Aggregation‐enhanced photothermal therapy of organic dyes DOI

Mengyun Yang,

Chendong Ji, Meizhen Yin

и другие.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2024, Номер 16(3)

Опубликована: Май 1, 2024

Abstract Photothermal therapy (PTT) represents a groundbreaking approach to targeted disease treatment by harnessing the conversion of light into heat. The efficacy PTT heavily relies on capabilities photothermal agents (PTAs). Among PTAs, those based organic dyes exhibit notable characteristics such as adjustable absorption wavelengths, high extinction coefficients, and compatibility in biological systems. However, challenge associated with dye‐based PTAs lies their efficiency converting heat while maintaining stability. Manipulating dye aggregation is key aspect modulating non‐radiative decay pathways, aiming augment generation. This review delves various strategies aimed at improving performance through constructing aggregation. These including protecting from photodegradation, inhibiting non‐photothermal space within molecular aggregates, introducing intermolecular photophysical processes. Overall, this highlights precision‐driven assembly promising frontier enhancing PTT‐related applications. article categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies Nanomedicine for Oncologic Disease Diagnostic Tools In Vivo Nanodiagnostics Imaging

Язык: Английский

An Enzyme‐Engineered Nonporous Copper(I) Coordination Polymer Nanoplatform for Cuproptosis‐Based Synergistic Cancer Therapy DOI
Yuzhi Xu, Si‐Yang Liu, Leli Zeng

и другие.

Advanced Materials, Год журнала: 2022, Номер 34(43)

Опубликована: Сен. 2, 2022

Abstract Cuproptosis, a newly identified form of regulated cell death that is copper‐dependent, offers great opportunities for exploring the use copper‐based nanomaterials inducing cuproptosis cancer treatment. Here, glucose oxidase (GOx)‐engineered nonporous copper(I) 1,2,4‐triazolate ([Cu(tz)]) coordination polymer (CP) nanoplatform, denoted as GOx@[Cu(tz)], starvation‐augmented and photodynamic synergistic therapy developed. Importantly, catalytic activity GOx shielded in scaffold but can be “turned on” efficient depletion only upon glutathione (GSH) stimulation cells, thereby proceeding starvation therapy. The GSH sensitizes cells to GOx@[Cu(tz)]‐mediated cuproptosis, producing aggregation lipoylated mitochondrial proteins, target copper‐induced toxicity. increased intracellular hydrogen peroxide (H 2 O ) levels, due oxidation glucose, activates type I (PDT) efficacy GOx@[Cu(tz)]. vivo experimental results indicate GOx@[Cu(tz)] produces negligible systemic toxicity inhibits tumor growth by 92.4% athymic mice bearing 5637 bladder tumors. This thought first report cupreous nanomaterial capable cuproptosis‐based cancer, which should invigorate studies pursuing rational design efficacious strategies based on cuproptosis.

Язык: Английский

Процитировано

275
A Noble AuPtAg‐GOx Nanozyme for Synergistic Tumor Immunotherapy Induced by Starvation Therapy‐Augmented Mild Photothermal Therapy DOI Creative Commons
Man Wang, Mengyu Chang, Pan Zheng

и другие.

Advanced Science, Год журнала: 2022, Номер 9(31)

Опубликована: Сен. 25, 2022

Abstract Notwithstanding immune checkpoint blocking (ICB) therapy has made eminent clinical breakthroughs, overcoming immunologically “cold” tumors remains challenging. Here, a cascade potentiated nanomodulator AuPtAg‐GOx is engineered for boosting responsiveness. Upon 1064 nm laser irradiation, AuPtAg‐mediated mild photothermal (PTT) activates cytotoxic T lymphocytes and reverses the immunogenic tumor microenvironment. Further, to amplify thermal sensitivity of cells, glucose oxidase (GOx) introduced suppress production heat shock proteins, thereby promoting therapy. Complementarily, AuPtAg nanozymes with catalase‐like activity can ameliorate hypoxia, significantly improving GOx activity. As result, combination self‐augmented ability PD‐L1 antibody further escalate antitumor efficacy. The AuPtAg‐GOx‐based synergistic starvation therapy, PTT, immunotherapy enhancement strategy be favorable tool effectively kill cancer cells.

Язык: Английский

Процитировано

112
Recent advances in near-infrared-II hollow nanoplatforms for photothermal-based cancer treatment DOI Creative Commons
Li Zhang, Gerile Oudeng,

Feiqiu Wen

и другие.

Biomaterials Research, Год журнала: 2022, Номер 26(1)

Опубликована: Сен. 30, 2022

Near-infrared-II (NIR-II, 1000-1700 nm) light-triggered photothermal therapy (PTT) has been regarded as a promising candidate for cancer treatment, but PTT alone often fails to achieve satisfactory curative outcomes. Hollow nanoplatforms prove be attractive in the biomedical field owing merits including good biocompatibility, intrinsic physical-chemical nature and unique hollow structures, etc. On one hand, themselves can NIR-II agents (PTAs), cavities of which are able carry diverse therapeutic units realize multi-modal therapies. other PTAs capable decorating on surface combine with functions components encapsulated inside synergistic treatment. Notably, generally serve photoacoustic imaging (PAI) contrast (CAs), means such kind also expected multifunctional all-in-one nanotheranostics. In this review, recent advances single-modal PTT, dual-modal PTT/photodynamic (PDT), PTT/chemotherapy, PTT/catalytic PTT/gas well PTT/chemodynamic (CDT)/chemotherapy, PTT/chemo/gene PTT/PDT/CDT/starvation (ST)/immunotherapy summarized first time. Before these, typical synthetic strategies structures presented, lastly, potential challenges perspectives related these novel paradigms future research clinical translation discussed.

Язык: Английский

Процитировано

79
Dual-Responsive Triple-Synergistic Fe-MOF for Tumor Theranostics DOI
Zhiwei Chen,

Yaoji Sun,

Jiawei Wang

и другие.

ACS Nano, Год журнала: 2023, Номер 17(10), С. 9003 - 9013

Опубликована: Апрель 28, 2023

The intelligent responsive drug delivery system has great application potential in cancer precision therapy. Although many antitumor methods have been developed based on systems, most of them yet suffer from poor efficiency. In this project, a near-infrared and pH dual-response multimodal collaborative platform for diagnosis treatment (PCN-DOX@PDA) was constructed. We used PCN-600 as vehicle loaded with antineoplastic drugs polydopamine (PDA). Under 633 nm laser irradiation, the ligand tetrakis(4-carboxyphenyl)porphyrin (TCPP) can generate singlet oxygen (1O2) kill tumor cells. PDA is photothermal agent PTT. PCN-DOX@PDA achieves release by responding to weak acidity microenvironment thermal stimulation generated NIR irradiation. addition, since central ion PCN Fe3+, realizes tumors through magnetic resonance imaging-mediated chemotherapy photodynamic synergistic This triple strategy showed excellent biocompatibility ability vivo experiments 4T1 tumor-bearing mouse model, indicating that good development prospect field therapy diversified biomedical applications.

Язык: Английский

Процитировано

62
Recent advances and prospects in organic molecule-based phototheranostic agents for enhanced cancer phototherapy DOI
Yuanyuan Zhao, Heejeong Kim, Nguyễn Văn Nghĩa

и другие.

Coordination Chemistry Reviews, Год журнала: 2023, Номер 501, С. 215560 - 215560

Опубликована: Ноя. 27, 2023

Язык: Английский

Процитировано

54
A Multichannel Metabolic Pathway Interference Strategy for Complete Energy Depletion‐Mediated Cancer Therapy DOI
He Ding,

Jianye Wei,

Linyang Fang

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер 34(19)

Опубликована: Янв. 18, 2024

Abstract Hydrogen sulfide (H 2 S) is being progressively integrated as an emerging inhibitor of the electron transport chain in energy interference‐based tumor therapy. However, metabolic reprogramming cancer cells causes both oxidative phosphorylation (OXPHOS) and glycolysis to occur simultaneously, which contributes ineffective therapeutic effect blocking a single pathway. To achieve complete suppression production, inorganic H S donor ZnS@ZIF‐8@CaP nanoparticle (ZSZC NP) carrying Ca Zn constructed for achieving simultaneous interference OXPHOS glycolysis. The core–shell ZSZC nanoparticles can break down microenvironment. This leads sustained release calcium overload disrupt normal functioning mitochondria by inhibiting expression cytochrome c causing damage mitochondrial membrane potential. Meanwhile, presence 2+ hinders typical process impeding lactate dehydrogenase glyceraldehyde‐3‐phosphate dehydrogenase. synchronous hampers supply cells. Additionally, expedite necrosis vivo inducing cellular acidification calcification. Therefore, this energy‐blocking strategy will completely deplete reserves provide new insights exploring bioenergetic inhibition treatment approach.

Язык: Английский

Процитировано

30
Recent advances in the design of organic photothermal agents for cancer treatment: A review DOI

Seongman Lee,

Suhong Min,

Gahyun Kim

и другие.

Coordination Chemistry Reviews, Год журнала: 2024, Номер 506, С. 215719 - 215719

Опубликована: Фев. 24, 2024

Язык: Английский

Процитировано

20
Recent Advances in Strategies to Enhance Photodynamic and Photothermal Therapy Performance of Single‐Component Organic Phototherapeutic Agents DOI Creative Commons
Laiping Fang,

Zengzhen Chen,

Jianan Dai

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Abstract Photodynamic therapy (PDT) and photothermal (PTT) have emerged as promising treatment options, showcasing immense potential in addressing both oncologic nononcologic diseases. Single‐component organic phototherapeutic agents (SCOPAs) offer advantages compared to inorganic or multicomponent nanomedicine, including better biosafety, lower toxicity, simpler synthesis, enhanced reproducibility. Nonetheless, how further improve the therapeutic effectiveness of SCOPAs remains a challenging research area. This review delves deeply into strategies performance PDT PTT by optimizing structural design SCOPAs. These encompass augmenting reactive oxygen species (ROS) generation, mitigating dependence, elevating light absorption capacity, broadening region, enhancing conversion efficiency (PCE). Additionally, this also underscores ideal for developing with balanced PTT. Furthermore, synergies are highlighted between other modalities such ferroptosis, gas therapy, chemotherapy, immunotherapy. By providing comprehensive analysis these strategies, aspires serve valuable resource clinicians researchers, facilitating wider application advancement SCOPAs‐mediated

Язык: Английский

Процитировано

3
Photoactivatable Immunostimulatory Nanomedicine for Immunometabolic Cancer Therapy DOI

Wencheng Wu,

Yinying Pu,

Bangguo Zhou

и другие.

Journal of the American Chemical Society, Год журнала: 2022, Номер 144(41), С. 19038 - 19050

Опубликована: Окт. 10, 2022

A rationally designed immunostimulant (CC@SiO2-PLG) with a photoactivatable immunotherapeutic function for synergetic tumor therapy is reported. This CC@SiO2-PLG nanoplatform comprises catalase and photosensitizer (Ce6) co-encapsulated in silica capsule, to which an conjugated through reactive oxygen species-cleavable linker. After accumulating tissue, generates O2 relieve hypoxia promotes the production of singlet (1O2) upon laser irradiation, resulting not only destruction but also release tumor-associated antigens (TAAs). Simultaneously, linker breakage by photoproduced 1O2 leads remote-controlled indoleamine 2,3-dioxygenase (IDO) inhibitor from consequent immunosuppressive microenvironment reversion. The released TAAs conjunction inhibition IDO-mediated tryptophan/kynurenine metabolic pathway induced boosted antitumor immune response CC@SiO2-PLG-mediated phototherapy. Therefore, growth primary/distant tumors lung metastases mouse xenograft model was greatly inhibited, achievable phototherapy alone.

Язык: Английский

Процитировано

47
Activatable Immunoprotease Nanorestimulator for Second Near-Infrared Photothermal Immunotherapy of Cancer DOI

Mengke Xu,

Chi Zhang, Shasha He

и другие.

ACS Nano, Год журнала: 2023, Номер 17(9), С. 8183 - 8194

Опубликована: Май 1, 2023

Photothermal immunotherapy is a combinational cancer therapy modality, wherein the photothermal process can noninvasively ablate and efficiently trigger immunogenic cell death to ignite antitumor immunity. However, cells resist cytotoxic lymphocyte-mediated effect via expressing serine protease inhibitory proteins (serpins) deactivate proteolytic immunoproteases. Herein, we report smart polymer nanoagonist (SPND) with second near-infrared (NIR-II) phototherapeutic ablation tumor-specific immunoprotease granzyme B (GrB) restimulation for immunotherapy. SPND has semiconducting backbone grafted small-molecule inhibitor of serpinB9 (Sb9i) glutathione (GSH)-cleavable linker. Once in tumor, Sb9i be specifically liberated from inhibit serpinB9, restimulating activity GrB enhance Moreover, induces direct tumor (ICD) under NIR-II photoirradiation. Therefore, such represents way toward combination (PTI).

Язык: Английский

Процитировано

35