Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(3)
Опубликована: Май 1, 2024
Abstract
Photothermal
therapy
(PTT)
represents
a
groundbreaking
approach
to
targeted
disease
treatment
by
harnessing
the
conversion
of
light
into
heat.
The
efficacy
PTT
heavily
relies
on
capabilities
photothermal
agents
(PTAs).
Among
PTAs,
those
based
organic
dyes
exhibit
notable
characteristics
such
as
adjustable
absorption
wavelengths,
high
extinction
coefficients,
and
compatibility
in
biological
systems.
However,
challenge
associated
with
dye‐based
PTAs
lies
their
efficiency
converting
heat
while
maintaining
stability.
Manipulating
dye
aggregation
is
key
aspect
modulating
non‐radiative
decay
pathways,
aiming
augment
generation.
This
review
delves
various
strategies
aimed
at
improving
performance
through
constructing
aggregation.
These
including
protecting
from
photodegradation,
inhibiting
non‐photothermal
space
within
molecular
aggregates,
introducing
intermolecular
photophysical
processes.
Overall,
this
highlights
precision‐driven
assembly
promising
frontier
enhancing
PTT‐related
applications.
article
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Emerging
Technologies
Nanomedicine
for
Oncologic
Disease
Diagnostic
Tools
In
Vivo
Nanodiagnostics
Imaging
Materials Today Bio,
Год журнала:
2023,
Номер
23, С. 100834 - 100834
Опубликована: Окт. 20, 2023
Achieving
precision
treatment
in
bone
tissue
engineering
(BTE)
remains
a
challenge.
Photothermal
therapy
(PTT),
as
form
of
therapy,
has
been
extensively
investigated
for
its
safety
and
efficacy.
It
demonstrated
significant
potential
the
orthopedic
diseases
such
tumors,
postoperative
infections
osteoarthritis.
However,
high
temperatures
associated
with
PTT
can
lead
to
certain
limitations
drawbacks.
In
recent
years,
researchers
have
explored
use
biomaterials
mild
photothermal
(MPT),
which
offers
promising
approach
addressing
these
limitations.
This
review
provides
comprehensive
overview
mechanisms
underlying
MPT
presents
compilation
agents
their
utilization
strategies
repair.
Additionally,
paper
discusses
future
prospects
MPT-assisted
regeneration,
aiming
provide
insights
recommendations
optimizing
material
design
this
field.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(3)
Опубликована: Май 1, 2024
Abstract
Photothermal
therapy
(PTT)
represents
a
groundbreaking
approach
to
targeted
disease
treatment
by
harnessing
the
conversion
of
light
into
heat.
The
efficacy
PTT
heavily
relies
on
capabilities
photothermal
agents
(PTAs).
Among
PTAs,
those
based
organic
dyes
exhibit
notable
characteristics
such
as
adjustable
absorption
wavelengths,
high
extinction
coefficients,
and
compatibility
in
biological
systems.
However,
challenge
associated
with
dye‐based
PTAs
lies
their
efficiency
converting
heat
while
maintaining
stability.
Manipulating
dye
aggregation
is
key
aspect
modulating
non‐radiative
decay
pathways,
aiming
augment
generation.
This
review
delves
various
strategies
aimed
at
improving
performance
through
constructing
aggregation.
These
including
protecting
from
photodegradation,
inhibiting
non‐photothermal
space
within
molecular
aggregates,
introducing
intermolecular
photophysical
processes.
Overall,
this
highlights
precision‐driven
assembly
promising
frontier
enhancing
PTT‐related
applications.
article
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Emerging
Technologies
Nanomedicine
for
Oncologic
Disease
Diagnostic
Tools
In
Vivo
Nanodiagnostics
Imaging
