Surface Ligand Engineering Ruthenium Nanozyme Superior to Horseradish Peroxidase for Enhanced Immunoassay

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: April 22, 2023

Nanozymes have great potential to be used as an alternative natural enzymes in a variety of fields. However, low catalytic activity compared with limits their practical use. It is still challenging design nanozymes comparable counterparts terms the specific activity. In this study, surface engineering strategy employed improve Ru using charge-transferrable ligands such polystyrene sulfonate (PSS). PSS-modified nanozyme exhibits peroxidase-like up 2820 U mg

Language: Английский

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Nanozyme-based pollutant sensing and environmental treatment: Trends, challenges, and perspectives

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 854, P. 158771 - 158771

Published: Sept. 13, 2022

Language: Английский

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Rational Construction of a Ni/CoMoO₄ Heterostructure with Strong Ni–O–Co Bonds for Improving Multifunctional Nanozyme Activity

ACS Nano, Journal Year: 2022, Volume and Issue: 16(3), P. 4536 - 4550

Published: March 3, 2022

Due to the lack of a general descriptor predict activity nanomaterials, current exploration nanozymes mainly depended on trial-and-error strategies, which hindered effective design nanozymes. Here, with help large number Ni–O–Co bonds at interface heterostructures, prediction was successfully determined reveal double enzyme-like mechanisms for Ni/CoMoO4. Additionally, DFT calculations revealed that engineering could accelerate catalytic kinetics activity. were main active sites Finally, colorimetric signal and intelligent biosensor Ni/CoMoO4 based deep learning used detect organophosphorus ziram sensitively. Meanwhile, in situ FTIR results uncovered detection mechanism: target molecules block heterostructure leading peak decreasing. This study not only provided well strategy further development or other advanced catalysts, but it also designed multifunctional platform. Furthermore, preferable ideas regarding mechanism

Language: Английский

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Dual Nanozyme-Driven PtSn Bimetallic Nanoclusters for Metal-Enhanced Tumor Photothermal and Catalytic Therapy

ACS Nano, Journal Year: 2023, Volume and Issue: 17(7), P. 6833 - 6848

Published: March 28, 2023

Specific generation of reactive oxygen species (ROS) within tumors in situ catalyzed by nanozymes is a promising strategy for cancer therapeutics. However, it remains significant challenge to fabricate highly efficient acting the tumor microenvironment. Herein, we develop bimetallic nanozyme (Pt50Sn50) with photothermal enhancement dual enzymatic activities catalytic therapy. The structures and PtSn nanoclusters (BNCs) different Sn content are explored evaluated systematically. Experimental comparisons show that Pt50Sn50 BNCs exhibit highest among all those investigated, including activity property, due SnO2–x vacancy (Ovac) sites on surface BNCs. Specifically, photothermal-enhanced peroxidase-like catalase-like activities, as well significantly enhanced anticancer efficacy both multicellular spheroids vivo experiments. Due high X-ray attenuation coefficient excellent light absorption also dual-mode imaging capacity computed tomography photoacoustic imaging, which could achieve real-time monitoring therapeutic process. Therefore, this work will advance development noble-metal optimal composition

Language: Английский

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Piezoelectric enhanced peroxidase-like activity of metal-free sulfur doped graphdiyne nanosheets for efficient water pollutant degradation and bacterial disinfection

Nano Today, Journal Year: 2022, Volume and Issue: 43, P. 101429 - 101429

Published: Feb. 12, 2022

Language: Английский

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