinical Cosmetic and Investigational Dermatology,
Год журнала:
2024,
Номер
Volume 17, С. 2417 - 2426
Опубликована: Окт. 1, 2024
Skin
photoaging,
resulting
from
prolonged
exposure
to
ultraviolet
(UV)
radiation,
is
characterized
by
intricate
biological
changes
involving
oxidative
damage
and
structural
alterations.
Despite
an
increasing
demand
for
effective
interventions,
the
current
therapeutic
options
treating
skin
photoaging
are
limited.
We
discovered
through
literature
data
search
on
PubMed
that
recent
research
has
shifted
its
focus
application
of
microneedle
patches
as
innovative
approach
address
this
concern.
Microneedle
patches,
serving
a
novel
transdermal
delivery
system,
exhibit
potential
deliver
bioactive
substances
such
cytokines,
cellular
vesicles,
gene
fragments
even
alive
algae
mitigate
effects
photoaging.
This
review
aims
provide
comprehensive
overview
advancements
in
about
utilizing
treatment
future
directions
leveraging
clinical
agents
rejuvenation.
Ultimately,
we
believe
have
broader
prospect
fields
medical
cosmetology
anti-photoaging.
Angewandte Chemie International Edition,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Abstract
Infectious
diseases
pose
considerable
challenges
to
public
health,
particularly
with
the
rise
of
multidrug‐resistant
pathogens
that
globally
cause
high
mortality
rates.
These
can
persist
on
surfaces
and
spread
in
healthcare
settings.
Advances
have
been
made
developing
antimicrobial
materials
reduce
transmission
pathogens,
including
composed
naturally
sourced
polyphenols
their
derivatives,
which
exhibit
potency,
broad‐spectrum
activity,
a
lower
likelihood
promoting
resistance.
This
review
provides
an
overview
recent
advances
fabrication
phenolic
biomaterials,
where
natural
compounds
act
as
active
agents
or
encapsulate
other
(e.g.,
metal
ions,
peptides,
biopolymers).
Various
forms
biomaterials
synthesized
through
these
two
strategies,
particles,
capsules,
hydrogels,
coatings,
are
summarized,
focus
application
wound
healing,
bone
repair
regeneration,
oral
coatings
for
medical
devices.
The
potential
advanced
promising
therapeutic
approach
combating
antimicrobial‐resistant
infections
reducing
microbial
transmission.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 14, 2025
Diabetic
wound
healing
remains
a
major
challenge
in
modern
medicine.
The
persistent
inflammation
and
immune
dysfunction
hinder
angiogenesis
by
producing
excessive
ROS
increasing
the
susceptibility
to
bacterial
infection.
In
this
study,
we
developed
an
integrated
strategy
for
whole-process
management
of
diabetic
wounds
based
on
bioinspired
adhesive
hydrogel
platform
with
hemostasis,
photothermal
antimicrobial,
antioxidant,
anti-inflammatory,
angiogenic
properties.
A
composite
(termed
AQTGF)
using
poly(acrylic
acid)
(PAA)
quaternized
chitosan
(QCS)
as
backbone
materials
loaded
TA-Gd/Fe-bimetallic-phenolic
coordination
polymer
was
prepared.
AQTGF
displayed
favorable
mechanical
properties,
self-healing
capabilities,
adhesion
characteristics,
response
performance.
vitro
experiments
demonstrated
that
exhibits
excellent
antimicrobial
capacity
angiogenic,
M2
macrophage
phenotype
polarizing
addition,
rat
tail
amputation
liver
hemostasis
had
Moreover,
vivo
studies
have
indicated
can
facilitate
accelerating
epidermal
growth,
promoting
collagen
deposition,
modulating
polarization,
inhibiting
inflammation,
angiogenesis.
conclusion,
study
provides
adaptable
holds
promise
treatment
chronic
wounds.
Abstract
Diabetic
wounds
present
a
significant
challenge
in
clinical
treatment
and
are
characterized
by
chronic
inflammation,
oxidative
stress,
impaired
angiogenesis,
peripheral
neuropathy,
heightened
risk
of
infection
during
the
healing
process.
By
creating
small
channels
surface
skin,
microneedle
technology
offers
minimally
invasive
efficient
approach
for
drug
delivery
treatment.
This
article
begins
outlining
biological
foundation
normal
skin
wound
unique
pathophysiological
mechanisms
diabetic
wounds.
It
then
delves
into
various
types,
materials,
preparation
processes
microneedles.
The
focus
is
on
application
multifunctional
microneedles
treatment,
highlighting
their
antibacterial,
anti-inflammatory,
immunomodulatory,
antioxidant,
angiogenic
neural
repair
properties.
These
demonstrate
synergistic
therapeutic
effects
directly
influencing
microenvironment,
ultimately
accelerating
advancement
not
only
holds
promise
enhancing
outcomes
but
also
new
strategies
addressing
other
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 27, 2025
Androgenetic
alopecia
(AGA),
a
chronic
and
progressive
disease,
significantly
impacts
the
patients'
social,
emotional,
mental
well-being.
Current
treatment
for
AGA
are
mainly
limited
by
drug
side
effects
stratum
corneum
(SC)
barrier
of
scalp.
To
address
these
issues,
we
developed
microneedle
(MN)
system
loaded
with
black
phosphorus
nanosheets
(BP)
encapsulating
baicalin
(BA),
natural
ingredient,
effective
AGA.
We
first
fabricated
BP-BA
based
on
BP
properties
high
loading
capacity
excellent
photothermal
conversion
efficiency.
Upon
635
nm
laser
irradiation,
demonstrated
efficient
to
mild
thermal
~
42
°C.
This
effect
controlled
BA's
stimuli-responsive
release,
enhanced
cellular
uptake,
effectively
modulated
gene
expression
in
dihydrotestosterone-treated
human
dermal
papilla
cells,
downregulating
negative
regulators
such
as
SRD5A2,
AR,
DKK1,
TGFB1,
while
upregulating
positive
like
CTNNBIP1
VEGFA.
Furthermore,
encapsulated
MN
fabricating
BP-BA@MNs
overcome
SC
barrier.
Compared
without
irradiation
penetration
into
subcutaneous
area
accumulation
at
follicular
site.
Importantly,
synergistic
efficacy
against
testosterone-induced
vivo
through
combining
BA
chemotherapy,
BP-mediated
therapy,
delivery,
well
good
biocompatibility
biosafety,
underlying
mechanism
was
elucidated
terms
microenvironment
reconstruction.
is
promising
approach
targeted
providing
multifunctional
strategy
addressing
clinical
needs
anti-AGA.
Polymers for Advanced Technologies,
Год журнала:
2024,
Номер
35(12)
Опубликована: Дек. 1, 2024
ABSTRACT
This
review
aims
to
provide
a
comprehensive
analysis
of
recent
advancements
in
smart
microneedles
(MNs)
within
the
biomedical
field,
focusing
on
integration
stimuli‐responsive
polymers
for
enhanced
therapeutic
and
diagnostic
applications.
Conventional
drug
delivery
methods
are
known
face
limitations
precision,
safety,
patient
compliance,
which
can
be
addressed
by
innovative
features
MNs.
Through
use
various
polymers,
these
MNs
have
been
designed
react
environmental
or
physiological
cues,
allowing
on‐demand
release,
biomarker
sensing,
localized
interventions.
Fundamental
materials
used
fabrication
MNs,
including
metals,
composite
hydrogels,
reviewed,
different
categories
stimuli‐responsiveness,
such
as
photo,
electro,
thermal,
mechanical,
biochemical,
explored.
Application‐specific
designs
areas
delivery,
cancer
therapy,
diabetes
management,
skin
disease
treatments
also
examined.
this
discussion,
it
is
highlighted
that
poised
play
significant
role
advancing
personalized
noninvasive
medical
treatments.
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(11), С. 7101 - 7132
Опубликована: Окт. 28, 2024
Chronic
wounds
are
a
major
healthcare
burden
and
may
severely
affect
the
social,
mental,
economic
status
of
patients.
Any
impairment
in
wound
healing
stages
due
to
underlying
factors
leads
prolonged
time
subsequently
chronic
wounds.
Traditional
approaches
for
treatment
include
dressing
free
local
therapy,
tissue
engineering
based
scaffold
therapies.
However,
traditional
therapies
need
improvisation
have
been
advanced
through
breakthrough
technologies.
The
present
review
spans
further
gives
an
extensive
account
advancements
Cutting
edge
technologies,
such
as
3D
printing,
which
includes
inkjet
fused
deposition
modeling,
digital
light
processing,
extrusion-based
microneedle
array-based
therapies,
gene
microRNAs
(miRNAs)
smart
dressings
real
monitoring
conditions
assessment
pH,
temperature,
oxygen,
moisture,
metabolites,
their
use
planning
better
strategies
discussed
detail.
future
direction
treatments
that
will
aid
lowering
caused
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(51), С. 70339 - 70351
Опубликована: Дек. 13, 2024
The
stratum
corneum
of
the
skin
functions
as
a
barrier,
obstructing
drug
absorption
and
complicating
treatment
infections
caused
by
pathogens
such
bacteria,
fungi,
viruses
through
topical
methods.
In
this
research,
microneedle
patch
was
developed,
which
consists
gelatin-sucrose
(SG)
that
encapsulates
polydopamine-copper
nanoparticles
(PDA@Cu)
at
tip
for
antibacterial
purposes.
Poly(ethylene
glycol)
diacrylate
(PEGDA)
served
primary
substrate
shaft
(PDA@Cu-SG/PEGDA).
This
engineered
to
enhance
permeability
facilitate
efficient
delivery
drugs
rapid
dissolution
tips.
Coordinate
bonds
can
be
formed
between
PDA
Cu
ions,
resulting
in
immobilization
particles
on
surface,
aids
green
synthesis
PDA@Cu
photothermal
particles.
SG
polymer,
contained
PDA@Cu,
employed
fill
cavities
series
centrifugation
steps.
Subsequently,
UV-induced
polymerization
carried
out
produce
PEGDA
microneedles
with
hydrophilic
tips
Furthermore,
physicochemical
characteristics
polymer
microneedles,
including
morphology,
composition,
mechanical
strength,
were
thoroughly
characterized.
These
demonstrated
sufficient
strength.
Owing
ability
disrupt
bacterial
membranes,
excellent
vitro
efficacy.
We
validated
activity
against
Escherichia
coli
Staphylococcus
aureus
conducting
plate
coating
assays.
results
assays
indicated
minimally
invasive
strategy
achieved
broad-spectrum
effects;
thus,
may
suitable
approach
managing
polymicrobial
during
clinical
trials.
