Biosynthetic small molecule antigens mimics medicated lateral flow immunoassay for mycotoxin Fumonisin B1 using nanobody fusion proteins

Journal of Hazardous Materials, Год журнала: 2025, Номер 487, С. 137194 - 137194

Опубликована: Янв. 11, 2025

Язык: Английский

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Multifunctional Hydrogel Microneedles (HMNs) in Drug Delivery and Diagnostics

Gels, Год журнала: 2025, Номер 11(3), С. 206 - 206

Опубликована: Март 15, 2025

Hydrogel microneedles (HMNs) have emerged as a transformative platform for minimally invasive drug delivery and biosensing, offering enhanced bioavailability, controlled release, real-time biomarker detection. By leveraging swelling hydrogels, nanomaterial integration, stimuli-responsive properties, HMNs provide precision medicine capabilities across diverse therapeutic diagnostic applications. However, challenges remain in mechanical stability, hydrogel-based MNs must balance flexibility with sufficient strength skin penetration. Drug retention release require optimization to prevent premature diffusion ensure sustained effects. Additionally, biosensing accuracy is influenced by variability interstitial fluid extraction signal transduction. Clinical translation hindered regulatory hurdles, scalability concerns, the need extensive safety validation human trials. This review critically examines key materials, fabrication techniques, functional testing frameworks of while addressing these limitations. Furthermore, we explore future research directions smart wearable MNs, AI-assisted hybrid drug–device platforms optimize transdermal medicine. Overcoming barriers will drive clinical adoption HMNs, paving way next-generation patient-centered therapeutics diagnostics.

Язык: Английский

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Innovative Nanozyme-Based Detection Methods for Biomarkers in Interstitial Fluid

TrAC Trends in Analytical Chemistry, Год журнала: 2025, Номер unknown, С. 118248 - 118248

Опубликована: Апрель 1, 2025

Язык: Английский

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Metal coordination bond and rough interface enhanced triboelectric nanogenerator aiming for multiple complex conditions

Nano Energy, Год журнала: 2024, Номер unknown, С. 110532 - 110532

Опубликована: Дек. 1, 2024

Язык: Английский

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