Polish Journal of Microbiology,
Год журнала:
2022,
Номер
71(4), С. 577 - 587
Опубликована: Дек. 1, 2022
This
study
aimed
to
determine
the
genetic
alterations
in
Omicron
variants
compared
other
of
concern
(VOCs)
trace
evolutionary
genetics
SARS-CoV-2
responsible
for
multiple
COVID-19
waves
globally.
The
present
is
an
silico
analysis
determining
evolution
selected
11
VOCs
original
Wuhan
strain.
included
six
Omicrons
and
one
variant
Alpha,
Beta,
Delta,
Gamma,
Mu.
pairwise
alignment
with
local
search
tool
NCBI
Nucleotide-BLAST
Protein-BLAST
were
used
nucleotide
base
changes
corresponding
amino
acid
proteins,
respectively.
genomic
revealed
210
changes;
most
these
(127/210,
60.5%)
non-synonymous
mutations
that
occurred
mainly
S
gene
(52/127,
40.1%).
remaining
10.5%
(22/210)
1.9%
(4/210)
frameshift
deletions
insertions,
insertion
(Ins22194T
T22195G)
led
deletion
(Δ211N).
Only
four
(C241T,
C3037T,
C14408T,
A23403G)
shared
among
all
VOCs.
resulted
61
changes,
while
showed
changes.
(38/61,
62.3%)
gene;
34.2%
them
(13/38)
receptor-binding
domain.
confirmed
developed
by
vaccine
target
(S
gene).
Materials Today Advances,
Год журнала:
2022,
Номер
16, С. 100314 - 100314
Опубликована: Ноя. 2, 2022
Manufacturing
of
metal
and
oxide
nanoparticles
(M/MO
NPs)
in
large
quantities
needed
a
strong
reliable,
sustainable,
eco-friendly
protocol.
Present
work
represents
on
biogenic
approaches
to
fabricate
green
using
technology.
The
fabrications
M/MO
NPs
natural
bio-resources
were
engaged
by
means
alternative
technique
place
conventional
methods.
These
methods
are
naturally
benign,
straightforward,
economical,
renewed
technology;
they
does
not
content
harmful
chemicals,
zero
contaminants,
eco-friendly.
extracts
from
the
resources
widely
accepted
owing
its
capability
minimise
control
size
shape
oxides
because
different
structure
directing
agents,
usually
bioorganic
phyto-chemicals.
In
this
present
review,
we
have
summarized
fabrication
like
silver,
gold,
copper
oxide,
cobalt
titanium
cerium
bismuth
zinc
nickel
resources.
challenges,
limiting
factors
future
directions
bioinspired
synthesis
metal/metal
also
highlighted
review.
Moreover,
materials
has
explored
for
further
environmental
remediation
terms
photocatalytic
activity,
elimination
organic
waste,
antibacterial,
antioxidant
assay,
protein-metal
complexes
binding
affinities
molecular
docking.
Journal of drug targeting,
Год журнала:
2024,
Номер
32(7), С. 794 - 806
Опубликована: Май 14, 2024
Nanoparticles
(NPs)
have
played
a
pivotal
role
in
various
biomedical
applications,
spanning
from
sensing
to
drug
delivery,
imaging
and
anti-viral
therapy.
The
therapeutic
utilisation
of
NPs
clinical
trials
was
established
the
early
1990s.
Silver
nanoparticles
(AgNPs)
possess
anti-microbial,
anti-cancer
properties,
which
make
them
possible
combat
COVID-19
virus.
Free
radicals
reactive
oxygen
species
are
produced
by
AgNPs,
causes
apoptosis
induction
prevents
viral
contamination.
shape
size
AgNPs
can
influence
their
interactions
biological
activities.
Therefore,
it
is
recommended
that
silver
be
used
as
valuable
tool
management
pandemic.
These
strong
anti-microbial
allowing
penetrate
destroy
microbial
cells.
Additionally,
toxicity
level
depends
on
administered
dose,
surface
modifications
necessary
reduce
toxicity,
preventing
direct
interaction
between
metal
surfaces
By
utilising
nanoparticles,
drugs
targeted
specific
areas
body.
For
example,
case
COVID-19,
stimulated
lungs
accelerate
disease
recovery.
Nanoparticle-based
systems
capability
transport
treat
body
parts.
This
review
offers
an
examination
nanoparticle-based
delivery
for
combatting
with
objective
boosting
bioavailability
existing
medications,
decreasing
raising
efficiency.
Molecules,
Год журнала:
2023,
Номер
28(6), С. 2735 - 2735
Опубликована: Март 17, 2023
The
COVID-19
pandemic
caused
by
SARS-CoV-2
has
majorly
impacted
public
health
and
economies
worldwide.
Although
several
effective
vaccines
drugs
are
now
used
to
prevent
treat
COVID-19,
natural
products,
especially
flavonoids,
showed
great
therapeutic
potential
early
in
the
thus
attracted
particular
attention.
Quercetin,
baicalein,
baicalin,
EGCG
(epigallocatechin
gallate),
luteolin
among
most
studied
flavonoids
this
field.
Flavonoids
can
directly
or
indirectly
exert
antiviral
activities,
such
as
inhibition
of
virus
invasion
replication
viral
proteases.
In
addition,
modulate
levels
interferon
proinflammatory
factors.
We
have
reviewed
previously
reported
relevant
literature
researching
pharmacological
anti-SARS-CoV-2
activity
where
structures,
classifications,
synthetic
pathways,
effects
summarized.
There
is
no
doubt
that
treatment
COVID-19.
However,
current
research
still
theoretical
stage.
More
studies
recommended
evaluate
efficacy
safety
against
SARS-CoV-2.
Molecules,
Год журнала:
2023,
Номер
28(10), С. 4169 - 4169
Опубликована: Май 18, 2023
Asymmetric-flow
field-flow
fractionation
(AF4)
is
a
gentle,
flexible,
and
powerful
separation
technique
that
widely
utilized
for
fractionating
nanometer-sized
analytes,
which
extend
to
many
emerging
nanocarriers
drug
delivery,
including
lipid-,
virus-,
polymer-based
nanoparticles.
To
ascertain
quality
attributes
suitability
of
these
nanostructures
as
delivery
systems,
particle
size
distributions,
shape,
morphology,
composition,
stability,
it
imperative
comprehensive
analytical
tools
be
used
characterize
the
native
properties
The
capacity
AF4
readily
coupled
multiple
online
detectors
(MD-AF4)
or
non-destructively
fractionated
analyzed
offline
make
this
broadly
compatible
with
multitude
characterization
strategies,
can
provide
insight
on
size,
mass,
dispersity,
other
critical
attributes.
This
review
will
critically
investigate
MD-AF4
reports
characterizing
nanoparticles
in
especially
those
reported
last
10–15
years
simultaneously
downstream
from
fractionation.
Phytotherapy Research,
Год журнала:
2024,
Номер
38(3), С. 1589 - 1609
Опубликована: Янв. 29, 2024
Abstract
The
severe
acute
respiratory
syndrome
coronavirus
2
(SARS‐CoV‐2)
causes
COVID‐19
disease.
Through
its
viral
spike
(S)
protein,
the
virus
enters
and
infects
epithelial
cells
by
utilizing
angiotensin‐converting
enzyme
as
a
host
cell's
receptor
protein.
pandemic
had
profound
impact
on
global
public
health
economies.
Although
various
effective
vaccinations
medications
are
now
available
to
prevent
treat
COVID‐19,
natural
compounds
derived
from
medicinal
plants,
particularly
flavonoids,
demonstrated
therapeutic
potential
Flavonoids
exhibit
dual
antiviral
mechanisms:
direct
interference
with
invasion
inhibition
of
replication.
Specifically,
they
target
key
molecules,
proteases,
involved
in
infection.
These
showcase
significant
immunomodulatory
anti‐inflammatory
properties,
effectively
inhibiting
inflammatory
cytokines.
Additionally,
emerging
evidence
supports
flavonoids
mitigate
progression
individuals
obesity
positively
influencing
lipid
metabolism.
This
review
aims
elucidate
molecular
structure
SARS‐CoV‐2
underlying
mechanism
action
virus.
study
evaluates
anti‐SARS‐CoV‐2
properties
exhibited
flavonoid
compounds,
specific
interest
their
mechanisms
action,
applications
for
prevention
treatment
COVID‐19.
Nevertheless,
portion
existing
knowledge
is
based
theoretical
frameworks
findings
vitro
investigations.
Further
research
required
better
assess
effectiveness
combating
SARS‐CoV‐2,
particular
emphasis
vivo
clinical
Advances in chemical and materials engineering book series,
Год журнала:
2024,
Номер
unknown, С. 1 - 35
Опубликована: Фев. 8, 2024
Observing
the
unique
properties
of
matter
at
nanoscale,
nanoscience
provides
innovative
solutions
for
energy,
environment,
agriculture,
and
manufacturing,
addresses
critical
challenges
sustainability.
This
chapter
highlights
nanotechnology's
pivotal
role
in
advancing
sustainability
across
diverse
domains
including
medicine,
consumer
products,
energy
optimization.
Ethical
considerations,
potential
benefits,
future
prospects
are
thoroughly
examined,
providing
a
comprehensive
overview
transformative
capacity.
The
rational
design
nanomaterials
achieves
exceptionally
high
surface
areas,
offering
strategic
enhancements.
In
era
electronics,
nanotechnology
accelerates
devices,
enhances
memory
chip
density,
reduces
power
consumption,
shaping
more
sustainable
technological
future.
serves
as
valuable
reference
research
community,
insights
into
applications
development
circular
economy,
aims
to
deepen
understanding
exploration
drive
positive
change.
Tissue
repair
and
regeneration
are
critical
processes
for
maintaining
the
integrity
function
of
various
organs
tissues.
Recently,
polysaccharide
materials
protein
have
garnered
interest
use
in
tissue
strategies.
However,
polysaccharides
more
stable
unaffected
by
temperature
pH
changes
compared
to
proteins,
some
can
provide
stronger
mechanical
support,
which
is
particularly
important
constructing
tissue-engineered
scaffolds
wound
dressings.
This
Review
provides
an
in-depth
overview
origins
polysaccharides,
advantages
materials,
processing
design
In
addition,
potential
restoration
tissues
such
as
skin,
heart,
nerves
highlighted.
Finally,
we
discuss
depth
challenges
that
still
face
repair,
stability
material,
regulating
characteristics
deterioration
rates
under
different
conditions.
To
achieve
effective
regeneration,
future
research
must
focus
on
further
improving
functionalities
materials.
