Defect‐Engineered Biomimetic Piezoelectric Nanocomposites With Enhanced ROS Production, Macrophage Re‐polarization, and Ca²⁺ Channel Activation for Therapy of MRSA‐Infected Wounds and Osteomyelitis

Small, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

Antibiotic-resistant bacteria often cause lethal infections in both the surficial and deep organs of humans. Failure antibiotics resistant leads to more effective alternative therapies, like spatiotemporally controllable piezodynamic therapy (PZDT) with penetration. Currently, PZDT demands further investigation for improved treatment outcomes corresponding therapeutic mechanisms. Herein, a nanocomposite cloaked is reported biomimetic coating TLR-upregulated macrophage membrane targeted against MRSA-induced skin wound infection osteomyelitis, representing models, respectively. To boost efficacy, crystal defect engineering applied by impregnating Fe2+ into bismuth oxy-iodide nanosheets increase defects. This results significantly higher piezoelectric coefficient than previous reports, contributing an amplified reactive oxygen species generation bacterial killing. More importantly, notable effect not only re-programs macrophages anti-inflammatory M2 phenotype accelerating healing but also stimulates opening piezo-stimulated Ca2+ channels boosts differentiation mesenchymal stem cells osteoblasts expediting bone tissue repair osteomyelitis model. Moreover, Fe-doping supplements T2-magnetic resonance imaging real-time visualization distribution. theranostic system opens new avenue future drug-resistant bacteria-caused diseases.

Язык: Английский

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Unveiling the Electrocatalytic Performances of the Pd-MoS2 Catalyst for Methanol-Mediated Overall Water Splitting

Inorganics, Год журнала: 2025, Номер 13(1), С. 21 - 21

Опубликована: Янв. 15, 2025

Herein, this work elucidates the synthesis of Pd-MoS2 catalyst for application in methanol-mediated overall water splitting. The scanning electron microscope (SEM) and transmission (TEM) pictures offer an exciting nanostructured shape Pd-MoS2, depicting a high surface area. Further, high-resolution TEM (HRTEM) confirm lattice plane (100), spacing (0.26 nm), hexagonal crystal structure Pd-MoS2. Moreover, high-angle annular dark-field (HAADF) images related color maps disclose Mo, S, Pd elements exhibits lower overpotentials 224.6 mV [methanol-mediated hydrogen evolution reaction (MM-HER)] at −10 mA cm−2 133 oxygen (MM-OER)] 10 cm−2. illustrates noteworthy stability 15.5 h MM-HER 18 MM-OER by chronopotentiometry test. Excitingly, Pd-MoS2∥Pd-MoS2 cell reveals small potential 1.581 V compared to MoS2∥MoS2 (1.648 V) In addition, combination brilliant durability over

Язык: Английский

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Hybrid Triboelectric Nanogenerators: Revolutionizing the Energy Harvesting through Material Diversity and Device Architecture for Different Applications

Nano Energy, Год журнала: 2024, Номер 131, С. 110253 - 110253

Опубликована: Сен. 10, 2024

Язык: Английский

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Flexible and Robust Piezoelectric Chitosan Films with Enhanced Bioactivity

Biomacromolecules, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Chitosan (CHT) is a known piezoelectric biomacromolecule; however, its usage limited due to rapid degradation in an aqueous system. Herein, we prepared CHT film via solvent casting method and cross-linked alkaline solution. Sodium hydroxide facilitated deprotonation, leading increased intramolecular hydrogen bonding mechanical properties. The remained intact for 30 days environments. A systematic study revealed gradual increase the output voltage from 0.9 1.8 V under external force (1-16 N). In addition, showed remarkable antibacterial anti-inflammatory activities ultrasound stimulation inhibition of inflammatory cytokines. films also displayed enhanced cellular proliferation ∼5-fold faster migration NIH3T3 cells US stimulation. Overall, this work presents robust, biocompatible, wearable device that can transform biomechanical energy into electrical pulses modulation cell fate processes other bioactivities.

Язык: Английский

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Recent advances in ultrasound-assisted CO2 absorption/desorption processes: A review

Process Safety and Environmental Protection, Год журнала: 2025, Номер unknown, С. 107050 - 107050

Опубликована: Март 1, 2025

Язык: Английский

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Emerging Piezoelectric Metamaterials for Biomedical Applications

Опубликована: Ноя. 21, 2024

Emerging piezoelectric metamaterials hold immense promise for biomedical applications by merging the intrinsic electrical properties of piezoelectricity with precise architecture metamaterials. This review provides a comprehensive overview various materials- such as molecular crystals, ceramics, and polymers-known their exceptional performance biocompatibility. We explore advanced engineering approaches, including design, supramolecular packing, 3D assembly, which enable customization targeted applications. Particular attention is given to pivotal role metamaterial structuring in development 0D spheres, 1D fibers tubes, 2D films, scaffolds. Key applications, tissue engineering, drug delivery, wound healing, biosensing, are discussed through illustrative examples. Finally, article addresses critical challenges future directions, aiming drive further innovations biomaterials next-generation healthcare technologies.

Язык: Английский

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Synergistic integration of electrical stimulation, reactive oxygen species regulation, and pro-angiogenic for accelerated wound healing

Nano Energy, Год журнала: 2024, Номер 131, С. 110200 - 110200

Опубликована: Сен. 3, 2024

Wound healing involves a complex series of coordinated events throughout the inflammatory, proliferative, and maturation phases tissue repair. Current treatment modalities lack device catering to all wound stages for recovery, angiogenesis epithelialization. Herein, we developed an integrated system with multiple functions self-electrical stimulation (ES), reactive oxygen species (ROS) regulation, bioactive metal-releasing patch (ERMP) address including hemostasis, inflammation, proliferation, remodeling. The ERMP are ES, generated by movement mice, regeneration, magnesium (Mg) ion release via iontophoresis triggered ES pro-angiogenic effects, simultaneous regulation ROS. This employs self-generating utilizing movements individuals trigger triboelectric nanogenerators (TENGs), which consequently transfer through Mg microneedles while effectively delivering enhanced ions site. Specially, Prussian blue (PB) was utilized not only enhance output performance on TENG as charge trap, but also regulate excessive ROS modified PB carbon–nitrogen vacancies in synergistic effects releases led nine-fold recovery rates compared control group vivo tests. approach addresses inherent limitations conventional methods provides viable various severe types.

Язык: Английский

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An advanced ultrasound-activated drug delivery system with piezocatalytic MoS2 nanoflowers for treating patent ductus arteriosus

Applied Materials Today, Год журнала: 2024, Номер 41, С. 102434 - 102434

Опубликована: Сен. 19, 2024

Язык: Английский

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High efficiency degradation of RhB by MIL-88A(Fe)/MoS2 activated persulfate and its mechanism

Journal of Solid State Chemistry, Год журнала: 2024, Номер 341, С. 125027 - 125027

Опубликована: Сен. 26, 2024

Язык: Английский

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