Colloids and Surfaces B Biointerfaces,
Год журнала:
2022,
Номер
221, С. 112950 - 112950
Опубликована: Окт. 20, 2022
Nanozymes
are
super-efficient
nanomaterials
with
enzyme-like
characteristics,
as
the
name
suggests.
In
last
decade,
efforts
have
been
made
to
develop
"artificial
enzymes,"
which
alternatives
natural
enzymes.
As
nanoscience
and
nanotechnology
advance,
nanozymes,
catalytic
having
properties,
fascinated
researchers'
attention.
unique
physicochemical
properties
that
mimic
activity
gained
a
special
interest
in
industrial
sectors.
However,
several
constraints
hampered
their
effective
deployment
processes,
including
denaturation,
time-consuming
manufacturing,
overall
high
cost-ratio,
reutilization
challenges.
After
brief
overview
of
nanozyme
research,
an
analysis
similarities
differences
between
nanozymes
synthetic
enzymes
is
presented.
Because
distinct
stand
out
this
comparison.
exhibited
variety
applications
leveraging
physiochemical
nanomaterials,
ranging
from
vitro
detection
enzyme
substitution
biological
systems.
addition,
introduced
new
field
called
nanozymology,
blends
enzymology.
Advanced Materials,
Год журнала:
2023,
Номер
36(10)
Опубликована: Апрель 22, 2023
Nanozymes
have
great
potential
to
be
used
as
an
alternative
natural
enzymes
in
a
variety
of
fields.
However,
low
catalytic
activity
compared
with
limits
their
practical
use.
It
is
still
challenging
design
nanozymes
comparable
counterparts
terms
the
specific
activity.
In
this
study,
surface
engineering
strategy
employed
improve
Ru
using
charge-transferrable
ligands
such
polystyrene
sulfonate
(PSS).
PSS-modified
nanozyme
exhibits
peroxidase-like
up
2820
U
mg
ACS Nano,
Год журнала:
2022,
Номер
16(3), С. 4536 - 4550
Опубликована: Март 3, 2022
Due
to
the
lack
of
a
general
descriptor
predict
activity
nanomaterials,
current
exploration
nanozymes
mainly
depended
on
trial-and-error
strategies,
which
hindered
effective
design
nanozymes.
Here,
with
help
large
number
Ni–O–Co
bonds
at
interface
heterostructures,
prediction
was
successfully
determined
reveal
double
enzyme-like
mechanisms
for
Ni/CoMoO4.
Additionally,
DFT
calculations
revealed
that
engineering
could
accelerate
catalytic
kinetics
activity.
were
main
active
sites
Finally,
colorimetric
signal
and
intelligent
biosensor
Ni/CoMoO4
based
deep
learning
used
detect
organophosphorus
ziram
sensitively.
Meanwhile,
in
situ
FTIR
results
uncovered
detection
mechanism:
target
molecules
block
heterostructure
leading
peak
decreasing.
This
study
not
only
provided
well
strategy
further
development
or
other
advanced
catalysts,
but
it
also
designed
multifunctional
platform.
Furthermore,
preferable
ideas
regarding
mechanism
ACS Nano,
Год журнала:
2023,
Номер
17(7), С. 6833 - 6848
Опубликована: Март 28, 2023
Specific
generation
of
reactive
oxygen
species
(ROS)
within
tumors
in
situ
catalyzed
by
nanozymes
is
a
promising
strategy
for
cancer
therapeutics.
However,
it
remains
significant
challenge
to
fabricate
highly
efficient
acting
the
tumor
microenvironment.
Herein,
we
develop
bimetallic
nanozyme
(Pt50Sn50)
with
photothermal
enhancement
dual
enzymatic
activities
catalytic
therapy.
The
structures
and
PtSn
nanoclusters
(BNCs)
different
Sn
content
are
explored
evaluated
systematically.
Experimental
comparisons
show
that
Pt50Sn50
BNCs
exhibit
highest
among
all
those
investigated,
including
activity
property,
due
SnO2–x
vacancy
(Ovac)
sites
on
surface
BNCs.
Specifically,
photothermal-enhanced
peroxidase-like
catalase-like
activities,
as
well
significantly
enhanced
anticancer
efficacy
both
multicellular
spheroids
vivo
experiments.
Due
high
X-ray
attenuation
coefficient
excellent
light
absorption
also
dual-mode
imaging
capacity
computed
tomography
photoacoustic
imaging,
which
could
achieve
real-time
monitoring
therapeutic
process.
Therefore,
this
work
will
advance
development
noble-metal
optimal
composition
Colloids and Surfaces B Biointerfaces,
Год журнала:
2022,
Номер
221, С. 112950 - 112950
Опубликована: Окт. 20, 2022
Nanozymes
are
super-efficient
nanomaterials
with
enzyme-like
characteristics,
as
the
name
suggests.
In
last
decade,
efforts
have
been
made
to
develop
"artificial
enzymes,"
which
alternatives
natural
enzymes.
As
nanoscience
and
nanotechnology
advance,
nanozymes,
catalytic
having
properties,
fascinated
researchers'
attention.
unique
physicochemical
properties
that
mimic
activity
gained
a
special
interest
in
industrial
sectors.
However,
several
constraints
hampered
their
effective
deployment
processes,
including
denaturation,
time-consuming
manufacturing,
overall
high
cost-ratio,
reutilization
challenges.
After
brief
overview
of
nanozyme
research,
an
analysis
similarities
differences
between
nanozymes
synthetic
enzymes
is
presented.
Because
distinct
stand
out
this
comparison.
exhibited
variety
applications
leveraging
physiochemical
nanomaterials,
ranging
from
vitro
detection
enzyme
substitution
biological
systems.
addition,
introduced
new
field
called
nanozymology,
blends
enzymology.
