New Direction in Antimicrobial Delivery System: Preparation and Applications of Hydrogel Microspheres

Pharmaceutics, Год журнала: 2025, Номер 17(4), С. 529 - 529

Опубликована: Апрель 17, 2025

Antimicrobial delivery systems have undergone extensive development, yet conventional carriers still exhibit limitations such as low loading capacity, inadequate controlled release mechanisms, and cytotoxicity. Recent studies increasingly demonstrated the potential of Hydrogel Microspheres (HMSs) for antimicrobial delivery. These microspheres small dimensions, high drug-loading ability to achieve deep-targeted delivery, complemented by adjustable physicochemical properties biocompatibility that create favorable conditions transportation. This review systematically examines HMS preparation strategies, characteristic properties, transported antimicrobials, therapeutic applications. Particular emphasis is placed on critical parameters governing performance, especially those influencing drug dynamics. We conclude addressing current challenges proposing actionable strategies material optimization clinical translation. work aims advance HMS-based more effective infection control.

Язык: Английский

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An Overview on Recent Progress of Microsphere‐Hydrogel Combination Systems as Scaffolds for Tissue Engineering

ChemistrySelect, Год журнала: 2025, Номер 10(16)

Опубликована: Апрель 1, 2025

Abstract Tissue engineering aiming to develop and manufacture bioactive tissue or organ substitutes has been extensively studied. As an ideal scaffold material, the microsphere‐hydrogel combination system (MHCS), which combines excellent functionalities of hydrogels unique structural advantages microspheres, widely used in development biological for engineering. With adjustable mechanical properties, MHCS can simulate extracellular matrix‐like microstructure microenvironment conducive cell growth. These properties endow with repair, leading significant progress regeneration bone, skin, blood vessels, nerves, other tissues. In this paper, we reviewed latest construction based on natural polymers, synthetic inorganic materials, their composites. We also classified raw materials that were utilized microspheres discussed applications MHCS. Finally, challenges perspectives emphasized pointed out direction future development, such as conducted advanced processing technologies multidisciplinary cooperation solve limitations uneven microsphere distribution mismatched degradation rates, thus providing a reference design fabrication field

Язык: Английский

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Antiinflammatory and antibacterial polytetrahydropyrimidine loaded on degradable thermosensitive hydrogels for treatment of open wounds

Applied Materials Today, Год журнала: 2024, Номер 39, С. 102274 - 102274

Опубликована: Июнь 17, 2024

Язык: Английский

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Preparation of bacterial cellulose/acrylic acid-based pH-responsive smart dressings by graft copolymerization method

Journal of Biomaterials Science Polymer Edition, Год журнала: 2024, Номер 35(18), С. 2767 - 2789

Опубликована: Авг. 20, 2024

Conventional wound dressings used in trauma treatment have a single function and insufficient adaptability to the environment, making it difficult meet complex demands of healing process. Stimuli-responsive hydrogels can respond specifically particular environment area realize on-demand responsive release by loading active substances, which effectively promote healing. In this paper, BC/PAA-pH (BPPRHs) were prepared graft copolymerization acrylic acid (AA) end molecular chain bacterial cellulose (BC) network structure. Antibacterial pH-responsive 'smart' curcumin (Cur) onto hydrogels. Surface morphology, chemical groups, crystallinity, rheological, mechanical properties BPPRHs analyzed different characterization methods. The drug behavior under physiological conditions bacteriostatic BPPRH-Cur also investigated. results structural performance studies show that hydrogel has three-dimensional mesh structure pH capacity. environmental conformed logistic Weibull kinetic models. displayed good antimicrobial activity against common pathogens infections such as E. coli, S. aureus, P. aeruginosa destroying cell membrane lysing cells. This study lays foundation for development new pharmaceutical with positive health, economic social benefits.

Язык: Английский

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Glycyrrhizic acid and glycyrrhetinic acid loaded cyclodextrin MOFs with enhanced antibacterial and anti-inflammatory effects for accelerating diabetic wound healing

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 245, С. 114200 - 114200

Опубликована: Сен. 3, 2024

Язык: Английский

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