Nanoparticle-Based Sustainable Agriculture and Food Science: Recent Advances and Future Outlook

Frontiers in Nanotechnology, Год журнала: 2020, Номер 2

Опубликована: Дек. 4, 2020

In the current scenario, it is an urgent requirement to satisfy nutritional demands of rapidly growing global population. Using conventional farming, nearly one third crops get damaged, mainly due pest infestation, microbial attacks, natural disasters, poor soil quality, and lesser nutrient availability. More innovative technologies are immediately required overcome these issues. this regard, nanotechnology has contributed agrotechnological revolution that imminent potential reform resilient agricultural system while promising food security. Therefore, nanoparticles becoming a new-age material transform modern practices. The variety nanoparticle-based formulations, including nano-sized pesticides, herbicides, fungicides, fertilizers, sensors, have been widely investigated for plant health management improvement. In-depth understanding nanomaterial interactions opens new avenues toward improving crop practices through increased properties such as disease resistance, yield, utilization. review, we highlight critical points address nanotechnology-based research could benefit productivity security in future.

Язык: Английский

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Nanoenzyme-Reinforced Injectable Hydrogel for Healing Diabetic Wounds Infected with Multidrug Resistant Bacteria

Nano Letters, Год журнала: 2020, Номер 20(7), С. 5149 - 5158

Опубликована: Июнь 23, 2020

Diabetic wound healing remains a critical challenge due to its vulnerability multidrug-resistant (MDR) bacterial infection, as well the hyperglycemic and oxidative microenvironment. Herein, an injectable multifunctional hydrogel (FEMI) was developed simultaneously overcome these hurdles. The FEMI fabricated through Schiff-based reaction between ε-polylysine (EPL)-coated MnO2 nanosheets (EM) insulin-loaded self-assembled aldehyde Pluronic F127 (FCHO) micelles. Through synergistic combination of EPL "nanoknife-like" nanosheets, exhibited extraordinary antimicrobial capacities against MDR bacteria. nanoenzyme reshaped hostile microenvironment by decomposing endogenous H2O2 into O2. Meanwhile, pH/redox dual-responsive achieved sustained spatiotemporal controlled release insulin regulate blood glucose. Our demonstrated accelerated bacteria-infected diabetic in vivo represents versatile strategy for broad range tissue damages caused diabetes.

Язык: Английский

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Promoting the healing of infected diabetic wound by an anti-bacterial and nano-enzyme-containing hydrogel with inflammation-suppressing, ROS-scavenging, oxygen and nitric oxide-generating properties

Biomaterials, Год журнала: 2022, Номер 286, С. 121597 - 121597

Опубликована: Май 22, 2022

Язык: Английский

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Design of therapeutic biomaterials to control inflammation

Nature Reviews Materials, Год журнала: 2022, Номер 7(7), С. 557 - 574

Опубликована: Фев. 28, 2022

Язык: Английский

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Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

Journal of Hematology & Oncology, Год журнала: 2022, Номер 15(1)

Опубликована: Сен. 12, 2022

Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving therapeutic potential various agents and bioactive molecules through enhanced permeability retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective tumor cells utilizing cell surface-specific receptors, vasculature antigens high accuracy affinity. Additionally, stimuli-responsive nanoplatforms also been as a promising strategy against tumors, these maintain their stealth feature under conditions, but upon homing cancerous lesions or microenvironment, are responsive release cargoes. In this review, we comprehensively summarize field active number studies context emerging nanoplatform development, discuss how knowledge contribute further improvements clinical practice.

Язык: Английский

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Molecular Self-Assembly of Bioorthogonal Aptamer-Prodrug Conjugate Micelles for Hydrogen Peroxide and pH-Independent Cancer Chemodynamic Therapy

Journal of the American Chemical Society, Год журнала: 2019, Номер 142(2), С. 937 - 944

Опубликована: Дек. 20, 2019

Chemodynamic therapy (CDT) has demonstrated new possibilities for selective and logical cancer intervention by specific manipulation of dysregulated tumorous free radical homeostasis. Current CDT methods largely rely on conversion endogenous hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals via classical Fenton or Haber–Weiss chemistry. However, their anticancer efficacies are greatly limited the requirement strong acidity efficient chemical reactions, insufficient H2O2, upregulated antioxidant defense to counteract radical-caused oxidative damage. Here, we present a concept whereby bioorthogonal chemistry prodrug combined create type aptamer drug conjugate (ApDC): aptamer-prodrug (ApPdC) micelle improved cancer-targeted CDT. The hydrophobic bases can not only promote self-assembly aptamers but also act as generators In depth mechanistic studies reveal that, unlike traditional systems, ApPdC micelles enable in situ activation self-cycling generation C-centered cells through cascading with no dependence either H2O2 pH, yet concurrently diminished cancerous antioxidation GSH depletion synergistic effect. We expect this work provide insights design targeted therapies radical-related molecular mechanisms.

Язык: Английский

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Injectable redox and light responsive MnO2 hybrid hydrogel for simultaneous melanoma therapy and multidrug-resistant bacteria-infected wound healing

Biomaterials, Год журнала: 2020, Номер 260, С. 120314 - 120314

Опубликована: Авг. 12, 2020

Язык: Английский

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Microenvironment‐Based Diabetic Foot Ulcer Nanomedicine

Advanced Science, Год журнала: 2022, Номер 10(2)

Опубликована: Ноя. 24, 2022

Diabetic foot ulcers (DFU), one of the most serious complications diabetes, are essentially chronic, nonhealing wounds caused by diabetic neuropathy, vascular disease, and bacterial infection. Given its pathogenesis, DFU microenvironment is rather complicated characterized hyperglycemia, ischemia, hypoxia, hyperinflammation, persistent However, current clinical therapies for dissatisfactory, which drives researchers to turn attention advanced nanotechnology address therapeutic bottlenecks. In last decade, a large number multifunctional nanosystems based on have been developed with positive effects in therapy, forming novel concept "DFU nanomedicine". systematic overview nanomedicine still unavailable literature. This review summarizes microenvironmental characteristics DFU, presents main progress wound healing, summaries state-of-the-art strategies DFU. Furthermore, challenges future perspectives this field discussed prospected, aiming fuel foster development nanomedicines successfully.

Язык: Английский

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Mitochondria-targeted TPP-MoS2 with dual enzyme activity provides efficient neuroprotection through M1/M2 microglial polarization in an Alzheimer's disease model

Biomaterials, Год журнала: 2019, Номер 232, С. 119752 - 119752

Опубликована: Дек. 30, 2019

Язык: Английский

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Combined Antioxidant–Antibiotic Treatment for Effectively Healing Infected Diabetic Wounds Based on Polymer Vesicles

ACS Nano, Год журнала: 2021, Номер 15(5), С. 9027 - 9038

Опубликована: Апрель 21, 2021

Infected diabetic wounds are difficult to heal due high reactive oxygen species (ROS) concentrations and recurrent infections. Such can easily deteriorate into a ulcer, chronic complication with very mortality rate. Herein, we propose combined antioxidant-antibiotic therapy based on poly(ε-caprolactone)-block-poly(glutamic acid) polymer vesicle treat infected wounds. This was realized by in situ decoration of stable, well-dispersed ceria nanoparticles onto ciprofloxacin (CIP)-loaded vesicles. These resulting CIP-loaded ceria-decorated vesicles (CIP-Ceria-PVs) exhibited superoxide dismutase mimetic activity inhibit free radicals (the inhibition rate reached ∼50% at an extremely low cerium concentration 1.25 μg/mL). When the content is range 5-20 μg/mL, CIP-Ceria-PVs showed highest protective capability normal L02 cells from damage radicals. In addition, enhanced antibacterial dosage CIP reduced 25-50% compared CIP). vivo treatment performed mice model. The could effectively cure within 14 days. Overall, proposed introducing for

Язык: Английский

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