Vaccines,
Год журнала:
2022,
Номер
10(7), С. 1135 - 1135
Опубликована: Июль 16, 2022
Initial
clinical
trials
and
surveillance
data
have
shown
that
the
most
commonly
administered
BNT162b2
COVID-19
mRNA
vaccine
is
effective
safe.
However,
several
cases
of
vaccine-induced
mild
to
moderate
adverse
events
were
recently
reported.
Here,
we
report
a
rare
case
myositis
after
injection
first
dose
into
left
deltoid
muscle
34-year-old,
previously
healthy
woman
who
presented
progressive
proximal
weakness,
dysphagia,
dyspnea
with
respiratory
failure.
One
month
vaccination,
expression
was
detected
in
tissue
biopsy
right
quadriceps
muscles.
We
propose
this
as
example
myositis.
This
study
comprehensively
characterizes
molecular
features
vaccine-associated
which
patient
severely
affected.
Additive manufacturing,
Год журнала:
2023,
Номер
71, С. 103598 - 103598
Опубликована: Май 9, 2023
The
three-dimensional
(3D)
printing
and
its
extension
four-dimensional
(4D)
technique
show
great
promise
for
advanced
additive
manufacturing
of
functional
architected
materials
with
engineered
micro-
nanoscale
features.
actual
usage
to
produce
3D/4D
structures
is
primarily
dependent
on
the
improvement
printable
polymeric
inks.
Thermoresponsive
polymers
(TRPs)
broad
application
prospects
in
since
they
enable
changing
physicochemical
properties
system
at
a
specific
temperature.
Continuing
progress
understanding
TRP
phenomena
design
new
feedstocks
their
compatibility
fabrication
processes.
Therefore,
increasing
overlap
between
fields
fundamental
TRPs
application-based
research
efforts
can
be
important
emerging
technology.
In
this
review,
we
provide
an
overview
TRPs,
different
classes
3D
printing,
ranging
from
biosensors
via
self-assembly
variety
biofabrication,
biomedical,
biotechnology,
food
applications.
Basic
knowledge
imperative
processes
like
gelation
mechanisms
bio-based
adsorption
surfaces
adhesion,
strategies
using
also
provided.
For
diverse
synthesis
basic
physical
chemical
features
are
described
mechanism
behavior
highlighted.
Fabrication
methods
have
been
discussed
describing
several
detail.
Vaccines,
Год журнала:
2024,
Номер
12(2), С. 186 - 186
Опубликована: Фев. 12, 2024
In
recent
years,
lipid
nanoparticles
(LNPs)
have
attracted
extensive
attention
in
tumor
immunotherapy.
Targeting
immune
cells
cancer
therapy
has
become
a
strategy
of
great
research
interest.
mRNA
vaccines
are
potential
choice
for
immunotherapy,
due
to
their
ability
directly
encode
antigen
proteins
and
stimulate
strong
response.
However,
the
mode
delivery
lack
stability
key
issues
limiting
its
application.
LNPs
an
excellent
carrier,
structural
biocompatibility
make
them
effective
means
delivering
specific
targets.
This
study
summarizes
progress
LNP
carrier-assisted
targeted
controlled
release
immunity.
The
role
improving
stability,
immunogenicity,
targeting
is
discussed.
review
aims
systematically
summarize
latest
immunity
provide
new
ideas
strategies
as
well
more
treatment
plans
patients.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(13)
Опубликована: Фев. 4, 2023
Abstract
The
recent
development
of
RNA‐based
therapeutics
in
delivering
nucleic
acids
for
gene
editing
and
regulating
protein
translation
has
led
to
the
effective
treatment
various
diseases
including
cancer,
inflammatory
genetic
disorder,
as
well
infectious
diseases.
Among
these,
lipid
nanoparticles
(LNP)
have
emerged
a
promising
platform
RNA
delivery
shed
light
by
resolving
inherent
instability
issues
naked
thereby
enhancing
therapeutic
potency.
These
LNP
consisting
ionizable
lipid,
helper
cholesterol,
poly(ethylene
glycol)‐anchored
can
stably
enclose
help
them
release
into
cells’
cytosol.
Herein,
significant
progress
made
research
starting
from
constituents,
formulation,
their
diverse
applications
is
summarized
first.
Moreover,
microfluidic
methodologies
which
allow
precise
assembly
these
newly
developed
constituents
achieve
with
controllable
composition
size,
high
encapsulation
efficiency
scalable
production
are
highlighted.
Furthermore,
short
discussion
on
current
challenges
an
outlook
will
be
given
emerging
approaches
issues.
Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
113(7), С. 1726 - 1748
Опубликована: Апрель 4, 2024
The
production
of
paediatric
pharmaceutical
forms
represents
a
unique
challenge
within
the
industry.
primary
goal
these
formulations
is
to
ensure
therapeutic
efficacy,
safety,
and
tolerability
in
patients,
who
have
specific
physiological
needs
characteristics.
In
recent
years,
there
has
been
significant
increase
attention
towards
this
area,
driven
by
need
improve
drug
administration
children
optimal
treatments.
Technological
innovation
played
crucial
role
meeting
requirements,
opening
new
frontiers
design
forms.
particular,
three
emerging
technologies
garnered
considerable
interest
scientific
industrial
community:
3D
printing,
prilling/vibration,
microfluidics.
These
offer
advanced
approaches
for
design,
production,
customization
forms,
allowing
more
precise
dosage
modulation,
improved
solubility,
greater
acceptability.
review,
we
delve
into
cutting-edge
their
impact
on
We
analyse
potential,
associated
challenges,
developments,
providing
comprehensive
overview
opportunities
that
innovative
methodologies
sector.
examine
different
generated
using
techniques,
evaluating
advantages
disadvantages.
Bioengineering,
Год журнала:
2024,
Номер
11(7), С. 664 - 664
Опубликована: Июнь 28, 2024
Recent
advancements
in
3D
bioprinting
and
microfluidic
lab-on-chip
systems
offer
promising
solutions
to
the
limitations
of
traditional
animal
models
biomedical
research.
Three-dimensional
enables
creation
complex,
patient-specific
tissue
that
mimic
human
physiology
more
accurately
than
models.
These
bioprinted
tissues,
when
integrated
with
systems,
can
replicate
dynamic
environment
body,
allowing
for
development
multi-organ
This
integration
facilitates
precise
drug
screening
personalized
therapy
by
simulating
interactions
between
different
organ
systems.
Such
innovations
not
only
improve
predictive
accuracy
but
also
address
ethical
concerns
associated
testing,
aligning
three
Rs
principle.
Future
directions
include
enhancing
resolution,
developing
advanced
bioinks,
incorporating
AI
optimized
system
design.
technologies
hold
potential
revolutionize
development,
regenerative
medicine,
disease
modeling,
leading
effective,
personalized,
humane
treatments.
Advances in Physics X,
Год журнала:
2025,
Номер
10(1)
Опубликована: Янв. 15, 2025
The
COVID-19
pandemic
has
ignited
a
search
for
innovative
solutions
to
tackle
viral
transmission
and
ensure
early
detection.
Graphene
its
derivatives
have
emerged
as
promising
materials
in
this
fight,
showcasing
impressive
potential
across
diverse
range
of
applications.
From
frontline
defenses
like
antiviral
PPE
with
enhanced
filtration
breathability
microscopic
detective
work
via
highly
sensitive
FET
biosensors,
graphene
offers
multifaceted
attack
on
the
SARS-CoV-2
virus.
Its
impact
extends
beyond
diagnostics,
empowering
energy
storage
disinfection
technologies
while
revolutionizing
drug
delivery
air
purification
through
virus-capturing
filters.
Antiviral
coatings
vigilant
nano-sensors
further
bolster
arsenal,
offering
comprehensive
protection
at
surface
levels.
Moreover,
graphene-based
masks,
their
reduce
pollution
exposure,
may
even
offer
an
additional
layer
against
polluted
areas.
In
summary,
emerges
versatile
guardian
COVID-19,
poised
revolutionize
fight
beyond.
applications,
coupled
ongoing
research,
paint
compelling
picture
future
where
one
atom
time,
rewrites
narrative
defense.
